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John Pawelek, PhD

Senior Research Scientist(ret)in Dermatology

Biography

John Pawelek, PhD was a long-time member of the research faculty in the Department of Dermatology, Yale School of Medicine. His research interests focused on leucocyte-cancer cell fusion with resultant hybrid formation as a mechanism of melanoma metastasis (see Lazova et al., 2013) He authored nearly 200 peer-reviewed papers in the areas of skin pigmentation and melanoma metastasis and was past president of the Pan American Society for Pigment Cell Research. He published seminal works on melanocortin-1 receptors, melanocortin action and UV light, and the enzymology of melanogenesis--including discovery of the melanogenesis enzyme dopachrome tautomerase. He won several awards for this work, including the PASPCR Career Achievement Award, the IFPCS inaugural award of the Henry Stanley Raper Medal, and the JSPCR award of the Takeuchi Medal. He frequently lectured at scientific conferences in the U.S. and abroad.

Lazova et al, (2013). A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer. PLoS ONE 8(6): e66731. doi:10.1371/journal.pone.0066731.

LaBerge GS, Duvall E, Grasmick Z, Haedicke K, Pawelek J (2017) A Melanoma Lymph Node Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: A Second Case of Leucocyte-Tumor Cell Hybridization in Cancer Metastasis. PLoS ONE 12 (1): e0168581. doi:10.1371/journal.pone.0168581

Yale press release: http://news.yale.edu/2013/06/26/how-cancer-spreads-metastatic-tumor-hybrid-cancer-cell-and-white-blood-cell.

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In Memoriam: John Mason Pawelek, PhD 1942–2021

John Mason Pawelek, 79, beloved husband of Linda Jane Pawelek, and long-time member of the research faculty in the Department of Dermatology, Yale School of Medicine, died Monday, May 31 of an apparent heart attack. He was born in Baltimore, Md., on April 15, 1942, the son of Stanley John Pawelek and Constance Mason Pawelek. As a child he loved sports, excelled in baseball and basketball, and did a stint as batboy for the Baltimore Orioles in 1954.

He met Linda in 1962 while singing with the Gettysburg College choir. They married in June 1964. He earned a doctorate in biology from Brown University in 1967 and eventually moved to Yale where he ran a research lab for four decades. He authored nearly 200 peer-reviewed papers and is a co-founder and past president of the Pan American Society for Pigment Cell Research (PASPCR). His research examined factors regulating skin pigmentation and, in later years, the mechanism driving metastasis in the skin cancer melanoma. He won several awards for this work, including the PASPCR Career Achievement Award, the International Federation of Pigment Cell Societies' inaugural Henry Stanley Raper Medal, and the Japanese Society for Pigment Cell Research Takeuchi Medal. He was a frequent lecturer at scientific conferences in the U.S. and abroad, including a recent tour of medical schools in Iran.

He had many fond memories: playing piano (once) with Fats Domino, a college choir tour to Europe and the USSR; marching the last five miles of the Selma to Montgomery, Ala., voting rights march behind Dr. King; antiwar protests in Washington, DC; coaching his sons' little league teams; mentoring young people at New Haven's Waverly Townhouses; singing in the New Haven Chorale; a 1984 family trip to Poland during which he met Lech Walesa; lighting fireworks; after-hours piano jams at pigment cell conferences; overcoming his addiction to alcohol; playing the cello, and watching the Baltimore Orioles and UCONN Husky basketball. He loved his church, the Unitarian Society of New Haven (USNH), where he sang in the choir, acted in plays and musicals; and taught Sunday school. He is predeceased by his sister Elaine and a granddaughter, Emma. He is survived by his wife. Linda; his sons Aaron, Josh and Nathan; his daughters-in- law Susan, Stephany and Karen; his beloved grandchildren Oliver, Mason, Aidan, Zachary and Max; his nieces Susan, Lynn and Deborah Lehman; and many other Sterner family relatives. A celebration of life will be held at a later date at USNH.


Education & Training

  • PhD
    Brown University (1968)

Departments & Organizations