2008
A TWO-YEAR STUDY TO ASSESS THE EFFICACY, SAFETY, AND TOLERABILITY OF TARANABANT IN OBESE PATIENTS: 52 WEEK RESULTS
Carr R, Gantz I, Erondu N, Moreno M, Suryawanshi S, Musser B, Nayee J, Johnson-Levonas A, Heymsfield S, Amatruda J. A TWO-YEAR STUDY TO ASSESS THE EFFICACY, SAFETY, AND TOLERABILITY OF TARANABANT IN OBESE PATIENTS: 52 WEEK RESULTS. Atherosclerosis Plus 2008, 9: 12. DOI: 10.1016/s1567-5688(08)70044-8.Peer-Reviewed Original ResearchEFFECTS OF TARANABANT, A NOVEL CANNABINOID 1 RECEPTOR (CB-1R) INVERSE AGONIST, ON WEIGHT REDUCTION IN OBESE PATIENTS OVER 12 WEEKS
Carr R, Erondu N, Gonzalez C, Gumbiner B, Musser B, Lu K, Capece R, Klein S, Ravussin E, Amatruda J, Heymsfield S. EFFECTS OF TARANABANT, A NOVEL CANNABINOID 1 RECEPTOR (CB-1R) INVERSE AGONIST, ON WEIGHT REDUCTION IN OBESE PATIENTS OVER 12 WEEKS. Atherosclerosis Plus 2008, 9: 209. DOI: 10.1016/s1567-5688(08)70835-3.Peer-Reviewed Original Research
1996
New Approaches for the Treatment of Diabetes Mellitus
Amatruda J, McCaleb M. New Approaches for the Treatment of Diabetes Mellitus. Handbook Of Experimental Pharmacology 1996, 119: 697-713. DOI: 10.1007/978-3-662-09127-2_24.Peer-Reviewed Original ResearchInsulin-dependent diabetes mellitusImpaired glucose toleranceDiabetes mellitusGlucose toleranceIncidence of neuropathyIncidence of retinopathyDependent diabetes mellitusMajor etiologic factorPrevention of deteriorationCardiovascular mortalityEtiologic factorsVascular diseaseRisk factorsCardiovascular diseaseEpidemiologic dataNIDDMMellitusMajor causeRecent dataDiseaseIncidencePreventionNeuropathyMorbidityRetinopathy
1995
The effects of weight reduction to ideal body weight on body fat distribution
Hendler R, Welle S, Statt M, Barnard R, Amatruda J. The effects of weight reduction to ideal body weight on body fat distribution. Metabolism 1995, 44: 1413-1416. PMID: 7476327, DOI: 10.1016/0026-0495(95)90139-6.Peer-Reviewed Original ResearchConceptsIdeal body weightSubcutaneous fat areaBody mass indexFat areaObese womenFat distributionObese subjectsBody fatBody weightUpper body fat distributionIntraabdominal fat areaObese control subjectsBody fat distributionPercent body fatHealth risk factorsWeight reductionObese groupMass indexHip ratioControl subjectsRisk factorsMetabolic disordersControl groupWeight lossObese
1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism 1994, 43: 441-445. PMID: 8159100, DOI: 10.1016/0026-0495(94)90073-6.Peer-Reviewed Original ResearchConceptsReduced-obese subjectsObese womenLeucine RaInsulin resistanceControl groupNormal weight control groupReduced-obese groupNormal-weight womenNormal-weight subjectsGlucose disposal rateWhole-body proteolysisLean body massWhole body rateObese groupNormal weightHip ratioGlucose disposalDisposal rateIdeal weightObeseInsulinWeight lossWomenDifferential effectsBody mass
1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
1989
Insulin and steatonecrosis: Are they related?
