2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcome
2021
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Li J, Moore E, Cambronero F, Pechman K, Liu D, Gifford K, Landman B, Donahue M, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 642-655. PMID: 34743630, PMCID: PMC9051148, DOI: 10.1177/0271678x211056393.Peer-Reviewed Original ResearchConceptsEpisodic memory performanceCognitive performancePathogenesis of Alzheimer's diseaseMemory performanceAlzheimer's disease-related neurodegenerationPoorer cognitive performanceE4 carriersLateral ventricle volumeExecutive functionEpisodic memoryOxygen homeostasisDisease-related neurodegenerationAlzheimer's diseaseBrain agingCognitive impairmentNeuroimaging variablesE4 statusCerebral metabolic rateVentricle volumeOlder adultsBad languageHippocampalNeurodegenerationMetabolic rateMetabolismAssociation of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore E, Liu D, Li J, Schimmel S, Cambronero F, Terry J, Nair S, Pechman K, Moore M, Bell S, Beckman J, Gifford K, Hohman T, Blennow K, Zetterberg H, Carr J, Jefferson A. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology 2021, 97: e329-e340. PMID: 34031194, PMCID: PMC8362359, DOI: 10.1212/wnl.0000000000012257.Peer-Reviewed Original ResearchConceptsPulse wave velocitySynaptic dysfunctionYears of ageP-tauParticipants free of strokeMemory and Aging ProjectFramingham Stroke Risk ProfileFree of strokeT-tauAortic pulse wave velocityCommunity-based studyObservational community-based studyAssociation of aortic stiffnessStroke Risk ProfileAging ProjectOlder adultsTau phosphorylationE4 statusAlzheimer's disease pathologyHypertension statusCentral arterial stiffeningHigher aortic pulse wave velocityYKL-40Risk profileCognitive diagnosis