1995
The effects of weight reduction to ideal body weight on body fat distribution
Hendler R, Welle S, Statt M, Barnard R, Amatruda J. The effects of weight reduction to ideal body weight on body fat distribution. Metabolism 1995, 44: 1413-1416. PMID: 7476327, DOI: 10.1016/0026-0495(95)90139-6.Peer-Reviewed Original ResearchConceptsIdeal body weightSubcutaneous fat areaBody mass indexFat areaObese womenFat distributionObese subjectsBody fatBody weightUpper body fat distributionIntraabdominal fat areaObese control subjectsBody fat distributionPercent body fatHealth risk factorsWeight reductionObese groupMass indexHip ratioControl subjectsRisk factorsMetabolic disordersControl groupWeight lossObese
1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1989
Insulin and steatonecrosis: Are they related?
Amatruda J, Salhanick A. Insulin and steatonecrosis: Are they related? Hepatology 1989, 10: 1024-1025. PMID: 2684837, DOI: 10.1002/hep.1840100627.Peer-Reviewed Original ResearchConceptsFree fatty acidsIntraperitoneal insulinInsulin secretionAdipose tissueType II diabetes mellitusMarked weight lossPeritoneal dialysis patientsSetting of obesityNon-alcoholic individualsPathogenesis of steatosisConcentrations of insulinType II diabetesJejunoileal bypassObese patientsRenal failureDiabetes mellitusDialysis patientsCAPD patientsHepatic histologyPresence of insulinFFA mobilizationHepatic steatosisIntraperitoneal administrationPortal veinInsulin concentrations
1988
The Accuracy of Blood Glucose Testing by Children
Strumph P, Odoroff C, Amatruda J. The Accuracy of Blood Glucose Testing by Children. Clinical Pediatrics 1988, 27: 188-194. PMID: 3349727, DOI: 10.1177/000992288802700403.Peer-Reviewed Original Research
1985
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
Amatruda J, Livingston J, Lockwood D. Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure. Diabetes/Metabolism Research And Reviews 1985, 1: 293-317. PMID: 3915256, DOI: 10.1002/dmr.5610010304.Peer-Reviewed Original Research
1984
Treatment of Insulin Reactions in Diabetics
Brodows R, Williams C, Amatruda J. Treatment of Insulin Reactions in Diabetics. JAMA 1984, 252: 3378-3381. PMID: 6389915, DOI: 10.1001/jama.1984.03350240024032.Peer-Reviewed Original ResearchConceptsGlycemic responsePlasma free insulin concentrationInsulin-dependent diabeticsFree insulin concentrationsMicroU/mLGlucose clamp techniquePlasma glucose levelsRebound hyperglycemiaSevere hypoglycemiaOutpatient settingSpontaneous episodesInsulin concentrationsInsulin reactionGlucose levelsClamp techniqueHypoglycemiaIngested carbohydrateD-glucoseDiabeticsOrange juiceTreatmentImportant determinantCommon sourceHyperglycemiaPatientsParathyroid hyperplasia and carcinoma within one gland
Desch C, Arsensis G, Woolf P, May A, Amatruda J. Parathyroid hyperplasia and carcinoma within one gland. The American Journal Of Medicine 1984, 77: 131-134. PMID: 6741974, DOI: 10.1016/0002-9343(84)90447-9.Peer-Reviewed Original ResearchConceptsOne-week historyParathyroid hormone levelsSerum calcium levelsThin fibrous bandNormal parathyroid glandsNormal parathyroid tissueAbdominal painSevere vomitingSurgical explorationParathyroid hyperplasiaParathyroid carcinomaParathyroid tissueNormal calciumParathyroid glandsRare associationHormone levelsFibrous bandsCalcium levelsCarcinomaScottish womenGlandVomitingPainPatientsHyperplasiaHepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
Lockwood D, Amatruda J. Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus. The American Journal Of Medicine 1983, 75: 23-31. PMID: 6369965, DOI: 10.1016/0002-9343(83)90250-4.Peer-Reviewed Original ResearchConceptsType II diabetes mellitusInsulin resistanceDiabetes mellitusRelative insulin deficiencyBlood sugar levelsInsulin-resistant statesInsulin deficiencyMetabolic controlResistant stateMellitusSugar levelsCellular alterationsEfficacious methodRecent evidenceObesityPathophysiologyAlterationsNumerous studiesFuture effortsClear understandingProminent featureVigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion
