Jackie Fretz, PhD

Research Associate 3 MS; Assistant Professor of Pathology

Contact Information

Jackie Fretz, PhD

Lab Location

Office Location

Mailing Address

  • Orthopaedics & Rehabilitation

    PO Pox 708071, MORTHO

    New Haven, Connecticut, 06520-8071

    United States

Jackie Fretz
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Biography

I obtained my BS in Biochemistry and Molecular Biology from the University of New Hampshire, and PhD in Biochemistry from the University of Wisconsin--Madison. My research career has always focused on transcriptional regulation of cell fate. This has included NFATc1 in osteoclasts, the Vitamin D Receptor in osteoblasts, and EBF1 in mesenchymal progenitors. 

 Currently I am researching the actions of EBF1 in mesenchymal development. In the bone this involves the actions of EBF1 in the vascular support cells (pericytes) to regulate bone vascularity, anabolism, and adipocyte differentiation. We have identified that the marrow adipocytes are a very different form of cell than arises in other locations and this is primarily highlighted by the different way that these cells rely upon the presence of EBF1. In the kidney EBF1 also participates in regulation of renal development and disease progression through it's ability of mesenchymal cells to modulate the vascularity of the glomerulus.  Our work in kidney is also tied back to bone through the investigation of the pathology underlying chronic kidney disease-mineral bone disorders.

Education & Training

  • PhD
    University of Wisconsin-Madison, Biochemistry (2007)
  • BS
    University of New Hampshire, Biochemistry and Molecular Biology (2002)
  • Research Scientist
    Yale School of Medicine
  • Postdoctoral Fellowship
    Yale School of Medicine

Honors & Recognition

AwardAwarding OrganizationDate
John Haddad Young Investigator AwardAmerican Society for Bone and Mineral Research2010
Young Investigator AwardAmerican Society for Bone and Mineral Research2009

Departments & Organizations