2012
Blastocystis–Host Interactions: Insights from In Vitro Model Systems
Tan K, Mirza H. Blastocystis–Host Interactions: Insights from In Vitro Model Systems. Parasitology Research Monographs 2012, 4: 51-63. DOI: 10.1007/978-3-642-32738-4_4.ChaptersIntra-subtype variationIntestinal epithelial cell lineHost immune responseProinflammatory cytokinesEpithelial cell lineINOS productionImmune responseBarrier compromiseVitro model systemAnimal modelsClinical relevanceBlastocystis subtypesCell linesPathogenesisVariety of effectsCell deathBlastocystisInsert systemParasitesCytokinesSubtypesImmunoglobulinPathobiology
2010
A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities
Mirza H, Teo JD, Upcroft J, Tan KS. A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities. Antimicrobial Agents And Chemotherapy 2010, 55: 637-648. PMID: 21098237, PMCID: PMC3028762, DOI: 10.1128/aac.00900-10.Peer-Reviewed Original ResearchConceptsTreatment failureBlastocystis infectionBlastocystis sppNew treatment optionsDrug-resistant isolatesStandard therapyTreatment regimensTreatment optionsMetronidazole resistanceControversial pathogenesisSubtype 4Drug susceptibilityImportant subtypeDrug sensitivitySubtypesStandard antimicrobialsInfectionZoonotic subtypesViability assaysPresent studyParasitesFirst studyCotrimoxazoleRegimensFailure
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