Research & Publications
I obtained my BS in Biochemistry and Molecular Biology from the University of New Hampshire, and PhD in Biochemistry from the University of Wisconsin--Madison. My research career has always focused on transcriptional regulation of cell fate. This has included NFATc1 in osteoclasts, the Vitamin D Receptor in osteoblasts, and EBF1 in mesenchymal progenitors.
Currently I am researching the actions of EBF1 in mesenchymal development. In the bone this involves the actions of EBF1 in the vascular support cells (pericytes) to regulate bone vascularity, anabolism, and adipocyte differentiation. We have identified that the marrow adipocytes are a very different form of cell than arises in other locations and this is primarily highlighted by the different way that these cells rely upon the presence of EBF1. In the kidney EBF1 also participates in regulation of renal development and disease progression through it's ability of mesenchymal cells to modulate the vascularity of the glomerulus. Our work in kidney is also tied back to bone through the investigation of the pathology underlying chronic kidney disease-mineral bone disorders.
Education & Training
- PhDUniversity of Wisconsin-Madison, Biochemistry (2007)
- BSUniversity of New Hampshire, Biochemistry and Molecular Biology (2002)
- Research ScientistYale School of Medicine
- Postdoctoral FellowshipYale School of Medicine
Honors & Recognition
|John Haddad Young Investigator Award||American Society for Bone and Mineral Research||2010|
|Young Investigator Award||American Society for Bone and Mineral Research||2009|