Amatruda J, Biddle T, Patton M, Lockwood D. Vigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion. The American Journal Of Medicine 1983, 74: 1016-1022. PMID: 6859052, DOI: 10.1016/0002-9343(83)90804-5.Peer-Reviewed Original ResearchConceptsCardiac arrhythmiasLiquid protein dietWeight maintenance dietIdeal body weightLife-threatening cardiac arrhythmiasExperimental dietsHypocaloric dietMetabolic wardCardiac changesEssential fatty acidsObese femalesElectrocardiographic recordingsCardiac rhythmBody weightVigorous supplementationArrhythmiasMaintenance dietProtein dietDaily allowanceDietHypocaloricEight-day periodSubjectsFatty acidsSignificant changesEffects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin
Kelleher P, Phinney S, Sims E, Bogardus C, Horton E, Bistrian B, Amatruda J, Lockwood D. Effects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin. Metabolism 1983, 32: 95-101. PMID: 6401350, DOI: 10.1016/0026-0495(83)90163-4.Peer-Reviewed Original ResearchConceptsCarbohydrate-restricted dietCarbohydrate-containing dietRetinol-binding proteinSerum concentrationsThyroxine-binding prealbuminGroup IGroup IISignificant decreaseObese individuals resultsNormal-weight subjectsGroup I subjectsNormal-weight individualsControl diet periodSerum albumin concentrationEffect of dietEucaloric dietObese subjectsIsocaloric substitutionWeight subjectsDiet periodVisceral proteinsWeight individualsTBPA concentrationsCaloric intakeAlbumin concentration
1981
Adverse effects of liquid protein fast on the handling of magnesium, calcium and phosphorus
Licata A, Lantigua R, Amatruda J, Lockwood D. Adverse effects of liquid protein fast on the handling of magnesium, calcium and phosphorus. The American Journal Of Medicine 1981, 71: 767-772. PMID: 7304647, DOI: 10.1016/0002-9343(81)90362-4.Peer-Reviewed Original ResearchConceptsUrinary lossMagnesium levelsUrinary titratable acid excretionFecal lossSerum bicarbonate levelsSerum calcium levelsTitratable acid excretionMeq of potassiumNegative mineral balanceSkeletal storesMetabolic wardUrinary calciumObese subjectsSerum phosphorusRenal lossUrinary ammoniumDietary intakeHandling of magnesiumExcretion of phosphorusMineral metabolismSerum valuesAcid excretionBicarbonate levelsCalcium levelsLiquid protein
1980
Cardiac Arrhythmias Associated with a Liquid Protein Diet for the Treatment of Obesity
Lantigua R, Amatruda J, Biddle T, Forbes G, Lockwood D. Cardiac Arrhythmias Associated with a Liquid Protein Diet for the Treatment of Obesity. New England Journal Of Medicine 1980, 303: 735-738. PMID: 7402271, DOI: 10.1056/nejm198009253031305.Peer-Reviewed Original Research
1979
Hypothalamic-Hypopituitarism due to Temporal Arteritis
Everett G, Amatruda J, Woolf P. Hypothalamic-Hypopituitarism due to Temporal Arteritis. JAMA Internal Medicine 1979, 139: 474-475. PMID: 435003, DOI: 10.1001/archinte.1979.03630410080023.Peer-Reviewed Original ResearchConceptsTemporal arteritisHypothalamic hypopituitarismThyroid-stimulating hormone levelsHypothalamic-pituitary regionAbundant blood supplyAdministration of chlorpromazineBasal gonadotrophinsGonadotrophin responseNormal prolactinHypothalamic originInsulin hypoglycemiaNeurological lesionsProlactin responseHormone levelsBlood supplyHypopituitarismPituitary glandGrowth hormoneApparent protectionArteritisProlactinAdministrationFurther evidenceProtirelinGonadotrophin
1978
Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity
Moxley R, Lockwood D, Amatruda J, Tobin J, Pozefsky T. Loss of Insulin Response to Ingested Amino Acids After Jejunoileal Bypass Surgery for Morbid Obesity. Diabetes 1978, 27: 78-84. PMID: 624443, DOI: 10.2337/diab.27.2.78.Peer-Reviewed Original ResearchConceptsJejunoileal bypass surgeryInsulin responseAmino acid elevationMorbid obesityBypass surgeryIntravenous amino acidsAmino acid ingestionBasal insulin concentrationsAmino acid loadPortion of jejunumAcid tolerance testIntravenous loadAcid ingestionPreoperative valuesTolerance testInsulin concentrationsInsulin secretionAmino acid loadingInsulin releasePeak insulinPercentage increasePeak incrementAcid loadSurgeryObesity
1975
Insulin Receptor: Role in the Resistance of Human Obesity to Insulin
Amatruda J, Livingston J, Lockwood D. Insulin Receptor: Role in the Resistance of Human Obesity to Insulin. Science 1975, 188: 264-266. PMID: 164059, DOI: 10.1126/science.164059.Peer-Reviewed Original Research
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