1995
The effects of weight reduction to ideal body weight on body fat distribution
Hendler R, Welle S, Statt M, Barnard R, Amatruda J. The effects of weight reduction to ideal body weight on body fat distribution. Metabolism 1995, 44: 1413-1416. PMID: 7476327, DOI: 10.1016/0026-0495(95)90139-6.Peer-Reviewed Original ResearchConceptsIdeal body weightSubcutaneous fat areaBody mass indexFat areaObese womenFat distributionObese subjectsBody fatBody weightUpper body fat distributionIntraabdominal fat areaObese control subjectsBody fat distributionPercent body fatHealth risk factorsWeight reductionObese groupMass indexHip ratioControl subjectsRisk factorsMetabolic disordersControl groupWeight lossObese
1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1985
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
Amatruda J, Livingston J, Lockwood D. Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure. Diabetes/Metabolism Research And Reviews 1985, 1: 293-317. PMID: 3915256, DOI: 10.1002/dmr.5610010304.Peer-Reviewed Original Research
1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
Lockwood D, Amatruda J. Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus. The American Journal Of Medicine 1983, 75: 23-31. PMID: 6369965, DOI: 10.1016/0002-9343(83)90250-4.Peer-Reviewed Original ResearchConceptsType II diabetes mellitusInsulin resistanceDiabetes mellitusRelative insulin deficiencyBlood sugar levelsInsulin-resistant statesInsulin deficiencyMetabolic controlResistant stateMellitusSugar levelsCellular alterationsEfficacious methodRecent evidenceObesityPathophysiologyAlterationsNumerous studiesFuture effortsClear understandingProminent featureVigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion
Amatruda J, Biddle T, Patton M, Lockwood D. Vigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion. The American Journal Of Medicine 1983, 74: 1016-1022. PMID: 6859052, DOI: 10.1016/0002-9343(83)90804-5.Peer-Reviewed Original ResearchConceptsCardiac arrhythmiasLiquid protein dietWeight maintenance dietIdeal body weightLife-threatening cardiac arrhythmiasExperimental dietsHypocaloric dietMetabolic wardCardiac changesEssential fatty acidsObese femalesElectrocardiographic recordingsCardiac rhythmBody weightVigorous supplementationArrhythmiasMaintenance dietProtein dietDaily allowanceDietHypocaloricEight-day periodSubjectsFatty acidsSignificant changesEffects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin
Kelleher P, Phinney S, Sims E, Bogardus C, Horton E, Bistrian B, Amatruda J, Lockwood D. Effects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin. Metabolism 1983, 32: 95-101. PMID: 6401350, DOI: 10.1016/0026-0495(83)90163-4.Peer-Reviewed Original ResearchConceptsCarbohydrate-restricted dietCarbohydrate-containing dietRetinol-binding proteinSerum concentrationsThyroxine-binding prealbuminGroup IGroup IISignificant decreaseObese individuals resultsNormal-weight subjectsGroup I subjectsNormal-weight individualsControl diet periodSerum albumin concentrationEffect of dietEucaloric dietObese subjectsIsocaloric substitutionWeight subjectsDiet periodVisceral proteinsWeight individualsTBPA concentrationsCaloric intakeAlbumin concentration
1980
Cardiac Arrhythmias Associated with a Liquid Protein Diet for the Treatment of Obesity
Lantigua R, Amatruda J, Biddle T, Forbes G, Lockwood D. Cardiac Arrhythmias Associated with a Liquid Protein Diet for the Treatment of Obesity. New England Journal Of Medicine 1980, 303: 735-738. PMID: 7402271, DOI: 10.1056/nejm198009253031305.Peer-Reviewed Original ResearchInsulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin response
1978
Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity
Moxley R, Lockwood D, Amatruda J, Tobin J, Pozefsky T. Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity. Diabetes 1978, 27: 78-84. PMID: 624443, DOI: 10.2337/diab.27.2.78.Peer-Reviewed Original ResearchConceptsJejunoileal bypass surgeryInsulin responseAmino acid elevationMorbid obesityBypass surgeryIntravenous amino acidsAmino acid ingestionBasal insulin concentrationsAmino acid loadPortion of jejunumAcid tolerance testIntravenous loadAcid ingestionPreoperative valuesTolerance testInsulin concentrationsInsulin secretionAmino acid loadingInsulin releasePeak insulinPercentage increasePeak incrementAcid loadSurgeryObesity
1975
Insulin Receptor: Role in the Resistance of Human Obesity to Insulin
Amatruda J, Livingston J, Lockwood D. Insulin Receptor: Role in the Resistance of Human Obesity to Insulin. Science 1975, 188: 264-266. PMID: 164059, DOI: 10.1126/science.164059.Peer-Reviewed Original Research
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