Amatruda J, Salhanick A. Insulin and steatonecrosis: Are they related? Hepatology 1989, 10: 1024-1025. PMID: 2684837, DOI: 10.1002/hep.1840100627.Peer-Reviewed Original ResearchConceptsFree fatty acidsIntraperitoneal insulinInsulin secretionAdipose tissueType II diabetes mellitusMarked weight lossPeritoneal dialysis patientsSetting of obesityNon-alcoholic individualsPathogenesis of steatosisConcentrations of insulinType II diabetesJejunoileal bypassObese patientsRenal failureDiabetes mellitusDialysis patientsCAPD patientsHepatic histologyPresence of insulinFFA mobilizationHepatic steatosisIntraperitoneal administrationPortal veinInsulin concentrations
1988
Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-Mimetic Effects of Vanadate in Primary Cultures of Rat Hepatocytes. Diabetes 1988, 37: 1234-1240. PMID: 3044889, DOI: 10.2337/diab.37.9.1234.Peer-Reviewed Original ResearchConceptsApoB secretionIntracellular lipogenesisHepatic apolipoprotein B secretionPrimary culturesApolipoprotein B secretionTermination of actionEffect of insulinMedium accumulationInsulin-mimetic effectsB secretionEffect of vanadatePostreceptor levelInsulin actionRat hepatocytesInsulinIntracellular glycogen accumulationHepatic proteinsSecretionInsulin-mimetic agentsGlycogen accumulationMimics insulin actionApoB.LipogenesisHepatocytesInhibitionInsulin-mimetic effects of vanadate in primary cultures of rat hepatocytes
Jackson T, Salhanick A, Sparks J, Sparks C, Bolognino M, Amatruda J. Insulin-mimetic effects of vanadate in primary cultures of rat hepatocytes. Diabetes 1988, 37: 1234-1240. DOI: 10.2337/diabetes.37.9.1234.Peer-Reviewed Original ResearchThe Accuracy of Blood Glucose Testing by Children
Strumph P, Odoroff C, Amatruda J. The Accuracy of Blood Glucose Testing by Children. Clinical Pediatrics 1988, 27: 188-194. PMID: 3349727, DOI: 10.1177/000992288802700403.Peer-Reviewed Original Research
1986
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes
Sparks C, Sparks J, Bolognino M, Salhanick A, Strumph P, Amatruda J. Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes. Metabolism 1986, 35: 1128-1136. PMID: 3537632, DOI: 10.1016/0026-0495(86)90026-0.Peer-Reviewed Original ResearchConceptsLipoprotein synthesisPostprandial insulin releasePrimary culturesHepatic lipoprotein secretionEffect of insulinApo B secretionLipoprotein metabolic pathwaysAddition of insulinApo B massMonoclonal radioimmunoassayInsulin concentrationsVLDL secretionMedia insulin concentrationsB secretionApolipoprotein BInsulin releaseLipid secretionLipoprotein secretionDensity lipoproteinLipid radioactivityPhysiologic concentrationsRat hepatocytesLipoprotein apoproteinsInsulinInsulin effectEvidence for abnormal cholinergic neuromuscular transmission in diabetic rat small intestine
Nowak T, Harrington B, Kalbfleisch J, Amatruda J. Evidence for abnormal cholinergic neuromuscular transmission in diabetic rat small intestine. Gastroenterology 1986, 91: 124-132. PMID: 3011579, DOI: 10.1016/0016-5085(86)90448-8.Peer-Reviewed Original ResearchConceptsAtropine-resistant contractionsCholinergic neuromuscular transmissionField stimulationRat small intestineSmall intestineNeuromuscular transmissionKrebs solutionDistal rat small intestineStreptozotocin-induced diabetes mellitusInsulin-treated diabetic ratsOral-caudal axisHigh-amplitude contractionsAtropine-sensitive contractionsInsulin-treated diabeticsElectrical field stimulationDistal small intestineSignificant differencesInsulin therapyNeural blockadeDiabetes mellitusDiabetic ratsM atropineMyenteric plexusContraction amplitudeAmplitude contractions
1985
The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products
Colbert R, Amatruda J, Young D. The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products. Biochimica Et Biophysica Acta 1985, 826: 49-66. PMID: 4041461, DOI: 10.1016/s0167-4781(85)80007-5.Peer-Reviewed Original ResearchConceptsGlucocorticoid domainProtein gene productLong-term hormone treatmentEffects of glucocorticoidsSteroid hormone responsesHormone-mediated changesHormone responseHormone treatmentGlucocorticoid inductionShort-term incubationSuch long-term changesNormal hepatocytesGlucocorticoidsHepatoma cellsSpontaneous changesInductionHormone inductionGene productsTranscriptional activityDexamethasoneLong-term changesProgressionProteinIngested Carbohydrates and Blood Glucose in Diabetics-Reply
