2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2001
Ultrasound markers of fetal Down syndrome.
Bahado-Singh R, Mendilcioglu I, Copel J. Ultrasound markers of fetal Down syndrome. JAMA 2001, 285: 2857-8. PMID: 11401604.Commentaries, Editorials and LettersRatio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal population
2000
Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation
Bahado‐Singh R, Oz A, Gomez K, Hunter D, Copel J, Baumgarten A, Mahoney M. Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation. Ultrasound In Obstetrics And Gynecology 2000, 15: 199-204. PMID: 10846774, DOI: 10.1046/j.1469-0705.2000.00071.x.Peer-Reviewed Original ResearchConceptsMaternal ageAlpha-fetoproteinTriple screenSerum markersUltrasound biometryDown syndromeNuchal thickness measurementMedian maternal ageSerum alpha-fetoproteinNormal singleton pregnanciesHumerus lengthGestational age rangeDown's syndrome screening efficiencySingleton pregnanciesReferral populationFalse positive rateSecond trimesterIndividual Down syndrome oddsFetal biometryUnconjugated estriolStudy groupNuchal thicknessDown syndrome risk estimationHCGAge range
1999
Prenatal Screening for Down's Syndrome — A Search for the Family's Values
Copel J, Bahado-Singh R. Prenatal Screening for Down's Syndrome — A Search for the Family's Values. New England Journal Of Medicine 1999, 341: 521-522. PMID: 10441609, DOI: 10.1056/nejm199908123410709.Commentaries, Editorials and LettersGestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk
Bahado‐Singh R, Oz U, Kovanci E, Deren O, Feather M, Hsu C, Copel J, Mahoney M. Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk. The Journal Of Maternal-Fetal Medicine 1999, 8: 37-43. PMID: 10090488, DOI: 10.1002/(sici)1520-6661(199903/04)8:2<37::aid-mfm1>3.0.co;2-p.Peer-Reviewed Original ResearchA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriolAn alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickeningNew triple screen test for Down syndrome: Combined urine analytes and serum AFP
Bahado‐Singh R, Oz U, Kovanci E, Cermik D, Flores D, Copel J, Mahoney M, Cole L. New triple screen test for Down syndrome: Combined urine analytes and serum AFP. The Journal Of Maternal-Fetal Medicine 1998, 7: 111-114. PMID: 9642606, DOI: 10.1002/(sici)1520-6661(199805/06)7:3<111::aid-mfm2>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsSerum AFPIndividual Down syndrome oddsMaternal ageTriple screenUrine beta-core fragmentDown syndromeTriple testTriple screen testBeta-core fragmentDown syndrome casesNeural tube defectsDown's syndrome likelihood ratiosEstriol levelsLarge trialsSecond trimesterUrine testsPositive rateEstriol ratioSyndrome casesTube defectsScreen testFalse positive rateAFP dataUrine analytesAFPSubtle ultrasonographic anomalies: Do they improve the Down syndrome detection rate?
Deren O, Mahoney M, Copel J, Bahado-Singh R. Subtle ultrasonographic anomalies: Do they improve the Down syndrome detection rate? American Journal Of Obstetrics And Gynecology 1998, 178: 441-445. PMID: 9539505, DOI: 10.1016/s0002-9378(98)70417-x.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnthropometryCerebral VentriclesDown SyndromeFemaleFingersHumansIntestinesKidney PelvisPredictive Value of TestsPregnancyPregnancy Trimester, SecondProspective StudiesStatistics as TopicUltrasonography, Doppler, ColorUltrasonography, Doppler, TranscranialUltrasonography, Prenatal
1997
Prenatal sonographic findings in 187 fetuses with Down syndrome
Rotmensch S, Liberati M, Bronshtein M, Schoenfeld‐Dimaio M, Shalev J, Ben‐Rafael Z, Copel J. Prenatal sonographic findings in 187 fetuses with Down syndrome. Prenatal Diagnosis 1997, 17: 1001-1009. PMID: 9399347, DOI: 10.1002/(sici)1097-0223(199711)17:11<1001::aid-pd186>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAbnormalities, MultipleDown SyndromeFemaleGestational AgeHumansUltrasonography, PrenatalVaginaConceptsDown syndrome fetusesSonographic findingsSyndrome fetusesFetal karyotypeDown syndromeNuchal fold thicknessAbnormal sonographic findingsInternal organ abnormalitiesPrenatal sonographic findingsDown syndrome detectionEchogenic bowelWeeks' gestationUltrasound scanSame fetusCystic hygromaCardiac defectsConcurrent malformationsFold thicknessStructural abnormalitiesOrgan abnormalitiesFetusesSyndromeAbnormalitiesSyndrome detectionGestationFirst-trimester growth restriction and fetal aneuploidy: The effect of type of aneuploidy and gestational age
Bahado-Singh R, Lynch L, Deren O, Morroti R, Copel J, Mahoney M, Williams J. First-trimester growth restriction and fetal aneuploidy: The effect of type of aneuploidy and gestational age. American Journal Of Obstetrics And Gynecology 1997, 176: 976-980. PMID: 9166154, DOI: 10.1016/s0002-9378(97)70388-0.Peer-Reviewed Original ResearchConceptsCrown-rump lengthGestational ageTrisomy 18First trimester fetal growthFirst-trimester crown-rump lengthLength shorteningFirst-trimester growth restrictionLast menstrual periodReceiver operator characteristic curveFirst-trimester fetusesPrenatal diagnosis centerWeeks' gestationRisk pregnanciesFetal growthAneuploidy riskControl fetusesGrowth restrictionMenstrual periodNormal groupNormal fetusesTrimester fetusesAneuploid fetusesTrisomy 21Trisomy 13Down syndromeFetal transcerebellar diameter in Down syndrome.
