2025
Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
Maurer S, Hing B, Lussier S, Radhakrishna S, Davis J, Abbott P, Michaelson J, Stevens H. Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways. Journal Of Psychiatric Research 2025, 182: 149-160. PMID: 39809011, PMCID: PMC11959308, DOI: 10.1016/j.jpsychires.2024.12.048.Peer-Reviewed Original ResearchConceptsPrenatal stressAutism spectrum disorderSex-specific wayDorsal striatumNeurodevelopmental disordersGABAergic populationEffects of prenatal stressStriatal GABAergic neuronsReversal learningVentral forebrain regionsBrain changesSpectrum disorderForebrain regionsStriatal developmentGABAergic neuronsBehavioral assaysBrain developmentPlacental transcriptomeStriatumCognitionDevelopmental originsDisordersPlacental differencesPlacental functionPlacenta function
2024
Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress
da Cunha Menezes E, de Abreu F, Davis J, Maurer S, Roshko V, Richardson A, Dowell J, Cassella S, Stevens H. Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Developmental Biology 2024, 515: 112-120. PMID: 39048051, PMCID: PMC11330572, DOI: 10.1016/j.ydbio.2024.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell MovementFemaleGABAergic NeuronsGene Expression Regulation, DevelopmentalGlutamate DecarboxylaseGlutathione PeroxidaseGlutathione Peroxidase GPX1HypothyroidismMaleMethimazoleMiceNF-E2-Related Factor 2Oxidative StressPlacentaPregnancyPrenatal Exposure Delayed EffectsThyroid HormonesConceptsGestational hypothyroidismGABAergic system developmentMaternal thyroid hormone supplyThyroid hormone supplyCortical GABAergic interneuronsMaternal thyroid hormonesGene expressionCD-1 miceCentral nervous system developmentEmbryonic day 9Central nervous systemIntrauterine restrictionGABAergic interneuronsGABAergic systemGPx1 gene expressionBrain gene expressionMouse brain developmentCD-1HypothyroidismEmbryonic dayNervous system developmentThyroid hormonesRisk factorsNeural system developmentHormonal imbalance
2023
Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats
Wang H, Bullert A, Li X, Stevens H, Klingelhutz A, Ankrum J, Adamcakova-Dodd A, Thorne P, Lehmler H. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 2023, 500: 153677. PMID: 37995827, PMCID: PMC10757425, DOI: 10.1016/j.tox.2023.153677.Peer-Reviewed Original ResearchConceptsPersistent organic pollutantsPolychlorinated biphenylsPolymeric implantsDrug delivery systemsPCB 52Tandem mass spectrometryOrganic pollutantsMass spectrometryGas chromatographySustained releaseDelivery systemHuman metabolitesHole-board testAdolescent Sprague DawleyMale adolescent ratsAnxiety-like behaviorOpen field testLoading concentrationStraightforward methodHydroxylated metabolitesSubacute neurotoxicitySubacute exposureImmune inhibitionNeurotoxic outcomesSprague-Dawley
2012
Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex
Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology 2012, 38: 509-521. PMID: 22910687, PMCID: PMC3532962, DOI: 10.1016/j.psyneuen.2012.07.011.Peer-Reviewed Original ResearchLearning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
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