2024
Open Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeteransPrescription Drug Prices: An AAN Position Statement.
Santoro J, Sico J, Burke J, Sarkar K, Turbes M, Evans D, Jordan J. Prescription Drug Prices: An AAN Position Statement. Neurology 2024, 102: e209132. PMID: 38335469, DOI: 10.1212/wnl.0000000000209132.Peer-Reviewed Original ResearchConceptsHigh cost of medicationNeurological disordersDevelopment of novel therapeuticsNeurological diseasesOrphan Drug ActTherapeutic optionsCost of medicationsHigh-value careCost of prescription drugsPrescription drug pricesRare diseaseTreat rare diseasesPatientsNovel therapeuticsTreat neurological disordersDrug ActCost containment effortsChronic neurological conditionsEffective prescription medicationsMedicationPrescriber accessPrescription medicationsTherapyHealthcare systemApproval pathway
2022
Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study)
Berg C, Patel B, Reynolds M, Tuzovic M, Chew K, Sico J, Bhattacharya D, Butt A, Lim J, Bedimo R, Brown S, Gottdiener J, Warner A, Freiberg M, So-Armah K, Nguyen K. Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study). The American Journal Of Cardiology 2022, 186: 50-57. PMID: 36343446, PMCID: PMC10193525, DOI: 10.1016/j.amjcard.2022.10.035.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionDiastolic functionAtrial mechanicsLA strainHuman immunodeficiency virus (HIV) infectionLogistic regressionCross-sectional cohort analysisCohort of PLWHHIV uninfected controlsLA conduit strainLA phasic strainLA reservoir strainLeft Atrial MechanicsLV diastolic dysfunctionHIV viral loadHIV viral suppressionImmunodeficiency virus infectionVentricular diastolic functionHuman immunodeficiency virusPropensity weightingPLWH cohortSubclinical cardiomyopathyAntiretroviral therapyCardiovascular deathViral suppressionCharacteristics and Gender Differences of Headache in the Veterans Health Administration
Sico JJ, Seng E, Wang K, Skanderson M, Schindler E, Ney JP, Lorenze N, Kimber A, Lindsey H, Grinberg AS, Kuruvilla D, Higgins D, Graham G, Sandbrink F, Scholten J, Shapiro RE, Lipton RB, Fenton B. Characteristics and Gender Differences of Headache in the Veterans Health Administration. Neurology 2022, 99: e1993-e2005. PMID: 36100437, PMCID: PMC9651459, DOI: 10.1212/wnl.0000000000200905.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisHealthcare utilizationIncidence rateHeadache careHeadache typesHealth AdministrationSociodemographic characteristicsMilitary-related exposuresAge-adjusted incidenceEmergency department utilizationElectronic health record dataRetrospective cohort designType of headacheHigh incidence rateTraumatic brain injuryUnited States veteransHealth record dataPost-traumatic stress disorderGender differencesMilitary sexual traumaHeadache disordersBrain injuryHeadache specialistsCohort designFrequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine
Seng EK, Fenton BT, Wang K, Lipton RB, Ney J, Damush T, Grinberg AS, Skanderson M, Sico JJ. Frequency, Demographics, Comorbidities, and Health Care Utilization by Veterans With Migraine. Neurology 2022, 99: e1979-e1992. PMID: 36100439, PMCID: PMC9651466, DOI: 10.1212/wnl.0000000000200888.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHealth care utilizationStudy periodCare utilizationHealth AdministrationOne-year period prevalenceOverweight/obesityMental health disordersChi-square testStudent's t-testMilitary sexual traumaAnnual encountersHeadache comorbidityPain comorbiditiesCohort entryCommon comorbiditiesPain disordersTotal cohortAnnual incidenceHealthcare utilizationHigher proportionPeriod prevalenceEmergency departmentMigraine carePrimary careMilitary sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women
Gaffey AE, Rosman L, Sico JJ, Haskell SG, Brandt CA, Bathulapalli H, Han L, Dziura J, Skanderson M, Burg MM. Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women. Journal Of Hypertension 2022, 40: 2307-2315. PMID: 35983872, DOI: 10.1097/hjh.0000000000003267.Peer-Reviewed Original ResearchConceptsIncident hypertensionRisk factorsPsychiatric disordersMultivariate Cox proportional hazards modelVeterans Health Administration dataGreater riskCox proportional hazards modelTrauma-related psychiatric disordersMiddle-aged veteransCardiovascular risk factorsBaseline blood pressureElevated cardiovascular riskLarge prospective cohortHealth Administration dataMiddle-aged menProportional hazards modelSex-specific analysesPosttraumatic stress disorderMilitary sexual traumaCardiovascular riskCohort studyProspective cohortBlood pressureTreatment attenuatesCardiovascular impactPairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design
