2009
Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells
Radtke C, Schmitz B, Spies M, Kocsis J, Vogt P. Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells. International Journal Of Developmental Neuroscience 2009, 27: 817-823. PMID: 19699793, DOI: 10.1016/j.ijdevneu.2009.08.006.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsStem cellsGlial-like cellsAdipose-derived mesenchymal stem cellsGlial cell differentiationPeripheral glial cellsGrowth factorEpidermal growth factorGrowth factor receptorMitogen withdrawalFibroblast growth factorBasic fibroblast growth factorCell differentiationDorsal root ganglion neuronsSchwann cell marker S100P75 nerve growth factor receptorAdipose-derived stem cellsNerve growth factor receptorCellular aggregatesSimultaneous expressionOlfactory Ensheathing CellsAppropriate inductionFactor receptorNeurospheresGlia markers
2001
Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord
Akiyama Y, Honmou O, Kato T, Uede T, Hashi K, Kocsis J. Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord. Experimental Neurology 2001, 167: 27-39. PMID: 11161590, DOI: 10.1006/exnr.2000.7539.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBrainBrain Tissue TransplantationCell DifferentiationCells, CulturedCerebral VentriclesClone CellsDemyelinating DiseasesFemaleGenes, ReporterHumansIntermediate Filament ProteinsMaleMiddle AgedMyelin SheathNerve Tissue ProteinsNestinNeural ConductionNeuronsRadiation Injuries, ExperimentalRatsRats, WistarSpinal CordStem Cell TransplantationStem CellsTransplantation, HeterologousConceptsAdult human brainRat spinal cordNestin-positive cellsNeural precursor cellsSpinal cordAdult rat spinal cordNormal conduction velocityHuman brainMitogen withdrawalSpinal cord resultsPrecursor cellsGlia-like cellsSchwann cell myelinationNeural progenitor cellsFunctional remyelinationP0 immunoreactivityRemyelinated axonsExtensive remyelinationCord resultsAnterior hornLateral ventricleSubventricular zoneMajority of cellsMyelin patternSchwann cells
2000
Excitability changes of dorsal root axons following nerve injury: implications for injury-induced changes in axonal Na+ channels
Nonaka T, Honmou O, Sakai J, Hashi K, Kocsis J. Excitability changes of dorsal root axons following nerve injury: implications for injury-induced changes in axonal Na+ channels. Brain Research 2000, 859: 280-285. PMID: 10719075, DOI: 10.1016/s0006-8993(00)01979-x.Peer-Reviewed Original ResearchConceptsDorsal root axonsNerve injuryDorsal rootsAction potentialsCutaneous afferent axonsSciatic nerve ligationAfferent cell bodiesInjury-induced changesRat dorsal rootSucrose gap chamberTarget disconnectionNerve ligationExcitability changesSpinal cordAfferent axonsTrophic supportRoot ligationRefractory periodCell bodiesElectrophysiological recordingsAxonsInjuryDepolarizationLigationPrevious studies
1998
Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Imaizumi T, Lankford K, Waxman S, Greer C, Kocsis J. Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord. Journal Of Neuroscience 1998, 18: 6176-6185. PMID: 9698311, PMCID: PMC2605360, DOI: 10.1523/jneurosci.18-16-06176.1998.Peer-Reviewed Original ResearchConceptsDorsal column axonsRat spinal cordSpinal cordRemyelinated axonsDorsal columnsAdult rat spinal cordExtent of remyelinationTransplantation of OECsSpinal cord lesionsCell injection siteQuantitative histological analysisFunctional remyelinationCord lesionsAxonal conductionNeonatal ratsFocal injectionsConduction blockSchwann cellsConduction velocityInjection siteElectrophysiological propertiesAction potentialsAxonsHistological analysisTransplantationPeripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo
Kenney A, Kocsis J. Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo. Journal Of Neuroscience 1998, 18: 1318-1328. PMID: 9454841, PMCID: PMC2605350, DOI: 10.1523/jneurosci.18-04-01318.1998.Peer-Reviewed Original ResearchConceptsC-Jun proteinC-JunC-Jun amino-terminal kinase 1Nerve injuryAxonal regenerationAmino-terminal phosphorylationLumbar dorsal root ganglion neuronsActivator protein-1 bindingEarly post-injury periodJun kinase activationAdult rat dorsal root gangliaDorsal root ganglion neuronsRat dorsal root gangliaKinase 1 activationC-Jun phosphorylationSciatic nerve injuryActivator protein-1 binding activityPost-injury periodSciatic nerve transectionAdult rat DRGDorsal root gangliaLong-term upregulationPeripheral axonal regenerationAP-1 bindingProtein-1 bindingMechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult rats
1997
Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia
Kenney A, Kocsis J. Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia. Brain Research 1997, 52: 53-61. PMID: 9450677, DOI: 10.1016/s0169-328x(97)00211-8.Peer-Reviewed Original ResearchConceptsDorsal root gangliaDorsal root transectionPeripheral axotomyDRG neuronsRoot transectionRoot gangliaProtein levelsAdult rat lumbar dorsal root gangliaRat lumbar dorsal root gangliaLumbar dorsal root gangliaAdult rat dorsal root gangliaRat dorsal root gangliaNeurotrophic factor administrationSpinal nerve transectionC-Jun protein levelsAdministration of NGFFactor protein levelsJunD protein levelsTarget disconnectionNerve transectionFactor administrationPeripheral branchesTransectionFactor levelsRapid elevation
