1989
Insulin and steatonecrosis: Are they related?
Amatruda J, Salhanick A. Insulin and steatonecrosis: Are they related? Hepatology 1989, 10: 1024-1025. PMID: 2684837, DOI: 10.1002/hep.1840100627.Peer-Reviewed Original ResearchConceptsFree fatty acidsIntraperitoneal insulinInsulin secretionAdipose tissueType II diabetes mellitusMarked weight lossPeritoneal dialysis patientsSetting of obesityNon-alcoholic individualsPathogenesis of steatosisConcentrations of insulinType II diabetesJejunoileal bypassObese patientsRenal failureDiabetes mellitusDialysis patientsCAPD patientsHepatic histologyPresence of insulinFFA mobilizationHepatic steatosisIntraperitoneal administrationPortal veinInsulin concentrations
1980
Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin response
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