1996
Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.
Rodgers W, Rose J. Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains. Journal Of Cell Biology 1996, 135: 1515-1523. PMID: 8978819, PMCID: PMC2133949, DOI: 10.1083/jcb.135.6.1515.Peer-Reviewed Original ResearchConceptsExclusion of CD45Low kinase activityGEM fractionMembrane domainsKinase activitySrc family tyrosine kinasesReservoir of enzymesSpecific membrane domainsActivity of p56lckTyrosine phosphatase CD45Family tyrosine kinasesT cell developmentTX-100-soluble fractionGEM domainsPhosphatase CD45Membrane proteinsKinase specific activityLckTyrosine kinaseMembrane fractionJurkat cellsPeptide mappingP56lckPhosphorylationHyperphosphorylation
1992
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Brown D, Rose J. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 1992, 68: 533-544. PMID: 1531449, DOI: 10.1016/0092-8674(92)90189-j.Peer-Reviewed Original ResearchConceptsBasolateral marker proteinsCertain membrane proteinsApical cell surfaceDetergent-insoluble formGlycosylphosphatidyl inositol (GPI) anchorMembrane subdomainsMembrane proteinsIntracellular associationGolgi complexMicrodomains formGolgi apparatusInositol anchorMarker proteinsCell surfaceProteinApical surfaceEpithelial cellsGPIGlycosphingolipidsComplexesVesiclesLysatesGlycolipidsSortingMembrane