2023
CRITICALITIES AND USEFULNESS OF EX-VIVO SMALL INTESTINE PERFUSION: TRANSPLANT AND BEYOND
Muñoz-Abraham A, Martinez A, Aviles-Ovalle B, Patron-Lozano R, D’Amico F, Geibel J, Mulligan D, Martins P, Rodriguez-Davalos M. CRITICALITIES AND USEFULNESS OF EX-VIVO SMALL INTESTINE PERFUSION: TRANSPLANT AND BEYOND. European Journal Of Transplantation 2023, 1: 126-135. DOI: 10.57603/ejt-015.Peer-Reviewed Original Research
2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2021
Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario
D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.Peer-Reviewed Original ResearchBile microbiotaLiver donorsBiliary tract diseaseCommon bile ductGene amplificationRibosomal RNA gene amplificationLiver recipientsLiver transplantationPediatric recipientsLiver proceduresBiliary tractBile ductRecipient patientsTract diseaseBile samplesHeterogeneous cohortClinical scenariosBileSterile wayPCR sequencingPatientsRecipientsMicrobiotaTransplantationGallbladder
2020
Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt
Baratta VM, Norz V, Barahona MJ, Gisinger TM, Mulligan D, Geibel JP. Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt. Cellular Physiology And Biochemistry 2020, 54: 1132-1142. PMID: 33175479, PMCID: PMC8095381, DOI: 10.33594/000000305.Peer-Reviewed Original ResearchConceptsRat colonic cryptsColonic cryptsNitric oxideNitric oxide-dependent mechanismPotassium homeostasisArginine methyl esterAmmonium prepulse techniqueIntracellular nitric oxideSodium-free conditionsL-NAMEDiarrheal statesATPase activityBACKGROUND/Presence of NOPenicillin G sodium saltAcute exposureL-arginineSmall intestineIsolated administrationN-nitroHomeostatic conditionsCryptsPrepulse techniqueSignificant reductionNovel mechanismHuman Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions
Lysyy T, Finotti M, Maina RM, Morotti R, Munoz-Abraham AS, Bertacco A, Ibarra C, Barahona M, Agarwal R, D'Amico F, Rodriguez-Davalos MI, Mulligan D, Geibel J. Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions. Transplantation Proceedings 2020, 52: 2934-2940. PMID: 32768284, DOI: 10.1016/j.transproceed.2020.06.031.Peer-Reviewed Original ResearchConceptsContinuous perfusion preservationIntestinal graftIschemic damagePerfusion preservationAppropriate graft selectionCold static storageSmall intestinal graftsSmall intestine graftDifferent preservation solutionsBlinded histological evaluationCross clampIntestine graftsPostoperative complicationsDifferent time pointsIschemic injuryDeceased donorsPatient survivalGraft selectionRinger's lactateHistological evaluationBack tableVascular perfusionLuminal flushAbdominal organsSmall intestine
2019
Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine
Barahona MJ, Maina RM, Lysyy T, Finotti M, Caturegli G, Baratta V, D’Amico F, Mulligan D, Geibel JP. Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. Frontiers In Physiology 2019, 10: 439. PMID: 31130866, PMCID: PMC6509940, DOI: 10.3389/fphys.2019.00439.Peer-Reviewed Original ResearchPresence of forskolinFluid secretionSmall intestineAC-265347Fluid absorptionIntestinal fluid secretionCalcium-sensing receptorSprague-Dawley ratsNew therapeutic targetsNet fluid absorptionDose-dependent mannerRat small intestineMM CaAbsence of forskolinMammalian gastrointestinal tractFluid hypersecretionDiarrheal illnessIntraluminal perfusionPotent secretagogueDawley ratsGastrointestinal tractCaSR activatorsElectrolyte balanceTherapeutic targetLuminal perfusateMo1102 – Aspirin and Ischemia in the Murine Distal Colon
Baratta V, Barahona M, Mulligan D, Geibel J. Mo1102 – Aspirin and Ischemia in the Murine Distal Colon. Gastroenterology 2019, 156: s-708. DOI: 10.1016/s0016-5085(19)38700-1.Peer-Reviewed Original ResearchSa1745 – Glacial Acetic Acid-Induced Ulcerative Colitis Lesions Improve After Oral Calcium Nanoparticle Therapy in a Rat Model
Barahona M, Baratta V, Mulligan D, Geibel J. Sa1745 – Glacial Acetic Acid-Induced Ulcerative Colitis Lesions Improve After Oral Calcium Nanoparticle Therapy in a Rat Model. Gastroenterology 2019, 156: s-384. DOI: 10.1016/s0016-5085(19)37812-6.Peer-Reviewed Original ResearchSa1746 – Oral Calcium Nanoparticle Therapy Aids in the Recovery from Dss-Induced Ulcerative Colitis in the Rat Model
Baratta V, Barahona M, Mulligan D, Geibel J. Sa1746 – Oral Calcium Nanoparticle Therapy Aids in the Recovery from Dss-Induced Ulcerative Colitis in the Rat Model. Gastroenterology 2019, 156: s-384-s-385. DOI: 10.1016/s0016-5085(19)37813-8.Peer-Reviewed Original ResearchDesign and implementation of novel nutraceuticals and derivatives for treating intestinal disorders
