Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19)
Patchen B, Xu J, Barr R, van Eekelen E, Dupuis J, North K, Gharib S, Lahousse L, Lemaitre R, Manichaikul A, de Mutsert R, Houston D, Saccone N, Steffen L, Terzikhan N, Xu H, Wojczynski M, Hancock D, Cassano P. Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19). Current Developments In Nutrition 2019, 3: nzz039.p18-087-19. PMCID: PMC6579416, DOI: 10.1093/cdn/nzz039.p18-087-19.Peer-Reviewed Original ResearchForced vital capacityN-3 PUFAFormer smokersLung functionHeart and Aging ResearchMeta-analysisAlpha-linolenic acidDietary intakeFish intakeGenomic Epidemiology ConsortiumFixed-effect meta-analysisPositive associationAssociated with forced expiratory volumeAssociated with higher lung functionHigher forced vital capacityDocosahexaenoic acidSD higher intakeAssociated with FEV1Higher lung functionDocosapentaenoic acidEicosapentanoic acidMarine n-3 PUFADietary n-3 PUFASmoking status interactionAssociation of docosahexaenoic acidOmega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association
Xu J, Gaddis N, Bartz T, Hou R, Manichaikul A, Pankratz N, Smith A, Sun F, Terzikhan N, Markunas C, Patchen B, Schu M, Beydoun M, Brusselle G, Eiriksdottir G, Zhou X, Wood A, Graff M, Harris T, Ikram M, Jacobs D, Launer L, Lemaitre R, O’Connor G, Oelsner E, Psaty B, Vasan R, Rohde R, Rich S, Rotter J, Seshadri S, Smith L, Tiemeier H, Tsai M, Uitterlinden A, Voruganti V, Xu H, Zilhão N, Fornage M, Zillikens M, London S, Barr R, Dupuis J, Gharib S, Gudnason V, Lahousse L, North K, Steffen L, Cassano P, Hancock D. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 631-642. PMID: 30199657, PMCID: PMC6396866, DOI: 10.1164/rccm.201802-0304oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Physiological PhenomenaSex FactorsSmokingVital CapacityConceptsSNP associationsGenome-wide interaction analysisHeart and Aging ResearchMeta-analysesCohort-specific resultsAssociated with lower FVCGenome-wide analysisGenomic Epidemiology ConsortiumAssociated with FEV<sub>1</sub> anPulmonary function testsEpidemiology ConsortiumFatty acidsEffect modificationFunctional associationN-3 PUFAPulmonary healthLower FVCGenetic susceptibilitySpirometric measurementsCohortPolyunsaturated fatty acidsAssociationMeasures of pulmonary function testsInteraction analysisFVC