Featured Publications
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
Wong H, Park K, Gola A, Baptista A, Miller C, Deep D, Lou M, Boyd L, Rudensky A, Savage P, Altan-Bonnet G, Tsang J, Germain R. A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell 2021, 184: 3981-3997.e22. PMID: 34157301, PMCID: PMC8390950, DOI: 10.1016/j.cell.2021.05.028.Peer-Reviewed Original Research
2019
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
Franco L, Gadkari M, Howe K, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser I, Moir S, Tsang J, Germain R. Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses. Journal Of Experimental Medicine 2019, 216: 384-406. PMID: 30674564, PMCID: PMC6363437, DOI: 10.1084/jem.20180595.Peer-Reviewed Original ResearchConceptsCell typesHuman cell typesPrimary human cell typesCell-specific effectsTranscriptional outputTranscriptional regulationTranscriptional responseIndividual genesB cell receptorNew mechanistic understandingTranscriptional effectsImmunomodulatory cytokine IL-10Toll-like receptor 7Cytokine IL-10Immunoglobulin lociAnti-inflammatory drugsFunctional studiesMechanistic understandingBlimp-1Immunoregulatory therapyIL-10GenesCell receptorReceptor 7Glucocorticoid action
2016
Effects of Systemically Administered Hydrocortisone on the Human Immunome
Olnes M, Kotliarov Y, Biancotto A, Cheung F, Chen J, Shi R, Zhou H, Wang E, Tsang J, Nussenblatt R. Effects of Systemically Administered Hydrocortisone on the Human Immunome. Scientific Reports 2016, 6: 23002. PMID: 26972611, PMCID: PMC4789739, DOI: 10.1038/srep23002.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCluster AnalysisDose-Response Relationship, DrugFemaleFlow CytometryGene Expression ProfilingHumansHydrocortisoneImmunophenotypingInfusions, IntravenousKiller Cells, NaturalLymphocyte CountLymphocyte SubsetsMaleMiddle AgedSignal TransductionTime FactorsT-Lymphocyte SubsetsTranscriptomeYoung AdultConceptsSystemic corticosteroid administrationNK cell numbersHigh-dimensional flow cytometryEffect of corticosteroidsNatural killer cellsT cell subsetsEffects of systemicallyImmune system parametersAdministration of hydrocortisoneNF-κB signalingPaucity of dataHuman immunomeIntravenous hydrocortisoneCorticosteroid administrationLymphocyte subsetsNK cellsKiller cellsCell subsetsHC infusionsT cellsT lymphocytesHealthy humansGlucocorticoid receptorLow dosesCorticosteroids
2015
MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network
Zhang H, Guan M, Townsend K, Huang T, An D, Yan X, Xue R, Schulz T, Winnay J, Mori M, Hirshman M, Kristiansen K, Tsang J, White A, Cypess A, Goodyear L, Tseng Y. MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network. EMBO Reports 2015, 16: 1378-1393. PMID: 26303948, PMCID: PMC4766451, DOI: 10.15252/embr.201540837.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, BrownAdipogenesisAdipose Tissue, WhiteAMP-Activated Protein KinasesAnimalsCell DifferentiationCells, CulturedCold TemperatureHumansMiceMice, TransgenicMicroRNAsMixed Function OxygenasesNerve Tissue ProteinsNuclear ProteinsOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRepressor ProteinsSignal TransductionThermogenesisTranscription FactorsConceptsBrown adipose tissueBrown adipogenesisMiR-455Potential therapeutic targetSubcutaneous white fatTransgenic mice displayBrown adipocyte differentiationMRNA microarray profilingHuman metabolic disordersMicroRNA-455Metabolic disordersWhite fatTherapeutic targetAdipose tissueMice displayCold exposureAdipocyte differentiationAdipogenic differentiationAdipogenic programMicroarray profilingAdipogenesisMitochondrial biogenesisFunction studiesKey regulatorNew regulator
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