Featured Publications
Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.Peer-Reviewed Original ResearchConceptsLung fibrosisDendritic cellsImmune cellsDiffuse cutaneous systemic sclerosisPersistence of fibrosisCutaneous systemic sclerosisExtent of fibrosisType I interferonSystemic sclerosisAutoimmune diseasesAntifibrotic targetsTherapeutic administrationMouse modelI interferonLung samplesLung explantsFibrosisFibrotic tissueImmune signalsEpiregulin expressionPatient's skinExtracellular matrix productionGenetic deficiencyEpiregulinEGFR ligands
2025
Engineering Mice to Study Human Immunity.
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025 PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Original ResearchHumanized miceHuman hematopoiesisImmune responseImmune systemHumanized mouse modelHuman hematopoietic stemImmunocompromised murine hostsResident immune cellsHuman immune responseStudy human immunityHuman immune systemIntegration of multi-omicsHematopoietic stemImmune cell growthImmune cellsEngineered miceProgenitor cellsMouse modelImmunological diseasesMurine hostCancer treatmentPreclinical drugsHuman immunityMiceModel diseaseAtgl-dependent adipocyte lipolysis promotes lipodystrophy and restrains fibrogenic responses during skin fibrosis
Caves E, Jussila A, Forni M, Benvie A, Lei V, King D, Edelman H, Hamdan M, Odell I, Hinchcliff M, Atit R, Horsley V. Atgl-dependent adipocyte lipolysis promotes lipodystrophy and restrains fibrogenic responses during skin fibrosis. Journal Of Investigative Dermatology 2025 PMID: 39884454, DOI: 10.1016/j.jid.2024.12.022.Peer-Reviewed Original ResearchLipid storageAdipocyte lipolysisExtracellular matrix proteinsFatty acidsTranscriptional analysisSkin fibrosisAdipocyte lipid storageTranscriptional changesSkin fibrosis developmentExtracellular matrix remodelingFibrosis developmentLipid-filled adipocytesDermal extracellular matrixHuman diseasesTreating fibrotic diseasesMouse modelMatrix proteinsDermal adipocytesFibrogenic responseGenetic modelsExtracellular matrixAdipocytesLoss of adipose tissueBleomycin-treated miceFibrotic mouse model
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