Amatruda J, Brodows R. Ingested Carbohydrates and Blood Glucose in Diabetics-Reply. JAMA 1985, 254: 235-235. DOI: 10.1001/jama.1985.03360020064024.Peer-Reviewed Original ResearchNormal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus
Amatruda J, Roncone A. Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus. Biochemical And Biophysical Research Communications 1985, 129: 163-170. PMID: 3890853, DOI: 10.1016/0006-291x(85)91417-2.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceNonketotic diabetes mellitusInability of insulinDiabetes mellitusInsulin resistanceInsulin receptor autophosphorylationInsulin actionPutative mediatorsStreptozotocin-induced diabetes mellitusReceptor autophosphorylationDose-response relationshipInsulin receptor bindingAbility of insulinMembrane insulin receptorsDiabetic animalsInsulin treatmentInsulin dose-response relationshipInsulin bindingMellitusPlasma membrane insulin receptorsInsulinReceptor bindingInsulin receptorCellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
Amatruda J, Livingston J, Lockwood D. Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure. Diabetes/Metabolism Research And Reviews 1985, 1: 293-317. PMID: 3915256, DOI: 10.1002/dmr.5610010304.Peer-Reviewed Original Research
1984
Treatment of Insulin Reactions in Diabetics
Brodows R, Williams C, Amatruda J. Treatment of Insulin Reactions in Diabetics. JAMA 1984, 252: 3378-3381. PMID: 6389915, DOI: 10.1001/jama.1984.03350240024032.Peer-Reviewed Original ResearchConceptsGlycemic responsePlasma free insulin concentrationInsulin-dependent diabeticsFree insulin concentrationsMicroU/mLGlucose clamp techniquePlasma glucose levelsRebound hyperglycemiaSevere hypoglycemiaOutpatient settingSpontaneous episodesInsulin concentrationsInsulin reactionGlucose levelsClamp techniqueHypoglycemiaIngested carbohydrateD-glucoseDiabeticsOrange juiceTreatmentImportant determinantCommon sourceHyperglycemiaPatientsParathyroid hyperplasia and carcinoma within one gland
Desch C, Arsensis G, Woolf P, May A, Amatruda J. Parathyroid hyperplasia and carcinoma within one gland. The American Journal Of Medicine 1984, 77: 131-134. PMID: 6741974, DOI: 10.1016/0002-9343(84)90447-9.Peer-Reviewed Original ResearchConceptsOne-week historyParathyroid hormone levelsSerum calcium levelsThin fibrous bandNormal parathyroid glandsNormal parathyroid tissueAbdominal painSevere vomitingSurgical explorationParathyroid hyperplasiaParathyroid carcinomaParathyroid tissueNormal calciumParathyroid glandsRare associationHormone levelsFibrous bandsCalcium levelsCarcinomaScottish womenGlandVomitingPainPatientsHyperplasiaHepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action.
Amatruda J, Salhanick A, Chang C. Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 1984, 7 Suppl 1: 47-53. PMID: 6376029.Peer-Reviewed Original ResearchConceptsLiver particulate fractionInsulin resistanceDiabetes mellitusInsulin actionHepatic insulin responsivenessPrimary culturesDependent diabetes mellitusRelease of mediatorsSerum glucose levelsStreptozotocin-diabetic animalsHepatic insulin resistanceEffect of insulinAbility of insulinDiabetic animalsDiabetic stateSerum glucoseInsulin treatmentGlucose levelsVivo treatmentControl animalsHepatic lipogenesisParticulate fractionInsulin responsivenessMellitusInsulin binding
1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
Lockwood D, Amatruda J. Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus. The American Journal Of Medicine 1983, 75: 23-31. PMID: 6369965, DOI: 10.1016/0002-9343(83)90250-4.Peer-Reviewed Original ResearchConceptsType II diabetes mellitusInsulin resistanceDiabetes mellitusRelative insulin deficiencyBlood sugar levelsInsulin-resistant statesInsulin deficiencyMetabolic controlResistant stateMellitusSugar levelsCellular alterationsEfficacious methodRecent evidenceObesityPathophysiologyAlterationsNumerous studiesFuture effortsClear understandingProminent feature
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