1993
Folding and Assembly of Viral Membrane Proteins
Doms R, Lamb R, Rose J, Helenius A. Folding and Assembly of Viral Membrane Proteins. Virology 1993, 193: 545-562. PMID: 8460475, DOI: 10.1006/viro.1993.1164.Peer-Reviewed Original ResearchConceptsViral membrane proteinsQuality control mechanismsMolecular chaperonesGRP78-BiPMembrane proteinsER molecular chaperonesEffects of mutationsMisfolded proteinsProtein transportConformational maturationMisfolded moleculesProtein foldingEnergy-driven processChaperonesProtein structureMolecular mechanismsER environmentGRP78 synthesisExogenous proteinsNascent moleculesProteinDirect roleStructural variabilityControl mechanismsExperimental strategies
1987
An internalized amino-terminal signal sequence retains full activity in vivo but not in vitro.
Rottier P, Florkiewicz R, Shaw A, Rose J. An internalized amino-terminal signal sequence retains full activity in vivo but not in vitro. Journal Of Biological Chemistry 1987, 262: 8889-8895. PMID: 3036834, DOI: 10.1016/s0021-9258(18)47498-4.Peer-Reviewed Original ResearchConceptsSignal sequenceAmino-terminal signal sequenceAmino-terminal presequenceAmino-terminal extensionAmino-terminal coding sequenceVesicular stomatitis virus glycoproteinWild-type efficiencyEukaryotic cellsMembrane insertionSignal peptideCoding sequenceSignal cleavageAmino acidsVirus glycoproteinFull activitySequenceVivoGlycoproteinPresequenceSubsequent transportCleavageGlycosylationInternalizationSuch constructsCells
1981
Conditional expression of the vesicular stomatitis virus glycoprotein gene in Escherichia coli.
Rose J, Shafferman A. Conditional expression of the vesicular stomatitis virus glycoprotein gene in Escherichia coli. Proceedings Of The National Academy Of Sciences Of The United States Of America 1981, 78: 6670-6674. PMID: 6273881, PMCID: PMC349111, DOI: 10.1073/pnas.78.11.6670.Peer-Reviewed Original ResearchConceptsGlycoprotein geneEscherichia coliNH2-terminal domainTryptic peptide mappingRegulatory regionsProtein sequencesBacterial plasmidsCOOH terminusGene regionG proteinsConditional expressionAmino acidsProteinHydrophobic segmentsPeptide mappingPlasmidStomatitis virusGenesDeletionColiLethalitySequenceExpressionAntigenic determinantsTerminusNucleotide sequences of the mRNA's encoding the vesicular stomatitis virus N and NS proteins
Gallione C, Greene J, Iverson L, Rose J. Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus N and NS proteins. Journal Of Virology 1981, 39: 529-535. PMID: 6268841, PMCID: PMC171363, DOI: 10.1128/jvi.39.2.529-535.1981.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceDNAProtein BiosynthesisRNA, MessengerRNA, ViralVesicular stomatitis Indiana virusViral ProteinsConceptsNS proteinsAUG codonReading frameNucleotide sequenceThird AUG codonAmino acidsComplete nucleotide sequenceVesicular stomatitis virus mRNAOpen reading frameSodium dodecyl sulfate-polyacrylamide gelsAnomalous electrophoretic mobilityDodecyl sulfate-polyacrylamide gelsSecond reading frameSulfate-polyacrylamide gelsCDNA clonesTranslational initiationSmall proteinsMRNA sequencesN proteinVirus NPolyadenylic acidVirus mRNACodonProteinMRNA
1980
Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.
Trachsel H, Sonenberg N, Shatkin A, Rose J, Leong K, Bergmann J, Gordon J, Baltimore D. Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 770-774. PMID: 6244584, PMCID: PMC348362, DOI: 10.1073/pnas.77.2.770.Peer-Reviewed Original ResearchComplete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus
Rose J. Complete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus. Cell 1980, 19: 415-421. PMID: 6244108, DOI: 10.1016/0092-8674(80)90515-2.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCloning, MolecularGenes, ViralProtein BiosynthesisRibosomesRNA CapsRNA, MessengerRNA, ViralVesicular stomatitis Indiana virusConceptsGene sequencesPossible promoter sequenceFrame AUG codonsIntergenic regionTranscription eventsVSV transcriptionPromoter sequencesExtensive homologyMRNA structurePolyadenylation signalNucleotide sequenceAUG codonVesicular stomatitis virusL geneRNA regionsMRNA sequencesVSV genesTerminal sequenceVSV mRNAsN mRNAStomatitis virusG mRNAMRNARibosomesVariable positions
1978
Inhibition of translation by poliovirus: inactivation of a specific initiation factor.
Rose J, Trachsel H, Leong K, Baltimore D. Inhibition of translation by poliovirus: inactivation of a specific initiation factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1978, 75: 2732-2736. PMID: 208073, PMCID: PMC392637, DOI: 10.1073/pnas.75.6.2732.Peer-Reviewed Original ResearchConceptsUninfected cellsHost mRNA translationPoliovirus infectionVSV mRNAsUninfected HeLa cellsInfected cellsSelective inhibitionSlow inactivationMixed extractPoliovirus-induced inhibitionInhibitionMRNACellsPoliovirusLysatesProtein synthesisMRNA translationInitiation factorsInhibition of translationExtractTranslation initiation factor