1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibition
1985
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
Amatruda J, Livingston J, Lockwood D. Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure. Diabetes/Metabolism Research And Reviews 1985, 1: 293-317. PMID: 3915256, DOI: 10.1002/dmr.5610010304.Peer-Reviewed Original Research
1984
Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats
Salhanick A, Konowitz P, Amatruda J. Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats. Diabetes 1983, 32: 206-212. PMID: 6337899, DOI: 10.2337/diab.32.3.206.Peer-Reviewed Original ResearchConceptsDiabetic ratsInsulin actionInsulin responsivenessPrimary culturesStreptozotocin-diabetic ratsHepatic insulin resistanceDose-dependent increaseInsulin-dependent actionInsulin-stimulated ratesDependent diabetesDiabetic animalsInsulin resistanceNondiabetic animalsInsulin sensitivityAbsence of insulinInsulin secretionSignificant potentiationNormal ratsChronic exposureSpecific insulinRatsSerum-free mediumInsulinSulfonylurea tolazamideSulfonylureasThe regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats
Amatruda J, Chang C. The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats. Metabolism 1983, 32: 224-229. PMID: 6402645, DOI: 10.1016/0026-0495(83)90186-5.Peer-Reviewed Original ResearchConceptsDiabetic ratsDiabetic animalsInsulin responsivenessChronic exposurePrimary culturesAcute effectsBasal lipogenesisStreptozotocin-diabetic ratsStreptozotocin-diabetic animalsLipid synthesisNormal control animalsPresence of insulinInsulin resistanceLipogenic responseInsulin administrationNormal ratsControl animalsNormal controlsNormal animalsRatsFasted ratsInsulinAcute responsivenessLipogenesisM insulin
1982
Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes
Amatruda J, Newmeyer H, Chang C. Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes. Diabetes 1982, 31: 145-148. PMID: 6759230, DOI: 10.2337/diab.31.2.145.Peer-Reviewed Original Research
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