2019
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association
Xu J, Gaddis N, Bartz T, Hou R, Manichaikul A, Pankratz N, Smith A, Sun F, Terzikhan N, Markunas C, Patchen B, Schu M, Beydoun M, Brusselle G, Eiriksdottir G, Zhou X, Wood A, Graff M, Harris T, Ikram M, Jacobs D, Launer L, Lemaitre R, O’Connor G, Oelsner E, Psaty B, Vasan R, Rohde R, Rich S, Rotter J, Seshadri S, Smith L, Tiemeier H, Tsai M, Uitterlinden A, Voruganti V, Xu H, Zilhão N, Fornage M, Zillikens M, London S, Barr R, Dupuis J, Gharib S, Gudnason V, Lahousse L, North K, Steffen L, Cassano P, Hancock D. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 631-642. PMID: 30199657, PMCID: PMC6396866, DOI: 10.1164/rccm.201802-0304oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Physiological PhenomenaSex FactorsSmokingVital CapacityConceptsSNP associationsGenome-wide interaction analysisHeart and Aging ResearchMeta-analysesCohort-specific resultsAssociated with lower FVCGenome-wide analysisGenomic Epidemiology ConsortiumAssociated with FEV<sub>1</sub> anPulmonary function testsEpidemiology ConsortiumFatty acidsEffect modificationFunctional associationN-3 PUFAPulmonary healthLower FVCGenetic susceptibilitySpirometric measurementsCohortPolyunsaturated fatty acidsAssociationMeasures of pulmonary function testsInteraction analysisFVC
2017
Meta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function
Xu J, Bartz T, Eiriksdottir G, Frazier‐Wood A, Gudnason V, Lahousse L, Manichaikul A, Rohde R, Sun F, Terzikhan N, Zhou X, Barr R, Brusselle G, Dupuis J, Gharib S, London S, North K, Psaty B, Smith A, Steffen L, Hancock D, Cassano P. Meta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.167.5.Peer-Reviewed Original ResearchHigher forced vital capacityEA groupSmoking statusForced vital capacityNo significant associationMeta-analysisHeart and Aging ResearchEuropean ancestryAncestry groupsCohort-specific resultsFEV 1Genomic Epidemiology ConsortiumYears of cigarette smokingPopulation-based studyPlasma docosahexaenoic acidAfrican ancestryPulmonary function testsPulmonary functionEpidemiology ConsortiumEffect modificationNever smokersLinear regression modelsPack-yearsFEV 1 /FVCEffect estimates