2023
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study
Ralevski E, Newcomb J, Pisani E, DeNegre D, Peltier M, Jane J, Yoon G, Petrakis I. Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study. Journal Of Dual Diagnosis 2023, 20: 39-51. PMID: 38147491, PMCID: PMC11214330, DOI: 10.1080/15504263.2023.2294989.Peer-Reviewed Original ResearchAlcohol use disorderStress-induced cravingCognitive performanceNegative affectNeutral scriptsStress disorderPost-traumatic stress disorderComorbid alcohol use disorderTraumatic Stress DisorderMeasures of cravingCurrent alcohol use disorderPositive emotionsTrauma scriptsPhysiological measuresCravingStress-induced symptomsTest sessionsPTSDAnxietyAffectUse disordersLaboratory sessionsCocaine dependenceAlcohol dependenceIndividuals
2016
Alcohol Use Disorders and Comorbid Post-Traumatic Stress Disorder in US Military Veterans: Etiology and Current Treatment Approaches
Kachadourian L, McCarthy E, Petrakis I. Alcohol Use Disorders and Comorbid Post-Traumatic Stress Disorder in US Military Veterans: Etiology and Current Treatment Approaches. 2016, 627-642. DOI: 10.1007/978-3-319-08359-9_108.ChaptersPost-traumatic stress disorderAlcohol use disorderComorbid post-traumatic stress disorderUse disordersAlcohol dependenceStress disorderCurrent treatment approachesSubstance use disordersUS military veteransPharmacological interventionsDual diagnosisTreatment approachesDisordersPotential mechanismsMilitary veteransHigh ratePsychotherapeutic approachesComorbiditiesEtiologyDiagnosis
2015
Alcohol Use Disorders and Comorbid Posttraumatic Stress Disorder in US Military Veterans: Etiology and Current Treatment Approaches
Kachadourian L, McCarthy E, Petrakis I. Alcohol Use Disorders and Comorbid Posttraumatic Stress Disorder in US Military Veterans: Etiology and Current Treatment Approaches. 2015, 1-13. DOI: 10.1007/978-3-319-08613-2_108-1.Peer-Reviewed Original ResearchAlcohol use disorderPosttraumatic stress disorderComorbid posttraumatic stress disorderUse disordersAlcohol dependenceStress disorderCurrent treatment approachesSubstance use disordersUS military veteransPharmacological interventionsDual diagnosisTreatment approachesDisordersPotential mechanismsMilitary veteransHigh ratePsychotherapeutic approachesComorbiditiesEtiologyDiagnosis
2013
Mecamylamine for Treatment of People With Dual Diagnoses of Depression and Alcohol Dependence
Ralevski E, Jane J, O’Brien E, Edens E, Arnaout B, Kerfoot K, Keegan K, Weiner J, Russo M, Petrakis I. Mecamylamine for Treatment of People With Dual Diagnoses of Depression and Alcohol Dependence. Journal Of Dual Diagnosis 2013, 9: 301-310. DOI: 10.1080/15504263.2013.835163.Peer-Reviewed Original ResearchDepressive symptomsAlcohol dependenceDual diagnosisRates of smokingMain outcome variablesSymptoms of depressionTreatment of peopleTreatment trialsComorbid depressionMecamylamineSide effectsNonsmokersSmokingSymptomsOutcome variablesBest treatmentDrinking outcomesDepressionPlaceboSmokersFurther studiesSignificant differencesDiagnosisParticipantsTreatmentPharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans
Arias A, Gelernter J, Gueorguieva R, Ralevski E, Petrakis I. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans. American Journal On Addictions 2013 DOI: 10.1111/j.1521-0391.2013.12102.x.Peer-Reviewed Original ResearchAllele carriersHeavy drinkingCo-occurring alcohol dependenceT allele carriersAlcohol-dependent subjectsAD treatment responseTreatment of individualsPrimary outcomePharmacogenetic interactionsHigher overall rateTreatment responseAxis INaltrexoneT carriersEuropean-American subjectsFavorable responseOPRM1 rs1799971More abstinenceAlcohol dependenceDependent subjectsDBH rs1611115DisulfiramGenotyped subjectsAbstinenceLess drinkingChapter 38 Disulfiram for Alcohol and Other Drug Use
Kerfoot K, Petrakis I. Chapter 38 Disulfiram for Alcohol and Other Drug Use. 2013, 367-374. DOI: 10.1016/b978-0-12-398338-1.00038-5.Peer-Reviewed Original ResearchUse disordersEfficacy of disulfiramAlcohol use disorderClinical research studiesCocaine use disorderDisulfiram useFirst medicationCardiorespiratory collapseIngested alcoholRare caseDrug AdministrationUS FoodDrug useAlcohol dependenceAddiction treatmentDisulfiramTreatmentNormal metabolismDisordersPositive outcomesPotential usefulnessNauseaMedicationsHeadacheAdministration
2012
Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence
Petrakis I, Ralevski E. Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence. 2012 DOI: 10.21236/ada568060.Peer-Reviewed Original ResearchAlpha-1 adrenergic receptor antagonistComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistAlcohol consumptionDouble-blind fashionCommon comorbid conditionsTreatment of patientsRates of PTSDCommon neurobiological mechanismsTraumatic Stress DisorderSymptoms of PTSDComorbid conditionsSleep disturbancesEffective treatmentGeneral populationTrauma nightmaresPrazosinCurrent diagnosisPatientsStress disorderNeurobiological mechanismsPTSD symptomsSymptoms
2011
Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence
Petrakis I. Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence. 2011 DOI: 10.21236/ada554540.Peer-Reviewed Original ResearchComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistSymptoms of PTSDAlcohol consumptionTraumatic Stress DisorderCommon neurobiological mechanismsDouble-blind fashionRates of PTSDTreatment of patientsPTSD symptomsStress disorderNeurobiological mechanismsCombat veteransPTSDCommon comorbidTrauma nightmaresSleep disturbancesEffective treatmentGeneral populationPrazosinCurrent diagnosisPatientsSymptomsErratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence
Krystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.Peer-Reviewed Original Research
2006
Effects of Naltrexone on Cognition in a Treatment Study of Patients with Schizophrenia and Comorbid Alcohol Dependence
Ralevski E, Balachandra K, Gueorguieva R, Limoncelli D, Petrakis I. Effects of Naltrexone on Cognition in a Treatment Study of Patients with Schizophrenia and Comorbid Alcohol Dependence. Journal Of Dual Diagnosis 2006, 2: 53-69. DOI: 10.1300/j374v02n04_05.Peer-Reviewed Original ResearchCognitive functioningAlcohol dependenceFrontal lobe functioningComorbid alcohol dependenceSymptoms of schizophreniaAlcohol useFunctioningCognitionTreatment studiesSchizophreniaEffects of naltrexoneAlcohol reductionMemoryDrinking patternsAlcohol consumptionAttentionSecond objectiveWeeks of treatmentDeficitsFirst objectiveWeek 24Naltrexone treatmentWeek 12NaltrexonePatients
2000
Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study
Boutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.Peer-Reviewed Original ResearchConceptsInformation processingCortical information processingSensory gatingPaired-click paradigmOlder healthy subjectsAlcohol dependenceSensory gating deficitsStimulus classificationNovel stimuliOddball paradigmHealthy individualsYoung healthy groupEvoked potential studiesDSM-IV criteriaPotential studiesHealthy subjectsGender-matched groupAged healthy individualsGender-matched healthy individualsGating deficitsMiddle-aged individualsPsychotic symptomsOlder groupProcessingAlcoholic patients