2024
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024, 97: 651-658. PMID: 39395473, PMCID: PMC11839384, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylase
2015
Reference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET
Sandiego CM, Gallezot JD, Lim K, Ropchan J, Lin SF, Gao H, Morris ED, Cosgrove KP. Reference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 623-629. PMID: 25564239, DOI: 10.1038/jcbfm.2014.237.Peer-Reviewed Original ResearchConceptsPositron emission tomographyExtrastriatal regionsBrain regionsAmphetamine-induced dopamine releaseHealthy tobacco smokersExtrastriatal brain regionsSynaptic dopamine levelsAmphetamine-induced changesSimplified reference tissue modelReference tissue modelTobacco smokersDopaminergic dysfunctionAmphetamine administrationDopamine levelsDopamine releasePsychiatric disordersChallenge studiesDistribution volumeEmission tomographyD3 bindingReference region modelCerebellumReference regionBaselineSignificant changes
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