Barahona MJ, Baratta V, Ollodart J, Mulligan D, Geibel JP. Design and implementation of novel nutraceuticals and derivatives for treating intestinal disorders. Future Medicinal Chemistry 2019, 11: 847-855. PMID: 30994367, PMCID: PMC8008207, DOI: 10.4155/fmc-2018-0313.Peer-Reviewed Original ResearchConceptsSignificant worldwide disease burdenSpectrum of illnessWorldwide disease burdenIntestinal fluid secretionSystemic side effectsCalcium-sensing receptorNovel therapeutic targetG protein-coupled receptorsSurgical therapyPharmaceutical optionsMucosal integrityDisease burdenIntestinal disordersNutraceutical therapyGastrointestinal diseasesGastrointestinal illnessSide effectsTherapeutic targetFluid secretionIntestinal cellsTherapyAdverse effectsNovel nutraceuticalsCaSRIllness
2018
Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine
Finotti M, Lysyy T, Caturegli G, Barahona M, Maina R, D'Amico F, Mulligan D, Geibel J. Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine. Transplantation 2018, 102: s669. DOI: 10.1097/01.tp.0000543607.00911.f4.Peer-Reviewed Original ResearchOral rehydration solutionSmall intestineColon segmentsIntestinal secretionNumerous body tissuesSeverity of diarrheaDistal small intestineMale Sprague-DawleyCalcium-sensing receptorDistal portionLuminal calcium concentrationRat small intestineAbsence of forskolinCalcium perfusionProphylactic therapyAntibiotic therapyLeading causePotent secretagogueRehydration solutionSprague-DawleyElectrolyte homeostasisDiarrheaPotential treatmentSecretion profileAbsorption of fluidPrevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segmentsGenerating vascular conduits: from tissue engineering to three-dimensional bioprinting
Maina RM, Barahona MJ, Finotti M, Lysyy T, Geibel P, D’Amico F, Mulligan D, Geibel JP. Generating vascular conduits: from tissue engineering to three-dimensional bioprinting. Innovative Surgical Sciences 2018, 3: 203-213. PMID: 31579784, PMCID: PMC6604577, DOI: 10.1515/iss-2018-0016.Peer-Reviewed Original ResearchArtery diseaseVascular conduitsVascular diseaseAutologous graftsNative vesselsSuitable vascular conduitInternal mammary arteryPeripheral vascular diseaseRat vascular smooth muscle cellsThird of patientsCoronary artery diseaseCarotid artery diseaseVascular smooth muscle cellsStandard of careLimb-saving procedureSmooth muscle cellsMultivessel diseaseDonor graftsMammary arteryPoor outcomeSaphenous veinLeading causeVascular interventionsGraftMuscle cellsSa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine
Lysyy T, Caturegli G, Finotti M, Maina R, Barahona M, D'Amico F, Mulligan D, Geibel J. Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine. Gastroenterology 2018, 154: s-269-s-270. DOI: 10.1016/s0016-5085(18)31261-7.Peer-Reviewed Original Research
2017
Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury
Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP. Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Frontiers In Physiology 2017, 8: 1064. PMID: 29311987, PMCID: PMC5742259, DOI: 10.3389/fphys.2017.01064.Peer-Reviewed Original ResearchIschemic injuryIntestinal ischemiaProtective effectIntestinal ischemic injuryLight-level microscopyEosin-stained sectionsLactate administrationAntibiotic treatmentIschemic protectionIntestinal barrierLactate perfusionRat modelIntestinal microbiomeIntestinal preservationIntestinal segmentsIschemic cellsSmall intestineInert sugarsInjuryIschemiaPerfusionEpithelium morphologySecretionPerfusion deviceFITC-inulinSa1982 Elevated no Production is Protective Against Small Intestine Ischemic Injury
Ibarra C, Caturegli G, Abraham A, Rodriguez-Davalos M, Mulligan D, Geibel J. Sa1982 Elevated no Production is Protective Against Small Intestine Ischemic Injury. Gastroenterology 2017, 152: s415-s416. DOI: 10.1016/s0016-5085(17)31617-7.Peer-Reviewed Original Research3D Bioprinting in Transplantation
Munoz-Abraham A, Ibarra C, Agarwal R, Geibel J, Mulligan D. 3D Bioprinting in Transplantation. 2017, 261-276. DOI: 10.1007/978-3-319-62142-5_11.Peer-Reviewed Original Research
2016
Is Normothermic Perfusion a Feasible Option for Intestinal Preservation? Experience with a Porcine Model
Bertacco A, AlKukhun A, Kitay A, Aldajani M, D'Amico F, Rodriguez-Davalos M, Mulligan D, Geibel J. Is Normothermic Perfusion a Feasible Option for Intestinal Preservation? Experience with a Porcine Model. Journal Of The American College Of Surgeons 2016, 223: e50-e51. DOI: 10.1016/j.jamcollsurg.2016.08.147.Peer-Reviewed Original ResearchUse of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability
AlKukhun A, Bertacco A, Abraham A, Caturegli G, D'Amico F, Rodriguez-Davalos M, Mulligan D, Geibel J. Use of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability. Journal Of The American College Of Surgeons 2016, 223: e193. DOI: 10.1016/j.jamcollsurg.2016.08.489.Peer-Reviewed Original Research3D Printing of Organs for Transplantation: Where Are We and Where Are We Heading?
Munoz-Abraham A, Rodriguez-Davalos M, Bertacco A, Wengerter B, Geibel J, Mulligan D. 3D Printing of Organs for Transplantation: Where Are We and Where Are We Heading? Current Transplantation Reports 2016, 3: 93-99. DOI: 10.1007/s40472-016-0089-6.Peer-Reviewed Original Research
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