2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2019
Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine
Barahona MJ, Maina RM, Lysyy T, Finotti M, Caturegli G, Baratta V, D’Amico F, Mulligan D, Geibel JP. Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. Frontiers In Physiology 2019, 10: 439. PMID: 31130866, PMCID: PMC6509940, DOI: 10.3389/fphys.2019.00439.Peer-Reviewed Original ResearchPresence of forskolinFluid secretionSmall intestineAC-265347Fluid absorptionIntestinal fluid secretionCalcium-sensing receptorSprague-Dawley ratsNew therapeutic targetsNet fluid absorptionDose-dependent mannerRat small intestineMM CaAbsence of forskolinMammalian gastrointestinal tractFluid hypersecretionDiarrheal illnessIntraluminal perfusionPotent secretagogueDawley ratsGastrointestinal tractCaSR activatorsElectrolyte balanceTherapeutic targetLuminal perfusate
2018
Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine
Finotti M, Lysyy T, Caturegli G, Barahona M, Maina R, D'Amico F, Mulligan D, Geibel J. Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine. Transplantation 2018, 102: s669. DOI: 10.1097/01.tp.0000543607.00911.f4.Peer-Reviewed Original ResearchOral rehydration solutionSmall intestineColon segmentsIntestinal secretionNumerous body tissuesSeverity of diarrheaDistal small intestineMale Sprague-DawleyCalcium-sensing receptorDistal portionLuminal calcium concentrationRat small intestineAbsence of forskolinCalcium perfusionProphylactic therapyAntibiotic therapyLeading causePotent secretagogueRehydration solutionSprague-DawleyElectrolyte homeostasisDiarrheaPotential treatmentSecretion profileAbsorption of fluidPrevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segmentsSa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine
Lysyy T, Caturegli G, Finotti M, Maina R, Barahona M, D'Amico F, Mulligan D, Geibel J. Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine. Gastroenterology 2018, 154: s-269-s-270. DOI: 10.1016/s0016-5085(18)31261-7.Peer-Reviewed Original ResearchTu1257 - Three-Dimensional Printed Biopatches are Viable Conduits for Repair of small Intestinal Injuries in a Rat Model
Maina R, Geibel P, Lysyy T, Finotti M, Wengerter B, Barahona M, Caturegli G, Geibel J. Tu1257 - Three-Dimensional Printed Biopatches are Viable Conduits for Repair of small Intestinal Injuries in a Rat Model. Gastroenterology 2018, 154: s-917. DOI: 10.1016/s0016-5085(18)33083-x.Peer-Reviewed Original Research
2017
Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury
Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP. Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Frontiers In Physiology 2017, 8: 1064. PMID: 29311987, PMCID: PMC5742259, DOI: 10.3389/fphys.2017.01064.Peer-Reviewed Original ResearchIschemic injuryIntestinal ischemiaProtective effectIntestinal ischemic injuryLight-level microscopyEosin-stained sectionsLactate administrationAntibiotic treatmentIschemic protectionIntestinal barrierLactate perfusionRat modelIntestinal microbiomeIntestinal preservationIntestinal segmentsIschemic cellsSmall intestineInert sugarsInjuryIschemiaPerfusionEpithelium morphologySecretionPerfusion deviceFITC-inulinSa1982 Elevated no Production is Protective Against Small Intestine Ischemic Injury
Ibarra C, Caturegli G, Abraham A, Rodriguez-Davalos M, Mulligan D, Geibel J. Sa1982 Elevated no Production is Protective Against Small Intestine Ischemic Injury. Gastroenterology 2017, 152: s415-s416. DOI: 10.1016/s0016-5085(17)31617-7.Peer-Reviewed Original Research
2016
Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury
AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP. Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. Journal Of The American College Of Surgeons 2016, 224: 1066-1073. PMID: 28017811, DOI: 10.1016/j.jamcollsurg.2016.12.016.Peer-Reviewed Original ResearchConceptsFluorescein isothiocyanate-inulinIschemic injuryIntestinal ischemiaIntestinal transplantationFluid secretionIntestinal ischemic injuryIntestinal tissue samplesSmall intestine segmentsHEPES-Ringer solutionIntestinal graftMesenteric ischemiaIschemic intestineHistopathologic samplesExperimental armControl armControl intestineIschemic stateBlinded pathologistIschemiaIntestinal lumenIntestinal tissueIntestine segmentsScoring systemFluid shiftsInjuryUse of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability
AlKukhun A, Bertacco A, Abraham A, Caturegli G, D'Amico F, Rodriguez-Davalos M, Mulligan D, Geibel J. Use of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability. Journal Of The American College Of Surgeons 2016, 223: e193. DOI: 10.1016/j.jamcollsurg.2016.08.489.Peer-Reviewed Original ResearchSu1913 Stimulation of the Intestinal Microbiome By Lactate Perfusion Prevents Ischemic Injury
Geibel J, Dehner C, Bertacco A, Caturegli G, Kriegel M, Rodriguez-Davalos M, D'Amico F. Su1913 Stimulation of the Intestinal Microbiome By Lactate Perfusion Prevents Ischemic Injury. Gastroenterology 2016, 150: s586-s587. DOI: 10.1016/s0016-5085(16)32012-1.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply