1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1989
Insulin and steatonecrosis: Are they related?
Amatruda J, Salhanick A. Insulin and steatonecrosis: Are they related? Hepatology 1989, 10: 1024-1025. PMID: 2684837, DOI: 10.1002/hep.1840100627.Peer-Reviewed Original ResearchConceptsFree fatty acidsIntraperitoneal insulinInsulin secretionAdipose tissueType II diabetes mellitusMarked weight lossPeritoneal dialysis patientsSetting of obesityNon-alcoholic individualsPathogenesis of steatosisConcentrations of insulinType II diabetesJejunoileal bypassObese patientsRenal failureDiabetes mellitusDialysis patientsCAPD patientsHepatic histologyPresence of insulinFFA mobilizationHepatic steatosisIntraperitoneal administrationPortal veinInsulin concentrations
1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibition
1986
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes
Sparks C, Sparks J, Bolognino M, Salhanick A, Strumph P, Amatruda J. Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes. Metabolism 1986, 35: 1128-1136. PMID: 3537632, DOI: 10.1016/0026-0495(86)90026-0.Peer-Reviewed Original ResearchConceptsLipoprotein synthesisPostprandial insulin releasePrimary culturesHepatic lipoprotein secretionEffect of insulinApo B secretionLipoprotein metabolic pathwaysAddition of insulinApo B massMonoclonal radioimmunoassayInsulin concentrationsVLDL secretionMedia insulin concentrationsB secretionApolipoprotein BInsulin releaseLipid secretionLipoprotein secretionDensity lipoproteinLipid radioactivityPhysiologic concentrationsRat hepatocytesLipoprotein apoproteinsInsulinInsulin effect
1985
Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus
Amatruda J, Roncone A. Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus. Biochemical And Biophysical Research Communications 1985, 129: 163-170. PMID: 3890853, DOI: 10.1016/0006-291x(85)91417-2.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceNonketotic diabetes mellitusInability of insulinDiabetes mellitusInsulin resistanceInsulin receptor autophosphorylationInsulin actionPutative mediatorsStreptozotocin-induced diabetes mellitusReceptor autophosphorylationDose-response relationshipInsulin receptor bindingAbility of insulinMembrane insulin receptorsDiabetic animalsInsulin treatmentInsulin dose-response relationshipInsulin bindingMellitusPlasma membrane insulin receptorsInsulinReceptor bindingInsulin receptor
1984
Treatment of Insulin Reactions in Diabetics
Brodows R, Williams C, Amatruda J. Treatment of Insulin Reactions in Diabetics. JAMA 1984, 252: 3378-3381. PMID: 6389915, DOI: 10.1001/jama.1984.03350240024032.Peer-Reviewed Original ResearchConceptsGlycemic responsePlasma free insulin concentrationInsulin-dependent diabeticsFree insulin concentrationsMicroU/mLGlucose clamp techniquePlasma glucose levelsRebound hyperglycemiaSevere hypoglycemiaOutpatient settingSpontaneous episodesInsulin concentrationsInsulin reactionGlucose levelsClamp techniqueHypoglycemiaIngested carbohydrateD-glucoseDiabeticsOrange juiceTreatmentImportant determinantCommon sourceHyperglycemiaPatientsHepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
Lockwood D, Amatruda J. Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus. The American Journal Of Medicine 1983, 75: 23-31. PMID: 6369965, DOI: 10.1016/0002-9343(83)90250-4.Peer-Reviewed Original ResearchConceptsType II diabetes mellitusInsulin resistanceDiabetes mellitusRelative insulin deficiencyBlood sugar levelsInsulin-resistant statesInsulin deficiencyMetabolic controlResistant stateMellitusSugar levelsCellular alterationsEfficacious methodRecent evidenceObesityPathophysiologyAlterationsNumerous studiesFuture effortsClear understandingProminent featureInsulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase
Amatruda J, Chang C. Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase. Biochemical And Biophysical Research Communications 1983, 112: 35-41. PMID: 6340685, DOI: 10.1016/0006-291x(83)91793-x.Peer-Reviewed Original ResearchConceptsInsulin resistanceLiver particulate fractionDiabetes mellitusRelease of mediatorsFailure of insulinEffect of insulinAbility of insulinDiabetic animalsInsulin treatmentControl animalsParticulate fractionPyruvate dehydrogenase activityInsulinLiverMellitusFastingDehydrogenase activityAnimalsPyruvate dehydrogenasePotentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats
Salhanick A, Konowitz P, Amatruda J. Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats. Diabetes 1983, 32: 206-212. PMID: 6337899, DOI: 10.2337/diab.32.3.206.Peer-Reviewed Original ResearchConceptsDiabetic ratsInsulin actionInsulin responsivenessPrimary culturesStreptozotocin-diabetic ratsHepatic insulin resistanceDose-dependent increaseInsulin-dependent actionInsulin-stimulated ratesDependent diabetesDiabetic animalsInsulin resistanceNondiabetic animalsInsulin sensitivityAbsence of insulinInsulin secretionSignificant potentiationNormal ratsChronic exposureSpecific insulinRatsSerum-free mediumInsulinSulfonylurea tolazamideSulfonylureas
1982
Glucocorticoid-induced Insulin Resistance
F. J, Amatruda J. Glucocorticoid-induced Insulin Resistance. Journal Of Clinical Investigation 1982, 69: 866-875. PMID: 7042756, PMCID: PMC370141, DOI: 10.1172/jci110526.Peer-Reviewed Original ResearchConceptsAbility of insulinControl animalsInsulin bindingInsulin degradationDexamethasone treatmentNormal ratsInsulin receptorInsulin actionAminoisobutyrate uptakeWeight-matched control animalsGlucocorticoid-induced insulin resistancePrimary culturesAdministration of dexamethasoneDexamethasone-treated animalsPresence of hyperinsulinemiaEffect of insulinCellular insulin receptorsDose-response curveHepatocyte insulin receptorsSignificant hyperinsulinemiaInsulin resistanceAbsence of dexamethasoneLess insulinInsulin concentrationsVivo hyperinsulinemiaInsulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes
Amatruda J, Newmeyer H, Chang C. Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes. Diabetes 1982, 31: 145-148. PMID: 6759230, DOI: 10.2337/diab.31.2.145.Peer-Reviewed Original Research
1980
Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation
F. J, Amatruda J. Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation. Science 1980, 210: 1029-1031. PMID: 7001632, DOI: 10.1126/science.7001632.Peer-Reviewed Original ResearchConceptsInsulin receptorComplex biological responseInteraction of insulinPresence of insulinEffect of insulinBinding sitesBiological responsesSpecific binding sitesRegulationPostreceptor eventsPrimary culturesTarget cellsRat hepatocytesReceptorsNormal numbersCellsInsulin-like activityHepatocytesInsulinInteractionInsulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin responseHysteretic properties of glucose uptake in rat adipocytes
Amatruda J. Hysteretic properties of glucose uptake in rat adipocytes. Life Sciences 1980, 26: 2289-2292. PMID: 6995769, DOI: 10.1016/0024-3205(80)90215-5.Peer-Reviewed Original Research
1978
Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity
Moxley R, Lockwood D, Amatruda J, Tobin J, Pozefsky T. Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity. Diabetes 1978, 27: 78-84. PMID: 624443, DOI: 10.2337/diab.27.2.78.Peer-Reviewed Original ResearchConceptsJejunoileal bypass surgeryInsulin responseAmino acid elevationMorbid obesityBypass surgeryIntravenous amino acidsAmino acid ingestionBasal insulin concentrationsAmino acid loadPortion of jejunumAcid tolerance testIntravenous loadAcid ingestionPreoperative valuesTolerance testInsulin concentrationsInsulin secretionAmino acid loadingInsulin releasePeak insulinPercentage increasePeak incrementAcid loadSurgeryObesity
1975
Insulin Receptor: Role in the Resistance of Human Obesity to Insulin
Amatruda J, Livingston J, Lockwood D. Insulin Receptor: Role in the Resistance of Human Obesity to Insulin. Science 1975, 188: 264-266. PMID: 164059, DOI: 10.1126/science.164059.Peer-Reviewed Original Research
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