1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibition
1980
Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation
F. J, Amatruda J. Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation. Science 1980, 210: 1029-1031. PMID: 7001632, DOI: 10.1126/science.7001632.Peer-Reviewed Original ResearchConceptsInsulin receptorComplex biological responseInteraction of insulinPresence of insulinEffect of insulinBinding sitesBiological responsesSpecific binding sitesRegulationPostreceptor eventsPrimary culturesTarget cellsRat hepatocytesReceptorsNormal numbersCellsInsulin-like activityHepatocytesInsulinInteraction
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