1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashion
1996
Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics.
Braxton J, Higgins R, Schwann T, Sanchez J, Dewar M, Kopf G, Hammond G, Letsou G, Elefteriades J. Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics. The Journal Of Heart Valve Disease 1996, 5: 169-73. PMID: 8665010.Peer-Reviewed Original ResearchConceptsMitral valve surgeryReoperative mitral valve surgeryRight thoracotomy approachThoracotomy approachBlood lossValve surgeryInotropic supportBypass timeThoracotomy patientsRight thoracotomyOperative timeRight antero-lateral thoracotomyUnderwent mitral valve replacementPaO2/FiO2 ratioRedo mitral valve surgeryBioprosthetic valve failureProlonged hospital courseSevere pulmonary dysfunctionSignificant inotropic supportCardiopulmonary bypass timeLength of ICUMitral valve proceduresMitral valve replacementCoronary artery graftsExcessive blood loss