2006
Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
Dombrowski MA, Sasaki M, Lankford KL, Kocsis JD, Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Research 2006, 1125: 1-8. PMID: 17112480, PMCID: PMC2673087, DOI: 10.1016/j.brainres.2006.09.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell Adhesion Molecules, NeuronalCell TransplantationGreen Fluorescent ProteinsImmunohistochemistryMicroscopy, ImmunoelectronMyelin SheathNAV1.6 Voltage-Gated Sodium ChannelNerve RegenerationNeurofilament ProteinsNeurogliaOlfactory BulbRanvier's NodesRatsRats, Sprague-DawleySciatic NeuropathySodium ChannelsTime FactorsConceptsPeripheral nerve fibersPeripheral nervesNodes of RanvierFunctional outcomeAxonal regenerationNerve fibersRegenerated peripheral nerve fibersSciatic nerve crush lesionNerve crush lesionPeripheral-type myelinSpinal cord resultsTransplantation of olfactoryPeripheral axonal regenerationParanodal CasprCrush lesionCord resultsFunctional improvementOlfactory bulbTransection siteTransgenic ratsLesion zoneNerveNodal formationTransplantation siteOECs
2001
Hepatocyte growth factor is a mitogen for olfactory ensheathing cells
Yan H, Nie X, Kocsis J. Hepatocyte growth factor is a mitogen for olfactory ensheathing cells. Journal Of Neuroscience Research 2001, 66: 698-704. PMID: 11746390, PMCID: PMC2605377, DOI: 10.1002/jnr.10009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBrain Tissue TransplantationCell DivisionCell SizeCell SurvivalCells, CulturedColforsinCulture Media, Serum-FreeCyclic AMPDose-Response Relationship, DrugDrug InteractionsFemaleGlial Fibrillary Acidic ProteinHepatocyte Growth FactorImmunohistochemistryMitogensNeurogliaOlfactory BulbProto-Oncogene Proteins c-metRatsRats, WistarReceptor, Nerve Growth FactorS100 ProteinsTrauma, Nervous SystemConceptsHepatocyte growth factorActivity of HGFAdult rat olfactory bulbHGF/c-Met systemGrowth factorOEC proliferationMitogenic activityOlfactory Ensheathing CellsRat olfactory bulbAbility of HGFC-Met receptorAddition of forskolinCultured OECsOlfactory bulbVariety of cellsDNA synthesisC-MetSerum-free mediumPotential mitogenic activityPotent mitogenMulti-functional effectsImmunocytochemical analysisCell proliferationOlfactory systemOECsTransplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons
Sasaki M, Honmou O, Akiyama Y, Uede T, Hashi K, Kocsis J. Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 2001, 35: 26-34. PMID: 11424189, PMCID: PMC2605363, DOI: 10.1002/glia.1067.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBeta-GalactosidaseBone Marrow TransplantationCells, CulturedEthidiumGlial Fibrillary Acidic ProteinImmunohistochemistryMiceMice, TransgenicMyeloid Progenitor CellsNerve Fibers, MyelinatedNerve RegenerationNeurogliaRatsRats, WistarRecovery of FunctionSpinal CordSpinal Cord InjuriesConceptsBone marrow cellsSpinal cordMyelin-forming cellsMarrow cellsDemyelinated rat spinal cordRat spinal cord axonsDorsal column lesionBone marrow cell fractionRat spinal cordX-irradiation treatmentSpinal cord axonsLacZ transgenic miceSchwann cell myelinationCell fractionCell transplantation techniquesDorsal funiculusPeripheral patternTransgenic miceTransplantation techniquesHematopoietic stem cellsIsolated cell fractionsCordFemoral bonePrecursor cellsTransplantation
2000
Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
Kato T, Honmou O, Uede T, Hashi K, Kocsis J. Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord. Glia 2000, 30: 209-218. PMID: 10756071, PMCID: PMC2605375, DOI: 10.1002/(sici)1098-1136(200005)30:3<209::aid-glia1>3.0.co;2-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCation Transport ProteinsCell SizeCells, CulturedDemyelinating DiseasesDNA ProbesFemaleFungal ProteinsHumansIn Situ HybridizationMembrane Transport ProteinsMicroscopy, ElectronMiddle AgedMyelin SheathNeurogliaOlfactory NerveRatsRats, WistarSaccharomyces cerevisiae ProteinsSpinal CordConceptsSpinal cordDemyelinated rat spinal cordHuman olfactoryImmunosuppressed adult ratsDemyelinated spinal cordAdult mammalian CNSRat spinal cordExtensive remyelinationHuman OECsDemyelinated axonsOlfactory nervePeripheral typeSchwann cellsAdult ratsLesion siteMammalian CNSMyelin sheathRemyelinationCordAxonsSitu hybridizationSimilar numberOlfactoryCellsLarge nuclei