Rotmensch S, Goldstein I, Liberati M, Shalev J, Ben-Rafael Z, Copel J. Fetal transcerebellar diameter in Down syndrome. Obstetrics And Gynecology 1997, 89: 534-7. PMID: 9083308, DOI: 10.1016/s0029-7844(97)00076-8.Peer-Reviewed Original Research
1996
Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age
Bahado-Singh R, Deren Ö, Tan A, D'Ancona R, Hunter D, Copel J, Mahoney M. Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age. American Journal Of Obstetrics And Gynecology 1996, 175: 1563-1568. PMID: 8987942, DOI: 10.1016/s0002-9378(96)70107-2.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageMaternal ageDown syndromeNormal ultrasonographyUltrasonography resultsAbdominal circumferenceNuchal thicknessAnatomic defectsChromosomal defectsSmaller abdominal circumferenceChoroid plexus cystsFetal Down syndromeReceiver operator characteristic curveStepwise logistic regressionAbnormal ultrasonography resultsBasis of ageDown syndrome detectionUltrasonographic resultsNormal groupChromosome defectsBiparietal diameterRisk tablesTrisomy 21SyndromeShort humerusRisk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results
Bahado-Singh R, Tan A, Deren O, Hunter D, Copel J, Mahoney M. Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results. American Journal Of Obstetrics And Gynecology 1996, 175: 824-829. PMID: 8885729, DOI: 10.1016/s0002-9378(96)80006-8.Peer-Reviewed Original ResearchNicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening
Rotmensch S, Liberati M, Kardana A, Copel J, Ben-Rafael Z, Cole L. Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening. American Journal Of Obstetrics And Gynecology 1996, 174: 609-611. PMID: 8623792, DOI: 10.1016/s0002-9378(96)70435-0.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinDown syndrome screeningChorionic gonadotropinSyndrome pregnanciesSyndrome screeningFree beta subunitMaternal serum levelsDown syndrome pregnanciesPotential new markerFree β-subunitSerum levelsNormal controlsSensitive markerImmunoenzymometric assaySerum specimensDown syndromeGonadotropinMean levelsNew markersPreliminary dataMedianPregnancyCase levelMarkersΒ-subunit
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesFifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome
Goldstein I, Gomez K, Copel J. Fifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome. Ultrasound In Obstetrics And Gynecology 1995, 5: 34-37. PMID: 7850587, DOI: 10.1046/j.1469-0705.1995.05010034.x.Peer-Reviewed Original ResearchConceptsGestational ageFifth fingerBiparietal diameterDown syndromeFemoral lengthHumeral lengthRoutine biometric measurementsNormal pregnancyWeeks' gestationStudy groupSonographic signsNormal fetusesSyndromePrenatal detectionFurther studiesGestationAgeNormative dataFetusesBiometric measurementsFingerLinear growthDigit measurementsPregnancy
1992
Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination
Bahado-Singh R, Wyse L, Dorr M, Copel J, O'Connor T, Hobbins J. Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination. American Journal Of Obstetrics And Gynecology 1992, 167: 1009-1014. PMID: 1415385, DOI: 10.1016/s0002-9378(12)80029-9.Peer-Reviewed Original ResearchConceptsDown syndrome fetusesSyndrome fetusesFrontothalamic distanceDown syndromePositive predictive valueWeeks' gestationGestational ageNormal medianPosterior thalamusUltrasonographic examinationGroup 52Normal fetusesFrontal lobePredictive valueInner tableFetusesFrontal boneMedianGestationMean valueSyndrome