1994
Calcium signals in neurons
Rand M, Leinders-Zufall T, Agulian S, Kocsis J. Calcium signals in neurons. Nature 1994, 371: 291-292. PMID: 8090198, DOI: 10.1038/371291b0.Peer-Reviewed Original ResearchIntracellular calcium mobilization and neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Intracellular calcium mobilization and neurite outgrowth in mammalian neurons. Developmental Neurobiology 1994, 25: 252-264. PMID: 8195789, DOI: 10.1002/neu.480250306.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCaffeineCalciumCalcium ChannelsCell CompartmentationCell DifferentiationCells, CulturedFemaleGanglia, SpinalGene Expression RegulationImage Processing, Computer-AssistedIntracellular FluidIon Channel GatingLasersMicroscopy, FluorescenceModels, BiologicalNeuritesNeuronsRatsRats, WistarTerpenesThapsigarginConceptsDepolarization-induced Ca2Calcium-induced calcium releaseDRG neuronsIntracellular Ca2Cultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsRat dorsal root ganglion neuronsNeurite outgrowthDorsal root ganglion neuronsIntact intracellular Ca2Intracellular calcium mobilizationIndicator dye fluo-3Nuclear Ca2Dye Fluo-3Endoplasmic reticulum Ca2Ganglion neuronsCalcium mobilizationDependent kinase IICalcium releaseFluo-3NeuronsMammalian neuronsReticulum Ca2Elevated Ca2Elicit neurite outgrowthNuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue
Utzschneider D, Rand M, Waxman S, Kocsis J. Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue. Brain Research 1994, 635: 231-237. PMID: 8173960, DOI: 10.1016/0006-8993(94)91444-3.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsEmbryonic DRG neuronsDepolarization-induced Ca2DRG neuronsGanglion neuronsRat dorsal root ganglion neuronsAdult dorsal root ganglion neuronsCytoplasmic Ca2Sensitive fluorescent dye fluo-3Rat DRG neuronsDorsal root gangliaExcised dorsal root gangliaFluorescent dye fluo-3Postnatal time periodsElevated extracellular potassiumEarly postnatal time periodsBrief electrical stimuliNuclear Ca2Dye Fluo-3Neonatal gangliaNeonatal neuronsTarget innervationRoot gangliaAdult neuronsEmbryonic neurons
1992
A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons
Pongracz F, Poolos N, Kocsis J, Shepherd G. A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. Journal Of Neurophysiology 1992, 68: 2248-2259. PMID: 1337105, PMCID: PMC2605954, DOI: 10.1152/jn.1992.68.6.2248.Peer-Reviewed Original ResearchConceptsReceptor-mediated conductanceExcitatory postsynaptic potentialsPyramidal neuronsSynaptic responsesSynaptic activationSize of EPSPsExtracellular ion concentration changesNMDA receptor-mediated activityCA1 hippocampal pyramidal cellsCA1 hippocampal pyramidal neuronsHippocampal CA1 pyramidal neuronsDendritic NMDA receptorsRepetitive synaptic activationCA1 pyramidal neuronsInhibitory synaptic responsesFrequency-dependent depressionHippocampal pyramidal neuronsNMDA receptor activationHippocampal pyramidal cellsExtracellular potassium accumulationRepetitive activityIntrinsic membrane conductancesReceptor-mediated activityHz. 4Spike afterdepolarizationMutual excitation among dorsal root ganglion neurons in the rat
Utzschneider D, Kocsis J, Devor M. Mutual excitation among dorsal root ganglion neurons in the rat. Neuroscience Letters 1992, 146: 53-56. PMID: 1475049, DOI: 10.1016/0304-3940(92)90170-c.Peer-Reviewed Original ResearchConceptsDorsal root gangliaDorsal rootsDorsal root ganglion neuronsPrimary sensory neuronsExcised dorsal root gangliaNerve injuryDRG neuronsGanglion neuronsMost neuronsRoot gangliaSensory abnormalitiesIntracellular recordingsDR stimulationRepetitive stimulationSensory neuronsTransient riseNeighboring neuronsNeuronsStimulationSimilar kineticsMutual excitationGangliaInjuryRatsAbnormalities
1987
Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs
Peroutka S, Mauk M, Kocsis J. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs. Neuropharmacology 1987, 26: 139-146. PMID: 2884586, DOI: 10.1016/0028-3908(87)90201-2.Peer-Reviewed Original ResearchConceptsTVX Q 7821Hippocampal slice preparationSlice preparationDose-dependent mannerMicromolar concentrationsApplication of drugsPopulation spikesRadioligand techniquesOH-DPATSchaffer collateralsHippocampal membranesNeuronal activityPyramidal layerKetanserinBaseline levelsBuspironeInitial increaseDPATSelective drugsDrugsField potentialsPhysiological effectsPopulationSimilar affinityBenzisothiazol-3
1979
A supernormal period in central axons following single cell stimulation
Kocsis J, VanderMaelen C. A supernormal period in central axons following single cell stimulation. Experimental Brain Research 1979, 36: 381-386. PMID: 488207, DOI: 10.1007/bf00238919.Peer-Reviewed Original Research