1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1989
Insulin and steatonecrosis: Are they related?
Amatruda J, Salhanick A. Insulin and steatonecrosis: Are they related? Hepatology 1989, 10: 1024-1025. PMID: 2684837, DOI: 10.1002/hep.1840100627.Peer-Reviewed Original ResearchConceptsFree fatty acidsIntraperitoneal insulinInsulin secretionAdipose tissueType II diabetes mellitusMarked weight lossPeritoneal dialysis patientsSetting of obesityNon-alcoholic individualsPathogenesis of steatosisConcentrations of insulinType II diabetesJejunoileal bypassObese patientsRenal failureDiabetes mellitusDialysis patientsCAPD patientsHepatic histologyPresence of insulinFFA mobilizationHepatic steatosisIntraperitoneal administrationPortal veinInsulin concentrations
1983
The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats
Amatruda J, Chang C. The regulation of lipid synthesis in primary cultures of hepatocytes from nonketotic streptozotocin diabetic rats. Metabolism 1983, 32: 224-229. PMID: 6402645, DOI: 10.1016/0026-0495(83)90186-5.Peer-Reviewed Original ResearchConceptsDiabetic ratsDiabetic animalsInsulin responsivenessChronic exposurePrimary culturesAcute effectsBasal lipogenesisStreptozotocin-diabetic ratsStreptozotocin-diabetic animalsLipid synthesisNormal control animalsPresence of insulinInsulin resistanceLipogenic responseInsulin administrationNormal ratsControl animalsNormal controlsNormal animalsRatsFasted ratsInsulinAcute responsivenessLipogenesisM insulin
1982
Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes
Amatruda J, Newmeyer H, Chang C. Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes. Diabetes 1982, 31: 145-148. PMID: 6759230, DOI: 10.2337/diab.31.2.145.Peer-Reviewed Original Research
1980
Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation
F. J, Amatruda J. Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation. Science 1980, 210: 1029-1031. PMID: 7001632, DOI: 10.1126/science.7001632.Peer-Reviewed Original ResearchConceptsInsulin receptorComplex biological responseInteraction of insulinPresence of insulinEffect of insulinBinding sitesBiological responsesSpecific binding sitesRegulationPostreceptor eventsPrimary culturesTarget cellsRat hepatocytesReceptorsNormal numbersCellsInsulin-like activityHepatocytesInsulinInteraction
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