2021
Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies
De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid use disorderExperimental pain studiesAbuse potentialRespiratory depressionAcute painPain studiesUse disordersSystematic reviewGreater abuse potentialHigh-potency opioidsMethadone-maintained personsSignificant pain reliefRespiratory depressant effectsHigh-potency compoundsOpioid naïveAgonist therapyOpioid dosesPain reliefAnalgesic effectSevere painDepressant effectAdditional dosesStudy qualityHealthy persons
2020
Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development
De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.Peer-Reviewed Original ResearchConceptsOpioid use disorderClinical trialsPresence of OUDSystematic reviewTreatment of OUDActive treatment groupNeurobiology of painDrug developmentSpontaneous painAntihyperalgesic effectOngoing painPharmacological managementAnalgesic effectClinical featuresCochrane DatabasePharmacological treatmentEligible studiesOpioid addictionPainTreatment groupsUse disordersAbuse liabilityNovel therapeuticsNonsignificant heterogeneityNeurobiological overlap
2025
Response to the letter to the editor
Hickey T, Avila-Quintero V, De Aquino J. Response to the letter to the editor. Regional Anesthesia & Pain Medicine 2025, rapm-2025-106481. PMID: 39929637, DOI: 10.1136/rapm-2025-106481.Peer-Reviewed Original ResearchBuprenorphine versus full agonist opioids for acute postoperative pain management: an infographic
Hickey T, Costa G, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: an infographic. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106304. PMID: 39793993, DOI: 10.1136/rapm-2024-106304.Peer-Reviewed Original ResearchBuprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106014. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.Peer-Reviewed Original ResearchAcute postoperative pain managementPostoperative pain managementAcute postoperative painDuration of analgesiaPain intensityPain managementRandomized controlled trialsRisk of biasAgonist opioidsPostoperative painControlled trialsRescue analgesiaMeta-analysis of randomized controlled trialsMean duration of analgesiaRescue analgesia useLong duration of actionCochrane Central Register of Controlled TrialsSafety of buprenorphineCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsRandom-effects meta-analysisAdverse effectsDuration of actionCochrane Central Register
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