1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibition
1986
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes
Sparks C, Sparks J, Bolognino M, Salhanick A, Strumph P, Amatruda J. Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes. Metabolism 1986, 35: 1128-1136. PMID: 3537632, DOI: 10.1016/0026-0495(86)90026-0.Peer-Reviewed Original ResearchConceptsLipoprotein synthesisPostprandial insulin releasePrimary culturesHepatic lipoprotein secretionEffect of insulinApo B secretionLipoprotein metabolic pathwaysAddition of insulinApo B massMonoclonal radioimmunoassayInsulin concentrationsVLDL secretionMedia insulin concentrationsB secretionApolipoprotein BInsulin releaseLipid secretionLipoprotein secretionDensity lipoproteinLipid radioactivityPhysiologic concentrationsRat hepatocytesLipoprotein apoproteinsInsulinInsulin effect
1984
Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase
Amatruda J, Chang C. Insulin resistance in the liver in fasting and diabetes mellitus: The failure of insulin to stimulate the release of a chemical modulator of pyruvate dehydrogenase. Biochemical And Biophysical Research Communications 1983, 112: 35-41. PMID: 6340685, DOI: 10.1016/0006-291x(83)91793-x.Peer-Reviewed Original ResearchConceptsInsulin resistanceLiver particulate fractionDiabetes mellitusRelease of mediatorsFailure of insulinEffect of insulinAbility of insulinDiabetic animalsInsulin treatmentControl animalsParticulate fractionPyruvate dehydrogenase activityInsulinLiverMellitusFastingDehydrogenase activityAnimalsPyruvate dehydrogenase
1982
Glucocorticoid-induced Insulin Resistance
F. J, Amatruda J. Glucocorticoid-induced Insulin Resistance. Journal Of Clinical Investigation 1982, 69: 866-875. PMID: 7042756, PMCID: PMC370141, DOI: 10.1172/jci110526.Peer-Reviewed Original ResearchConceptsAbility of insulinControl animalsInsulin bindingInsulin degradationDexamethasone treatmentNormal ratsInsulin receptorInsulin actionAminoisobutyrate uptakeWeight-matched control animalsGlucocorticoid-induced insulin resistancePrimary culturesAdministration of dexamethasoneDexamethasone-treated animalsPresence of hyperinsulinemiaEffect of insulinCellular insulin receptorsDose-response curveHepatocyte insulin receptorsSignificant hyperinsulinemiaInsulin resistanceAbsence of dexamethasoneLess insulinInsulin concentrationsVivo hyperinsulinemia
1980
Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation
F. J, Amatruda J. Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation. Science 1980, 210: 1029-1031. PMID: 7001632, DOI: 10.1126/science.7001632.Peer-Reviewed Original ResearchConceptsInsulin receptorComplex biological responseInteraction of insulinPresence of insulinEffect of insulinBinding sitesBiological responsesSpecific binding sitesRegulationPostreceptor eventsPrimary culturesTarget cellsRat hepatocytesReceptorsNormal numbersCellsInsulin-like activityHepatocytesInsulinInteraction
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