Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations
Xia C, Alliey-Rodriguez N, Tamminga C, Keshavan M, Pearlson G, Keedy S, Clementz B, McDowell J, Parker D, Lencer R, Hill S, Bishop J, Ivleva E, Wen C, Dai R, Chen C, Liu C, Gershon E. Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations. Molecular Psychiatry 2024, 1-13. PMID: 39709506, DOI: 10.1038/s41380-024-02876-z.Peer-Reviewed Original ResearchTranscriptome-wide association studyPolygenic risk scoresNeural cell adhesion molecule 1Genomic associationsGenetically regulated expressionPolygenic risk score analysisMendelian randomizationGenotype principal componentsNeurite out-growthGenomic analysisAssociation studiesSchizophrenia polygenic risk scoresAssociation analysisNCAM signalingBiological pathwaysGenesIntermediate phenotypesBiotypesPolygenic riskCell adhesion molecule 1Bipolar-Schizophrenia NetworkDiagnosis of schizophreniaOut-growthRisk scoreBiological investigationsW74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS
Xia C, Alliey-Rodriguez N, Tamminga C, Keshavan M, Pearlson G, Keedy S, Parker D, Bishop J, Chen C, Liu C, Gershon E. W74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS. European Neuropsychopharmacology 2024, 87: 141-142. DOI: 10.1016/j.euroneuro.2024.08.283.Peer-Reviewed Original ResearchTranscriptome-wide association studyGenome-wide complex trait analysisPotential causal genesQuantitative Trait LociRisk genesEvent-related potentialsPolygenic risk scoresIntermediate phenotypesGene OntologyCase-control statusPsychotic disordersComplex trait analysisGenotype principal componentsIdentified risk genesGenetic correlationsMulti-omics analysisMendelian randomizationPRS-CSxPsychosis risk genesCausal genesAssociation studiesGenomic characteristicsDetect significant associationsGene associationsBipolar-Schizophrenia Network
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