2024
Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder
Blithikioti C, Duek O, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. The Cerebellum 2024, 23: 2332-2340. PMID: 39180693, DOI: 10.1007/s12311-024-01731-9.Peer-Reviewed Original ResearchPost-traumatic stress disorderFunctional magnetic resonance imagingRight cerebellar lobule VICerebellar lobule VIAutobiographical memoryTraumatic eventsAutobiographical recallStress disorderLobule VIRe-experiencing of traumatic eventsChronic post-traumatic stress disorderDebilitating mental health conditionPTSD pathophysiologyProcessing negative emotionsNegative affective statesCerebellar Crus IIMental health conditionsCerebellar engagementRe-experiencingTrauma exposureCerebellar contributionReactivity paradigmNegative emotionsAffective statesCrus IISmaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.Peer-Reviewed Original Research
2023
Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderTraumatic memoriesAutobiographical memoryNeural patternsIntersubject representational similarity analysisSimilar neural representationsRepresentational similarity analysisPosterior cingulate cortexTrauma memoriesMnemonic featuresNegative memoriesMultivoxel patternsNeural representationCognitive stateHippocampal representationsCognitive entitiesStress disorderCingulate cortexNeural activityTraumatic narrativesIndividual symptom severitySemantic representationMemory typesOwn memoryMemoryExamining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abuseLong term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculusNeural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
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