1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsApolipoproteins BCells, CulturedInsulinKineticsLeucineLipidsLiverMaleProtein BiosynthesisRatsRats, Inbred StrainsVanadatesConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibition
1986
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes
Sparks C, Sparks J, Bolognino M, Salhanick A, Strumph P, Amatruda J. Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes. Metabolism 1986, 35: 1128-1136. PMID: 3537632, DOI: 10.1016/0026-0495(86)90026-0.Peer-Reviewed Original ResearchConceptsLipoprotein synthesisPostprandial insulin releasePrimary culturesHepatic lipoprotein secretionEffect of insulinApo B secretionLipoprotein metabolic pathwaysAddition of insulinApo B massMonoclonal radioimmunoassayInsulin concentrationsVLDL secretionMedia insulin concentrationsB secretionApolipoprotein BInsulin releaseLipid secretionLipoprotein secretionDensity lipoproteinLipid radioactivityPhysiologic concentrationsRat hepatocytesLipoprotein apoproteinsInsulinInsulin effect
1985
The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products
Colbert R, Amatruda J, Young D. The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products. Biochimica Et Biophysica Acta 1985, 826: 49-66. PMID: 4041461, DOI: 10.1016/s0167-4781(85)80007-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDexamethasoneElectrophoresis, Polyacrylamide GelGenesKineticsLiverMaleMolecular WeightProteinsRatsRats, Inbred StrainsTranscription, GeneticConceptsGlucocorticoid domainProtein gene productLong-term hormone treatmentEffects of glucocorticoidsSteroid hormone responsesHormone-mediated changesHormone responseHormone treatmentGlucocorticoid inductionShort-term incubationSuch long-term changesNormal hepatocytesGlucocorticoidsHepatoma cellsSpontaneous changesInductionHormone inductionGene productsTranscriptional activityDexamethasoneLong-term changesProgressionProteinNormal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus
Amatruda J, Roncone A. Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus. Biochemical And Biophysical Research Communications 1985, 129: 163-170. PMID: 3890853, DOI: 10.1016/0006-291x(85)91417-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneDiabetes Mellitus, ExperimentalInsulinLiverMalePhosphorylationRatsRats, Inbred StrainsReceptor, InsulinConceptsHepatic insulin resistanceNonketotic diabetes mellitusInability of insulinDiabetes mellitusInsulin resistanceInsulin receptor autophosphorylationInsulin actionPutative mediatorsStreptozotocin-induced diabetes mellitusReceptor autophosphorylationDose-response relationshipInsulin receptor bindingAbility of insulinMembrane insulin receptorsDiabetic animalsInsulin treatmentInsulin dose-response relationshipInsulin bindingMellitusPlasma membrane insulin receptorsInsulinReceptor bindingInsulin receptor
1984
Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2Drug SynergismHumansInsulinInsulin ResistanceLipidsLiverProteinsRatsRats, Inbred StrainsTime FactorsTolazamideConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase
Amatruda J, Chang C. Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase. Biochemical And Biophysical Research Communications 1983, 112: 35-41. PMID: 6340685, DOI: 10.1016/0006-291x(83)91793-x.Peer-Reviewed Original ResearchConceptsInsulin resistanceLiver particulate fractionDiabetes mellitusRelease of mediatorsFailure of insulinEffect of insulinAbility of insulinDiabetic animalsInsulin treatmentControl animalsParticulate fractionPyruvate dehydrogenase activityInsulinLiverMellitusFastingDehydrogenase activityAnimalsPyruvate dehydrogenasePotentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats
Salhanick A, Konowitz P, Amatruda J. Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats. Diabetes 1983, 32: 206-212. PMID: 6337899, DOI: 10.2337/diab.32.3.206.Peer-Reviewed Original ResearchConceptsDiabetic ratsInsulin actionInsulin responsivenessPrimary culturesStreptozotocin-diabetic ratsHepatic insulin resistanceDose-dependent increaseInsulin-dependent actionInsulin-stimulated ratesDependent diabetesDiabetic animalsInsulin resistanceNondiabetic animalsInsulin sensitivityAbsence of insulinInsulin secretionSignificant potentiationNormal ratsChronic exposureSpecific insulinRatsSerum-free mediumInsulinSulfonylurea tolazamideSulfonylureasThe regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats
Amatruda J, Chang C. The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats. Metabolism 1983, 32: 224-229. PMID: 6402645, DOI: 10.1016/0026-0495(83)90186-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDiabetes Mellitus, ExperimentalDiabetic KetoacidosisFastingInsulin ResistanceLipidsLiverMaleRatsRats, Inbred StrainsConceptsDiabetic ratsDiabetic animalsInsulin responsivenessChronic exposurePrimary culturesAcute effectsBasal lipogenesisStreptozotocin-diabetic ratsStreptozotocin-diabetic animalsLipid synthesisNormal control animalsPresence of insulinInsulin resistanceLipogenic responseInsulin administrationNormal ratsControl animalsNormal controlsNormal animalsRatsFasted ratsInsulinAcute responsivenessLipogenesisM insulin
1982
Glucocorticoid-induced Insulin Resistance
F. J, Amatruda J. Glucocorticoid-induced Insulin Resistance. Journal Of Clinical Investigation 1982, 69: 866-875. PMID: 7042756, PMCID: PMC370141, DOI: 10.1172/jci110526.Peer-Reviewed Original ResearchConceptsAbility of insulinControl animalsInsulin bindingInsulin degradationDexamethasone treatmentNormal ratsInsulin receptorInsulin actionAminoisobutyrate uptakeWeight-matched control animalsGlucocorticoid-induced insulin resistancePrimary culturesAdministration of dexamethasoneDexamethasone-treated animalsPresence of hyperinsulinemiaEffect of insulinCellular insulin receptorsDose-response curveHepatocyte insulin receptorsSignificant hyperinsulinemiaInsulin resistanceAbsence of dexamethasoneLess insulinInsulin concentrationsVivo hyperinsulinemiaInsulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes
Amatruda J, Newmeyer H, Chang C. Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes. Diabetes 1982, 31: 145-148. PMID: 6759230, DOI: 10.2337/diab.31.2.145.Peer-Reviewed Original Research
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