1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1985
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
Amatruda J, Livingston J, Lockwood D. Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure. Diabetes/Metabolism Research And Reviews 1985, 1: 293-317. PMID: 3915256, DOI: 10.1002/dmr.5610010304.Peer-Reviewed Original Research
1984
Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2Drug SynergismHumansInsulinInsulin ResistanceLipidsLiverProteinsRatsRats, Inbred StrainsTime FactorsTolazamideConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
Lockwood D, Amatruda J. Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus. The American Journal Of Medicine 1983, 75: 23-31. PMID: 6369965, DOI: 10.1016/0002-9343(83)90250-4.Peer-Reviewed Original ResearchConceptsType II diabetes mellitusInsulin resistanceDiabetes mellitusRelative insulin deficiencyBlood sugar levelsInsulin-resistant statesInsulin deficiencyMetabolic controlResistant stateMellitusSugar levelsCellular alterationsEfficacious methodRecent evidenceObesityPathophysiologyAlterationsNumerous studiesFuture effortsClear understandingProminent featureInsulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase
Amatruda J, Chang C. Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase. Biochemical And Biophysical Research Communications 1983, 112: 35-41. PMID: 6340685, DOI: 10.1016/0006-291x(83)91793-x.Peer-Reviewed Original ResearchConceptsInsulin resistanceLiver particulate fractionDiabetes mellitusRelease of mediatorsFailure of insulinEffect of insulinAbility of insulinDiabetic animalsInsulin treatmentControl animalsParticulate fractionPyruvate dehydrogenase activityInsulinLiverMellitusFastingDehydrogenase activityAnimalsPyruvate dehydrogenaseThe regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats
Amatruda J, Chang C. The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats. Metabolism 1983, 32: 224-229. PMID: 6402645, DOI: 10.1016/0026-0495(83)90186-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDiabetes Mellitus, ExperimentalDiabetic KetoacidosisFastingInsulin ResistanceLipidsLiverMaleRatsRats, Inbred StrainsConceptsDiabetic ratsDiabetic animalsInsulin responsivenessChronic exposurePrimary culturesAcute effectsBasal lipogenesisStreptozotocin-diabetic ratsStreptozotocin-diabetic animalsLipid synthesisNormal control animalsPresence of insulinInsulin resistanceLipogenic responseInsulin administrationNormal ratsControl animalsNormal controlsNormal animalsRatsFasted ratsInsulinAcute responsivenessLipogenesisM insulin
1975
Insulin Receptor: Role in the Resistance of Human Obesity to Insulin
Amatruda J, Livingston J, Lockwood D. Insulin Receptor: Role in the Resistance of Human Obesity to Insulin. Science 1975, 188: 264-266. PMID: 164059, DOI: 10.1126/science.164059.Peer-Reviewed Original Research
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