Miech EJ, Perkins AJ, Zhang Y, Myers LJ, Sico JJ, Daggy J, Bravata DM. Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design. BMJ Open 2022, 12: e061469. PMID: 35672067, PMCID: PMC9174826, DOI: 10.1136/bmjopen-2022-061469.Peer-Reviewed Original ResearchConceptsTransient ischemic attackLogistic regression modelsHealth services researchSet of patientsOverall sample prevalenceObservational cohortLogistic regressionSample prevalenceRecurrent ischemic strokeVeterans Affairs hospitalRegression modelsServices researchIschemic attackRecurrent strokeCause mortalityCombined endpointIschemic strokePatient outcomesDeath outcomesCare outcomesPatientsSecondary analysisPrevalenceOutcomesCohortTelehealth perceptions and utilization for the delivery of headache care before and during the COVID‐19 pandemic: A mixed‐methods study
Grinberg AS, Fenton BT, Wang K, Lindsey H, Goldman RE, Baird S, Riley S, Burrone L, Seng EK, Damush TM, Sico JJ. Telehealth perceptions and utilization for the delivery of headache care before and during the COVID‐19 pandemic: A mixed‐methods study. Headache The Journal Of Head And Face Pain 2022, 62: 613-623. PMID: 35545754, PMCID: PMC9348149, DOI: 10.1111/head.14310.Peer-Reviewed Original ResearchConceptsVeterans Health Administration facilitiesTelehealth deliveryHeadache centerHeadache careAdministration facilitiesCoronavirus disease 2019 (COVID-19) pandemicUtilization of telehealthDisease 2019 pandemicRace/ethnicityPatient ageTelephone visitsPerson appointmentsTelehealth visitsOutpatient visitsPatient groupPatient preferencesHeadache disordersPerson visitsHeadache treatmentMultiple delivery methodsPatientsPatient engagementProviders' perceptionsHeadache servicesPatient accessRelationship Between Headache Characteristics and a Remote History of TBI in Veterans
Coffman C, Reyes D, Hess MC, Giakas AM, Thiam M, Sico JJ, Seng E, Renthal W, Rhoades C, Cai G, Androulakis XM. Relationship Between Headache Characteristics and a Remote History of TBI in Veterans. Neurology 2022, 99: e187-e198. PMID: 35470141, PMCID: PMC9280992, DOI: 10.1212/wnl.0000000000200518.Peer-Reviewed Original ResearchConceptsMigraine-like featuresAlteration of consciousnessAdjusted odds ratioHeadache severityHeadache outcomesSevere headacheMild TBIPosttraumatic amnesiaTBI evaluationRetrospective chart reviewTraumatic brain injury severityComprehensive TBI evaluationBrain injury severityMental health diagnosesUnique risk factorsDose-response relationshipGreater headache severityRace/ethnicityNonblast injuriesChart reviewInjury characteristicsTBI severity groupsRemote historyRisk factorsSevere TBIEssential components of care in a multidisciplinary headache center: Perspectives from headache neurology specialists
Goldman RE, Damush TM, Kuruvilla DE, Lindsey H, Baird S, Riley S, BS L, Grinberg AS, Seng EK, Fenton BT, Sico JJ. Essential components of care in a multidisciplinary headache center: Perspectives from headache neurology specialists. Headache The Journal Of Head And Face Pain 2022, 62: 306-318. PMID: 35293614, DOI: 10.1111/head.14277.Peer-Reviewed Original ResearchConceptsMultidisciplinary headache centerHeadache centerHeadache careNeurology specialistsChronic headacheIntegrative health modalitiesBotulinum toxin injectionImmersion/crystallization techniqueType of careSemi-structured telephone interviewsBehavioral health practitionersCognitive behavioral therapyToxin injectionMultidisciplinary careNerve blockPain managementUnsuccessful treatmentHeadache specialistsNew medicationsPhysical therapySuccessful careMultiple doctorsPatientsOccupational therapySleep medicineBlood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack
