Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, Núñez-RĂos D, Zannas A, Zhao X, Aiello A, Ashley-Koch A, Avetyan D, Baker D, Beckham J, Boks M, Brick L, Bromet E, Champagne F, Chen C, Dalvie S, Dennis M, Fatumo S, Fortier C, Galea S, Garrett M, Geuze E, Grant G, Hauser M, Hayes J, Hemmings S, Huber B, Jajoo A, Jansen S, Kessler R, Kimbrel N, King A, Kleinman J, Koen N, Koenen K, Kuan P, Liberzon I, Linnstaedt S, Lori A, Luft B, Luykx J, Marx C, McLean S, Mehta D, Milberg W, Miller M, Mufford M, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff C, Nugent N, Orcutt H, Qin X, Rauch S, Ressler K, Risbrough V, Rutembesa E, Rutten B, Seedat S, Stein D, Stein M, Toikumo S, Ursano R, Uwineza A, Verfaellie M, Vermetten E, Vinkers C, Ware E, Wildman D, Wolf E, Young R, Zhao Y, van den Heuvel L, Uddin M, Nievergelt C, Smith A, Logue M. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Medicine 2024, 16: 147. PMID: 39696436, PMCID: PMC11658418, DOI: 10.1186/s13073-024-01417-1.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDNA methylationPsychiatric Genomics ConsortiumPost-traumatic stress disorderAssociation studiesMeta-analysis of epigenome-wide association studiesMethylation levelsGenome-wide expression dataEpigenetic gene regulationBrain regionsPGC-PTSDAnnotated genesBlood cell proportionsCpG lociGene regulationSusceptibility to post-traumatic stress disorderExpression dataAssociated with post-traumatic stress disorderIllumina HumanMethylation450Genomics ConsortiumOccurrence of post-traumatic stress disorderAssociated with biological differencesCpGMultiple brain regionsPostmortem brain samplesT7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION
Garayua A, Nunez D, Nagamatsu S, Giusti-Rodriguez P, Martinez-Gonzalez K, Montalvo-Ortiz J. T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION. European Neuropsychopharmacology 2024, 87: 159. DOI: 10.1016/j.euroneuro.2024.08.317.Peer-Reviewed Original ResearchPost-traumatic stress disorderMajor depressive disorderCOVID-19 related stressorsCOVID-19 stressorsMajor depressive disorder symptomsPost-traumatic stress disorder symptomsAccelerated epigenetic agingRelated stressorsCombined sex analysesSymptoms of major depressive disorderPsychiatric disorder symptomsCOVID-19-related stressorsSex-stratified analysesSelf-report measuresCOVID-related stressorsAdverse mental health outcomesTargeted mental health interventionsSignificant stressorsAt-risk populationsMental health interventionsMental health outcomesConsequences of stressorsAccelerated biological agingEpigenetic ageAt-riskThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original ResearchPost-traumatic stress disorderStress disorderPost-traumaticOpioid misuseComorbidityDisordersOpioidMisuseMulti-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder
Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.Peer-Reviewed Original Research
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