Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers
Bowe C, Kocsis J, Targ E, Waxman S. Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers. Annals Of Neurology 1987, 22: 264-268. PMID: 2821876, DOI: 10.1002/ana.410220212.Peer-Reviewed Original ResearchConceptsSensory fibersClinical trialsAction potentialsPotassium channel blockadeDorsal root axonsCompound action potentialDorsal spinal rootsSingle action potentialMammalian motorIntrathecal injectionMultiple sclerosisSensory dysfunctionVentral rootsSpinal rootsNeuromuscular disordersSpecific fiber typesElectrophysiological responsesSingle stimulusPhysiological effectsTrialsFiber typesResponseParesthesiaSclerosisDysfunctionModulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs
Peroutka S, Mauk M, Kocsis J. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs. Neuropharmacology 1987, 26: 139-146. PMID: 2884586, DOI: 10.1016/0028-3908(87)90201-2.Peer-Reviewed Original ResearchConceptsTVX Q 7821Hippocampal slice preparationSlice preparationDose-dependent mannerMicromolar concentrationsApplication of drugsPopulation spikesRadioligand techniquesOH-DPATSchaffer collateralsHippocampal membranesNeuronal activityPyramidal layerKetanserinBaseline levelsBuspironeInitial increaseDPATSelective drugsDrugsField potentialsPhysiological effectsPopulationSimilar affinityBenzisothiazol-3