2024
A randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD
Sullivan A, Anderson J, Beatty M, Choi J, Jaccard J, Hawkins K, Pearlson G, Stevens M. A randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD. Behaviour Research And Therapy 2024, 181: 104615. PMID: 39173523, PMCID: PMC11465636, DOI: 10.1016/j.brat.2024.104615.Peer-Reviewed Original ResearchExecutive working memoryAttention-deficit/hyperactivity disorderWorking memory trainingMemory trainingExecutive working memory taskIncreased working memory capacityMedium effect size improvementsEffect size improvementsSelf-rated motivationIntervention participantsTarget engagementTrial retentionWorking memoryAttention-deficit/hyperactivityDifficulty manipulationPlacebo-controlled studyMemory capacityTask accuracySize improvementsMemory contentIntervention tolerabilityTraining targetBehavioral changesPrimary outcome measureCoaching sessions75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder
Beatty M, Sullivan A, Anderson J, Choi J, Pearlson G, Hawkins K, Bond D, Stevens M. 75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder. Biological Psychiatry 2024, 95: s130. DOI: 10.1016/j.biopsych.2024.02.310.Peer-Reviewed Original Research73. Preliminary Efficacy Findings for a Placebo Controlled Randomized Clinical Trial of a Novel Executive Working Memory Training Intervention for Adolescents With ADHD
Sullivan A, Anderson J, Beatty M, Choi J, Jaccard J, Pearlson G, Stevens M. 73. Preliminary Efficacy Findings for a Placebo Controlled Randomized Clinical Trial of a Novel Executive Working Memory Training Intervention for Adolescents With ADHD. Biological Psychiatry 2024, 95: s129. DOI: 10.1016/j.biopsych.2024.02.308.Peer-Reviewed Original Research74. Functional Connectivity Changes as a Result of a Novel Executive Working Memory Training in Adolescents With ADHD
Sullivan A, Anderson J, Beatty M, Choi J, Jaccard J, Pearlson G, Stevens M. 74. Functional Connectivity Changes as a Result of a Novel Executive Working Memory Training in Adolescents With ADHD. Biological Psychiatry 2024, 95: s129-s130. DOI: 10.1016/j.biopsych.2024.02.309.Peer-Reviewed Original Research287. Younger Versus Older Adolescent Brains With Different Cognitive Reappraisal Styles Regulate Their Emotional Intensity in Different Ways
Stevens M, Novotny S, Pearlson G. 287. Younger Versus Older Adolescent Brains With Different Cognitive Reappraisal Styles Regulate Their Emotional Intensity in Different Ways. Biological Psychiatry 2024, 95: s217. DOI: 10.1016/j.biopsych.2024.02.786.Peer-Reviewed Original Research
2023
Estradiol effects on an emotional interference task in adolescents with current and remitted depression
Sullivan A, Chung Y, Novotny S, Epperson C, Kober H, Blumberg H, Gross J, Ochsner K, Pearlson G, Stevens M. Estradiol effects on an emotional interference task in adolescents with current and remitted depression. Hormones And Behavior 2023, 157: 105450. PMID: 37923628, PMCID: PMC10842169, DOI: 10.1016/j.yhbeh.2023.105450.Peer-Reviewed Original ResearchAttentional biasesFacial expressionsAdolescent femalesRemitted depressionEmotional facial expressionsNeutral facial expressionsEmotional interference taskAttention capture effectsMajor depressive disorderMDD groupResponse reaction timesGroups of participantsMain effectHappy stimuliInterference taskEmotional stimuliEmotional contentAI scoreControl adolescentsDisorder onsetInterference scoresGroup interactionMDD adolescentsSex hormone estradiolAdolescentsAge-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associations
2022
P436. Multivariate Associations Between White Matter Microstructure Development and Normative Gains in Three Executive Function Domains
Anderson J, Hawkins K, Pearlson G, Stevens M. P436. Multivariate Associations Between White Matter Microstructure Development and Normative Gains in Three Executive Function Domains. Biological Psychiatry 2022, 91: s264. DOI: 10.1016/j.biopsych.2022.02.672.Peer-Reviewed Original ResearchAcute cannabis-related alterations in an fMRI time estimation task
Patel K, Stevens M, Adhikari S, Book G, Mubeen M, Pearlson G. Acute cannabis-related alterations in an fMRI time estimation task. 2022 DOI: 10.26828/cannabis.2022.02.000.26.Peer-Reviewed Original ResearchMedial temporal cortexPosterior cingulate cortexSomatosensory motor cortexPremotor cortexMotor cortexTemporal cortexMedial prefrontal cortexCingulate cortexFrontal cortexLong-duration stimuliAnterior cingulateInferior frontal cortexVisual cortexBrain activation differencesMultiple comparison correctionPlacebo conditionActivation differencesDuration stimuliPrefrontal cortexVisual areasOccipital junctionDose-related mannerMid-cingulate cortexSignificant activation differencesPopular recreational drug
2021
Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder
Balodis I, Linnet J, Arshad F, Worhunsky P, Stevens M, Pearlson G, Potenza M. Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder. 2021, 97-113. DOI: 10.4324/9781003140450-7.ChaptersMonetary incentive delay taskIowa Gambling TaskIncentive delay taskGambling disorderAnticipatory processingIGT scoresIGT performanceDelay taskIowa Gambling Task performanceProspect of rewardDecision-making impairmentsGambling Task performanceVentromedial prefrontal cortexDecision-making taskWhole-brain correlationFronto-striatal activityHC groupVentral striatum/Healthy control participantsTotal IGT scoreAnterior cingulate regionsGambling TaskNeural processesNeural processingTask performanceResponse Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity
Steele V, Tootell A, Butler D, Fix S, Stevens M, Pearlson G, Bernat E. Response Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity. Biological Psychiatry 2021, 89: s350. DOI: 10.1016/j.biopsych.2021.02.873.Peer-Reviewed Original ResearchLongitudinal Effects of Acute Cannabis Exposure on Automobile Driving Behavior in a Naturalistic Simulated Environment
Meda S, Boer E, Ward N, Book G, Stevens M, Boyle C, Mubeen M, Pearlson G. Longitudinal Effects of Acute Cannabis Exposure on Automobile Driving Behavior in a Naturalistic Simulated Environment. 2021 DOI: 10.26828/cannabis.2021.01.000.21.Peer-Reviewed Original ResearchAcute cannabis exposureHigh-dose subjectsDrug dose levelsSignificant public health riskCannabis exposureDose studyDrug exposureSimulated environmentInfluence of cannabisSafe overtakingSingle acuteHigh doseSPSS v24Psychomotor functionComplex dayDriving functionsDose levelsHigh dosesSeparate daysPublic health riskOverall riskIntoxicated subjectsDoseThree timesNumerous metrics
2020
Neural Correlates of Non-Specific Skin Conductance Responses During Resting State fMRI
Gertler J, Novotny S, Poppe A, Chung Y, Gross J, Pearlson G, Stevens M. Neural Correlates of Non-Specific Skin Conductance Responses During Resting State fMRI. Biological Psychiatry 2020, 87: s313. DOI: 10.1016/j.biopsych.2020.02.805.Peer-Reviewed Original Research
2019
O13.8. TEEN PSYCHOSIS AND SUICIDE
Graham P, Deasy M, Tolin D, Haber L, Zajac J, Stevens M, Pearlson G, Choi J. O13.8. TEEN PSYCHOSIS AND SUICIDE. Schizophrenia Bulletin 2019, 45: s203-s203. PMCID: PMC6455400, DOI: 10.1093/schbul/sbz021.280.Peer-Reviewed Original Research11.2 PUPILLOMETER-BASED NEUROFEEDBACK COGNITIVE TRAINING: OPTIMIZING TASK ENGAGEMENT TO ENHANCE LEARNING IN PRODROME, FIRST EPISODE, AND ESTABLISHED PSYCHOSIS
Choi J, Fiszdon J, Stevens M, Haber L, Pearlson G. 11.2 PUPILLOMETER-BASED NEUROFEEDBACK COGNITIVE TRAINING: OPTIMIZING TASK ENGAGEMENT TO ENHANCE LEARNING IN PRODROME, FIRST EPISODE, AND ESTABLISHED PSYCHOSIS. Schizophrenia Bulletin 2019, 45: s104-s105. PMCID: PMC6455325, DOI: 10.1093/schbul/sbz022.040.Peer-Reviewed Original Research
2017
959 Inferring Pathobiology from Structural MRI in Schizophrenia and Bipolar Disorder: Modeling Head Motion and Neuroanatomical Specificity
Glahn D, Yao N, Winkler A, Barrett J, Book G, Beetham T, Horseman R, Leach O, Hodgson K, Knowles E, Mathias S, Stevens M, Assaf M, van Erp T, Pearlson G. 959 Inferring Pathobiology from Structural MRI in Schizophrenia and Bipolar Disorder: Modeling Head Motion and Neuroanatomical Specificity. Biological Psychiatry 2017, 81: s388. DOI: 10.1016/j.biopsych.2017.02.685.Peer-Reviewed Original Research
2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorder
2012
Erratum to “A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's Disease in the ADNI cohort” [Neuroimage 60/3(2012) 1608–1621]
Meda S, Narayanan B, Liu J, Perrone-Bizzozero N, Stevens M, Calhoun V, Glahn D, Shen L, Risacher S, Saykin A, Pearlson G. Erratum to “A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's Disease in the ADNI cohort” [Neuroimage 60/3(2012) 1608–1621]. NeuroImage 2012, 62: 2177. DOI: 10.1016/j.neuroimage.2012.03.058.Peer-Reviewed Original Research
2010
P2‐396: Changes in brain connectivity in aging and mild cognitive impairment, investigated with diffusion tensor imaging and resting state MRI
Skudlarski P, Skudlarska B, Stevens M, Pearlson G. P2‐396: Changes in brain connectivity in aging and mild cognitive impairment, investigated with diffusion tensor imaging and resting state MRI. Alzheimer's & Dementia 2010, 6: s433-s434. DOI: 10.1016/j.jalz.2010.05.1448.Peer-Reviewed Original Research
2009
Pharmacological Manipulations of “Resting State” Brain Function using Alcohol and Marijuana
Turner B, Meda, Ruopp K, Stevens M, Pearlson G. Pharmacological Manipulations of “Resting State” Brain Function using Alcohol and Marijuana. NeuroImage 2009, 47: s186. DOI: 10.1016/s1053-8119(09)72069-5.Peer-Reviewed Original Research
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