Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderTraumatic memoriesAutobiographical memoryNeural patternsIntersubject representational similarity analysisSimilar neural representationsRepresentational similarity analysisPosterior cingulate cortexTrauma memoriesMnemonic featuresNegative memoriesMultivoxel patternsNeural representationCognitive stateHippocampal representationsCognitive entitiesStress disorderCingulate cortexNeural activityTraumatic narrativesIndividual symptom severitySemantic representationMemory typesOwn memoryMemoryEvaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Ben-Zion Z, Spiller T, Keynan J, Admon R, Levy I, Liberzon I, Shalev A, Hendler T, Harpaz-Rotem I. Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. American Journal Of Psychiatry 2023, 180: 146-154. PMID: 36628514, PMCID: PMC9898083, DOI: 10.1176/appi.ajp.20220271.Peer-Reviewed Original ResearchConceptsPosttraumatic psychopathologyPsychiatric vulnerabilityGeneral hospital emergency departmentHospital emergency departmentRecent trauma survivorsAdditional replication studiesEmergency departmentObjective neural markersDifferent longitudinal patternsProspective symptomsMonths posttraumaAcute aftermathPsychiatric disordersEffective personalized treatmentTrauma exposureFunctional MRIPersonalized treatmentConsistent subgroupTreatment implicationsNeural activityAssessment 1Neural markersLongitudinal studyNeurobiological indicesDiagnostic methods