1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1985
The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products
Colbert R, Amatruda J, Young D. The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products. Biochimica Et Biophysica Acta 1985, 826: 49-66. PMID: 4041461, DOI: 10.1016/s0167-4781(85)80007-5.Peer-Reviewed Original ResearchConceptsGlucocorticoid domainProtein gene productLong-term hormone treatmentEffects of glucocorticoidsSteroid hormone responsesHormone-mediated changesHormone responseHormone treatmentGlucocorticoid inductionShort-term incubationSuch long-term changesNormal hepatocytesGlucocorticoidsHepatoma cellsSpontaneous changesInductionHormone inductionGene productsTranscriptional activityDexamethasoneLong-term changesProgressionProtein
1984
Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
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