Featured Publications
Normalizing and denoising protein expression data from droplet-based single cell profiling
Mulè M, Martins A, Tsang J. Normalizing and denoising protein expression data from droplet-based single cell profiling. Nature Communications 2022, 13: 2099. PMID: 35440536, PMCID: PMC9018908, DOI: 10.1038/s41467-022-29356-8.Peer-Reviewed Original ResearchConceptsProtein expression dataSingle-cell profiling methodsExpression dataSingle-cell profilingOligo-conjugated antibodiesTechnical noiseProtein populationCITE-seqCellular heterogeneityComprehensive dissectionDownstream analysisCell profilingDSBsSingle cellsProtein levelsProtein expressionCell populationsOpen-source R packageProfiling methodProtein countsEmpty dropletsR packageComputational analysisCellsBiological variation
2018
Immune regulation by glucocorticoids can be linked to cell-lineage-specific transcriptional responses
Franco L, Gadkari M, Howe K, Sun J, Kumar P, Kardava L, Biancotto A, Hu Z, Fraser I, Moir S, Germain R, Tsang J. Immune regulation by glucocorticoids can be linked to cell-lineage-specific transcriptional responses. The Journal Of Immunology 2018, 200: 48.7-48.7. DOI: 10.4049/jimmunol.200.supp.48.7.Peer-Reviewed Original ResearchTranscriptional responseReceptor signalingSpecific transcriptional responsesGenome-wide approachesTotal RNA sequencingSmall RNA sequencingB-cell receptor signalingCell receptor signalingExpression of genesDependent transcriptional responsesPrimary cell populationsB cellsTranscriptional regulationIndividual genesRNA sequencingToll-like receptor signalingNegative regulatorKey moleculesB cell activationHuman B cellsSingle intravenous doseProtein levelsAnti-inflammatory drugsImmune pathwaysCell populations
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