2025
Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
Maurer S, Hing B, Lussier S, Radhakrishna S, Davis J, Abbott P, Michaelson J, Stevens H. Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways. Journal Of Psychiatric Research 2025, 182: 149-160. PMID: 39809011, PMCID: PMC11959308, DOI: 10.1016/j.jpsychires.2024.12.048.Peer-Reviewed Original ResearchConceptsPrenatal stressAutism spectrum disorderSex-specific wayDorsal striatumNeurodevelopmental disordersGABAergic populationEffects of prenatal stressStriatal GABAergic neuronsReversal learningVentral forebrain regionsBrain changesSpectrum disorderForebrain regionsStriatal developmentGABAergic neuronsBehavioral assaysBrain developmentPlacental transcriptomeStriatumCognitionDevelopmental originsDisordersPlacental differencesPlacental functionPlacenta function
2024
Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome
Bullert A, Wang H, Linahon M, Chimenti M, Adamcakova-Dodd A, Li X, Dailey M, Klingelhutz A, Ankrum J, Stevens H, Thorne P, Lehmler H. Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome. Toxicology 2024, 509: 153965. PMID: 39369937, PMCID: PMC11588532, DOI: 10.1016/j.tox.2024.153965.Peer-Reviewed Original ResearchBehavior compared to controlsImpact locomotor activityFemale ratsPCB52 exposureNose-only inhalationWorking memoryBrains of femalesBehavioral effectsLocomotor activityMale Sprague-Dawley ratsMale ratsRat brainStriatumNeurobehavioral testsBrain transcriptomeCerebellar cortexSprague-Dawley ratsBrainConsecutive daysNo significant differenceImmunohistochemical evaluationRatsChromatography-tandem mass spectrometryTotal cellsSignificant difference
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