Arling G, Perkins A, Myers LJ, Sico JJ, Bravata DM. Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack. The American Journal Of Medicine 2022, 135: 889-896.e1. PMID: 35292287, DOI: 10.1016/j.amjmed.2022.02.012.Peer-Reviewed Original ResearchConceptsSystolic blood pressure trajectoriesTransient ischemic attackSystolic blood pressureBlood pressure trajectoriesBlood pressureAntihypertensive medicationsIschemic attackPressure trajectoriesHigher systolic blood pressureLower systolic blood pressureCox proportional hazards modelBlood pressure reductionBlood pressure controlEmergency department visitsHazard of mortalityProportional hazards modelVA Medical CenterMedication intensificationCause mortalityVascular eventsIschemic strokeRetrospective cohortDepartment visitsHypertension managementIndex eventComplementary and integrative medicine perspectives among veteran patients and VHA healthcare providers for the treatment of headache disorders: a qualitative study
Kuruvilla DE, Lindsey H, Grinberg AS, Goldman RE, Riley S, Baird S, Fenton BT, Sico JJ, Damush TM. Complementary and integrative medicine perspectives among veteran patients and VHA healthcare providers for the treatment of headache disorders: a qualitative study. BMC Complementary Medicine And Therapies 2022, 22: 22. PMID: 35078450, PMCID: PMC8790919, DOI: 10.1186/s12906-022-03511-6.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeteran patientsHeadache managementClinical providersBackgroundThe Veterans Health AdministrationFavorable adverse effect profileVHA healthcare providersAdverse effect profileManagement of veteransChronic headache managementCIM modalitiesWhole health systemEffect profileHeadache centerChronic headacheHeadache disordersPatients' perceptionsHeadache treatmentSafe additionPatientsTreatment efficacyIntegrative medicineHealth AdministrationProviders' perceptionsHealthcare providersThe Primary Care Management of Headache: Synopsis of the 2020 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
Sico JJ, Macedo F, Lewis J, Spevak C, Vogsland R, Ford A, Skop K, Sall J. The Primary Care Management of Headache: Synopsis of the 2020 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline. Military Medicine 2022, 187: e1091-e1102. PMID: 35022782, DOI: 10.1093/milmed/usab490.Peer-Reviewed Original ResearchConceptsClinical practice guidelinesPractice guidelinesDefense Clinical Practice GuidelineJoint clinical practice guidelineTrustworthy clinical practice guidelinesPractice Work GroupMedication overuse headachePrimary care managementPreferences of patientsGuideline development panelMedicine's tenetsPharmacologic managementRecommendations AssessmentOveruse headacheGuideline panelCare managementHeadacheDevelopment panelVeterans AffairsClinical stakeholdersPatientsGuidelinesIndividual needsDepartmentPrevention
2021
Cluster Headache: Clinical Characteristics and Opportunities to Enhance Quality of Life
Grinberg AS, Best RD, Min KM, Schindler EAD, Koo BB, Sico JJ, Seng EK. Cluster Headache: Clinical Characteristics and Opportunities to Enhance Quality of Life. Current Pain And Headache Reports 2021, 25: 65. PMID: 34668084, DOI: 10.1007/s11916-021-00979-8.Peer-Reviewed Original ResearchConceptsQuality of lifeCluster headacheCommon psychiatric comorbiditiesCurrent clinical carePsychological treatmentPrimary headache disordersRecent FindingsPeopleClinical characteristicsSevere painPsychiatric comorbidityDisease burdenHeadache disordersClinical careDepressive symptomsGeneral populationHeadacheSuicidal ideationAutonomic featuresBehavioral interventionsCommitment TherapyPsychological factorsTreatmentBurdenComorbiditiesPainDepression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study
Sico JJ, Kundu S, So‐Armah K, Gupta SK, Chang C, Butt AA, Gibert CL, Marconi VC, Crystal S, Tindle HA, Freiberg MS, Stewart JC. Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study. Journal Of The American Heart Association 2021, 10: e017637. PMID: 34169726, PMCID: PMC8403311, DOI: 10.1161/jaha.119.017637.Peer-Reviewed Original ResearchConceptsHIV-positive peopleBaseline antidepressant useCerebrovascular risk factorsRisk of strokeRisk factorsAlcohol use disorderStroke riskAntidepressant useUse disordersCocaine useSociodemographic characteristicsTraditional cerebrovascular risk factorsVeterans Aging Cohort StudyCox proportional hazards modelBackground HIV infectionHIV-specific factorsIndividual antiretroviral agentsAntiretroviral therapy useBaseline cardiovascular diseaseIndependent risk factorAging Cohort StudyIschemic stroke riskHIV-positive veteransProportional hazards modelUninfected veteransHospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence
