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Jackie Fretz, PhD

Research Associate 3 MS; Manager of Histology and Histomorphometry Laboratory, Orthopaedics & Rehabilitation

Contact Information

Jackie Fretz, PhD

Lab Location

Office Location

Mailing Addresses

  • Yale School of Medicine

    47 College Street, PO Box 208071, MORTHO

    New Haven, CT, 06510

    United States

  • Yale School of Medicine

    330 Cedar Cedar Street, Orthopaedics Histology Laboratory

    New Haven, Connecticut, 06510

    United States

Biography

I obtained my BS in Biochemistry and Molecular Biology from the University of New Hampshire, and PhD in Biochemistry from the University of Wisconsin--Madison. My research career has focused on transcriptional regulation of cell fate. This has included NFATc1 in osteoclasts, the Vitamin D Receptor in osteoblasts, and EBF1 in mesenchymal progenitors.

Currently I am investigating the actions of EBF1 in mesenchymal progenitors and perivascular cells. In the bone this involves the actions of EBF1 in the vascular support cells (pericytes) to regulate bone vascularity, anabolism, and adipocyte differentiation. We have identified that the marrow adipocytes are a very different form of fat-storing cell than arises in other anatomical locations. This is primarily highlighted by the different way that these cells rely upon the presence of EBF1. Most interestingly Our investigations have revealed that EBF1 is essential to properly mobilize osteoblast progenitors into the bone lineage in the aging adult skeleton and following injury to mediate repair.

In the kidney EBF1 also participates in regulation of renal development and disease progression through it's ability of mesenchymal cells to modulate the vascularity of the glomerulus. Within the adult kidney podocytes use EBF1 to respond to glomerular injury and propagate sclerosis. Our work in kidney is also tied back to bone through the investigation of the pathology underlying chronic kidney disease-mineral bone disorders including regulation of FGF-23 in early chronic kidney disease.

Education & Training

  • PhD
    University of Wisconsin-Madison, Biochemistry (2007)
  • BS
    University of New Hampshire, Biochemistry and Molecular Biology (2002)
  • Research Scientist
    Yale School of Medicine
  • Postdoctoral Fellowship
    Yale School of Medicine

Honors & Recognition

AwardAwarding OrganizationDate
John Haddad Young Investigator AwardAmerican Society for Bone and Mineral Research2010
Young Investigator AwardAmerican Society for Bone and Mineral Research2009

Departments & Organizations