Featured Publications
Glial modulators as novel therapeutics for comorbid pain and opioid use disorder
Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.Peer-Reviewed Original ResearchOpioid use disorderChronic painGlial modulationNovel treatment approachesComorbid painPublic health problemTreatment approachesImproved pain measuresLiterature search of PubMedIncreased opioid prescriptionsSearch of PubMedAddiction-related outcomesSignificant public health problemComorbid disordersOpioid prescriptionsGoogle Scholar databasesPain measuresHealth problemsPain managementClinical studiesTreatment challengesClinical trialsPatient populationPainGlial activation
2025
Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106014. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.Peer-Reviewed Original ResearchAcute postoperative pain managementPostoperative pain managementAcute postoperative painDuration of analgesiaPain intensityPain managementRandomized controlled trialsRisk of biasAgonist opioidsPostoperative painControlled trialsRescue analgesiaMeta-analysis of randomized controlled trialsMean duration of analgesiaRescue analgesia useLong duration of actionCochrane Central Register of Controlled TrialsSafety of buprenorphineCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsRandom-effects meta-analysisAdverse effectsDuration of actionCochrane Central Register
2024
Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes
Nunes J, Jegede O, De Aquino J. Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes. The American Journal Of Drug And Alcohol Abuse 2024, 50: 455-461. PMID: 39018662, DOI: 10.1080/00952990.2024.2369866.Peer-Reviewed Original ResearchOpioid use disorderUse disorderRacism-related stressChronic pain outcomesOpioid overdose mortality ratesOverdose mortality ratesHealthcare disparitiesBiopsychosocial burdenPain outcomesPrescribed opioidsUndertreated painChronic painPain managementOpioid mortalityPerpetuate stigmaTreat painPain experienceOpioidPainRisk factorsMinoritized populationsMinoritized peopleMortality rateDisparitiesAddiction treatment
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