2025
Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI
Park D, Mahajan S, Fishman E, Ambrosini A, Acero L, Hu J, Campbell G, Babapour G, Kelsey M, Douglas P, Gupta A, Frampton J, Nanna M. Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI. JACC Advances 2025, 4: 101543. PMID: 39886301, PMCID: PMC11780104, DOI: 10.1016/j.jacadv.2024.101543.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsDuration of DAPTRandomized controlled trialsPercutaneous coronary interventionShorter duration of dual antiplatelet therapyRisk of bleedingBleeding riskLow risk of bleedingSex-based differencesAssociated with lower riskAdverse clinical eventsDual antiplatelet therapyAdverse cardiovascular eventsNetwork meta-analysisWeb of Science databasesAntiplatelet therapyClinical impactCardiovascular eventsClinical eventsSystematic reviewSignificant sex-based differencesControlled trialsCoronary intervention
2024
Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention
Park D, Hu J, Jamil Y, Kelsey M, Jones W, Frampton J, Kochar A, Aronow W, Damluji A, Nanna M. Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention. JAMA Network Open 2024, 7: e244000. PMID: 38546647, PMCID: PMC10979312, DOI: 10.1001/jamanetworkopen.2024.4000.Peer-Reviewed Original ResearchConceptsOlder adultsMonths of DAPTDuration of dual antiplatelet therapySystematic reviewRandomized clinical trialsPercutaneous coronary interventionMeta-analysisPreferred Reporting ItemsAssess data qualityRisk of bleedingDuration of DAPTDual antiplatelet therapyWeb of ScienceMain OutcomesReporting ItemsData extractionAbstracted dataSecondary outcomesRisk ratioAntiplatelet therapyPrimary outcomeCochrane LibraryCoronary interventionReference groupNetwork meta-analysis
2022
Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic review
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