Levine DA, Perkins AJ, Sico JJ, Myers LJ, Phipps MS, Zhang Y, Bravata DM. Hospital Factors, Performance on Process Measures After Transient Ischemic Attack, and 90-Day Ischemic Stroke Incidence. Stroke 2021, 52: 2371-2378. PMID: 34039034, PMCID: PMC8238890, DOI: 10.1161/strokeaha.120.031721.Peer-Reviewed Original ResearchConceptsIschemic stroke incidenceStroke incidenceHospital factorsPhysician staffingTIA patientsHypertension controlProcess measuresModerate potency statinTransient ischemic attackDays of dischargeEmergency department dischargeVeterans Affairs hospitalEligible patientsIschemic attackStatin useAntithrombotic useEmergency departmentEmergency physiciansInpatient unitDay 2HospitalPatient volumeFiscal year 2015PatientsIncidenceBenefits and Risks of Dual Versus Single Antiplatelet Therapy for Secondary Stroke Prevention: A Systematic Review for the 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Brown DL, Levine DA, Albright K, Kapral MK, Leung LY, Reeves MJ, Sico J, Strong B, Whiteley WN, Council O. Benefits and Risks of Dual Versus Single Antiplatelet Therapy for Secondary Stroke Prevention: A Systematic Review for the 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 2021, 52: e468-e479. PMID: 34024115, DOI: 10.1161/str.0000000000000377.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapySingle antiplatelet therapyTransient ischemic attackHigh-risk transient ischemic attackIschemic stroke preventionRecurrent ischemic strokeIschemic attackIschemic strokeAntiplatelet therapyStroke preventionMajor bleedingRelative riskTreatment durationAmerican Heart Association/American Stroke AssociationSystematic reviewSecondary ischemic stroke preventionSecondary stroke preventionPrevention of strokeUnadjusted relative riskAmerican Stroke AssociationSecondary ischemic strokeDuration of treatmentLonger duration treatmentShort-duration trialsRecurrent strokeDeintensification or No Statin Treatment Is Associated With Higher Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack
Dearborn-Tomazos JL, Hu X, Bravata DM, Phadke MA, Baye FM, Myers LJ, Concato J, Zillich AJ, Reeves MJ, Sico JJ. Deintensification or No Statin Treatment Is Associated With Higher Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack. Stroke 2021, 52: 2521-2529. PMID: 34015937, DOI: 10.1161/strokeaha.120.030089.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeIschemic attackHospital dischargeHospital admissionHigh mortalityVeterans Health Administration facilitiesHigh-potency statinsUnderutilization of statinsHigh potencyStatin doseStatin medicationBaseline characteristicsMost patientsPrescribed statinsStatin treatmentPharmacy filesStatin potencyAtherosclerotic originUS veteransPractice guidelinesStudy populationHigher oddsPatientsStatinsDemoralization predicts suicidality in patients with cluster headache
Koo BB, Bayoumi A, Albanna A, Abusuliman M, Burrone L, Sico JJ, Schindler EAD. Demoralization predicts suicidality in patients with cluster headache. The Journal Of Headache And Pain 2021, 22: 28. PMID: 33879041, PMCID: PMC8056539, DOI: 10.1186/s10194-021-01241-7.Peer-Reviewed Original ResearchConceptsLifetime suicidal ideationSuicidal ideationHigh suicide riskSuicide riskControl participantsDiagnostic criteriaBrief Lifetime Depression ScaleObservational case-control studyLifetime depression historyColumbia-Suicide Severity Rating ScaleCluster headache patientsCase-control studyEdition diagnostic criteriaActive suicidal ideationStepwise logistic regressionSeverity Rating ScaleCH sufferersLittle empiric dataOrbital painCH diagnosisCluster headacheHeadache patientsHeadache disordersDepression ScaleSuicidal Behaviors QuestionnairePresence of Stigma in the Treatment of Patients With Migraine Among Neurologists
Zubair AS, Sico JJ, Kuruvilla DE. Presence of Stigma in the Treatment of Patients With Migraine Among Neurologists. Pain Medicine 2021, 22: 2135-2138. PMID: 33846739, DOI: 10.1093/pm/pnaa465.Peer-Reviewed Original Research