Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder
Pathak G, Pietrzak R, Levey D, Montalvo‐Ortiz J, Kranzler H, Gelernter J, Polimanti R. Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder. Alzheimer's & Dementia 2024, 20: e086508. PMCID: PMC11710760, DOI: 10.1002/alz.086508.Peer-Reviewed Original ResearchEpigenome-wide association studiesGenetic susceptibility to ADSusceptibility to ADCpG sitesPolygenic scoresAD pathogenesisAlzheimer's diseaseTOPMed reference panelEuropean ancestry participantsIllumina EPIC arrayBrain lipid metabolismCpG associationsAssociation studiesIdentified genesGenotype dataGenetic ancestryImprove statistical powerReference panelAncestry participantsEPIC arrayBonferroni significanceCpGMethylation intensityAlcohol use disorder diagnosisRisk of neurodegenerationExamining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder
Pathak G, Pietrzak R, Levey D, Montalvo‐Ortiz J, Kranzler H, Gelernter J, Polimanti R. Examining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder. Alzheimer's & Dementia 2024, 20: e093693. PMCID: PMC11712840, DOI: 10.1002/alz.093693.Peer-Reviewed Original ResearchEpigenome-wide association studiesGenetic susceptibility to ADSusceptibility to ADCpG sitesPolygenic scoresAD pathogenesisAlzheimer's diseaseTOPMed reference panelEuropean ancestry participantsIllumina EPIC arrayBrain lipid metabolismCpG associationsAssociation studiesIdentified genesGenotype dataGenetic ancestryImprove statistical powerReference panelAncestry participantsEPIC arrayBonferroni significanceCpGMethylation intensityAlcohol use disorder diagnosisRisk of neurodegenerationNeuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylation
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