2025
Artificial intelligence-assisted detection of nasopharyngeal carcinoma on endoscopic images: a national, multicentre, model development and validation study
Shi Y, Li Z, Wang L, Wang H, Liu X, Gu D, Chen X, Liu X, Gong W, Jiang X, Li W, Lin Y, Liu K, Luo D, Peng T, Peng X, Tong M, Zheng H, Zhou X, Wu J, El Fakhri G, Chang M, Liao J, Li J, Wang D, Ye J, Qu S, Jiang W, Liu Q, Sun X, Zheng Y, Yu H. Artificial intelligence-assisted detection of nasopharyngeal carcinoma on endoscopic images: a national, multicentre, model development and validation study. The Lancet Digital Health 2025, 100869. PMID: 40544083, DOI: 10.1016/j.landig.2025.03.001.Peer-Reviewed Original ResearchArea under the curveNasopharyngeal carcinomaEndoscopic imagesReal-world environmentDeep learning algorithmsDeep learning systemBenign hyperplasiaNormal nasopharynxShanghai Municipal Key Clinical SpecialtyLearning algorithmsMalignant imagesSkull base tumorsDetection of nasopharyngeal carcinomaLearning systemAI modelsIncidence of nasopharyngeal carcinomaPrimary hospitalsDiagnostic capabilitiesNasopharyngeal carcinoma diagnosisDiagnostic challengeImaging manifestationsCarcinoma diagnosisCarcinomaDiagnostic accuracyEndoscopic examinationUltrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging
Zhao Y, Li Y, Jin W, Guo R, Ma C, Tang W, Li Y, El Fakhri G, Liang Z. Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging. Nature Biomedical Engineering 2025, 1-13. PMID: 40542105, DOI: 10.1038/s41551-025-01418-4.Peer-Reviewed Original ResearchSpectroscopic imagingLong data acquisition timesData acquisition timeJ-coupling informationMagnetic resonance spectroscopic imagingPhantom experimentsPoor spatial resolutionJ-couplingLabel-free metabolic imagingNon-invasive metabolic imagingSpatial resolutionAcquisition timeMetabolic imagingPhantomData acquisitionHuman brainPhysics-informed machine learningMetabolic brain imagingA Cross-Modality Transformer Network for MR-Guided Low-dose Tau PET Image Denoising
Jang S, Gomez C, Becker A, Thibault E, Price J, Johnson K, Fakhri G, Gong K. A Cross-Modality Transformer Network for MR-Guided Low-dose Tau PET Image Denoising. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. DOI: 10.1109/trpms.2025.3581204.Peer-Reviewed Original ResearchQuantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240.
Xia Y, Dhaynaut M, Chemli Y, Lois C, Hanseeuw B, Thibault E, Groot C, Ossenkoppele R, Johnson K, El Fakhri G, Normandin M, Guehl N. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240. Journal Of Nuclear Medicine 2025, jnumed.125.270165. PMID: 40533354, DOI: 10.2967/jnumed.125.270165.Peer-Reviewed Original ResearchModeling inter‐reader variability in clinical target volume delineation for soft tissue sarcomas using diffusion model
Dong Y, Marin T, Zhuo Y, Najem E, Beddok A, Rozenblum L, Moteabbed M, Grogg K, Xing F, Woo J, Chen Y, Lim R, Liu X, Ma C, Fakhri G. Modeling inter‐reader variability in clinical target volume delineation for soft tissue sarcomas using diffusion model. Medical Physics 2025 PMID: 40317577, DOI: 10.1002/mp.17865.Peer-Reviewed Original ResearchClinical target volumeGross tumor volumeClinical target volume delineationSoft tissue sarcomasInter-reader variabilityTissue sarcomasClinical target volume contoursMagnetic resonance imagingCTV delineationTarget volume delineationComputed tomographyTreatment of soft tissue sarcomasFluorodeoxyglucose positron emission tomographyCTV contoursTarget volumeVolume delineationT1-weighted magnetic resonance imagingRadiotherapy treatmentEnergy distanceHigh Dice indexPositron emission tomographyTumor volumeMicroscopic spreadFDG-PETTreatment planning3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy
Jee K, Bijari F, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kang J, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G. 3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy. Radiotherapy And Oncology 2025, 206: s3543-s3544. DOI: 10.1016/s0167-8140(25)01927-9.Peer-Reviewed Original Research273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation
Dan R, Borchers L, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, Fakhri G, Normandin M, Pizzagalli D. 273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation. Biological Psychiatry 2025, 97: s208. DOI: 10.1016/j.biopsych.2025.02.511.Peer-Reviewed Original Research1238 Machine Learning Prediction of Secondary Recurrence in Head and Neck Cancer after Reirradiation Using a Weighted Average Model on Pre-reRT PET Imaging
Colson B, Regnault P, Kraus V, Buvat I, Calugaru V, Crehange G, Fakhri G, Passat N, Beddok A. 1238 Machine Learning Prediction of Secondary Recurrence in Head and Neck Cancer after Reirradiation Using a Weighted Average Model on Pre-reRT PET Imaging. Radiotherapy And Oncology 2025, 206: s963-s965. DOI: 10.1016/s0167-8140(25)00349-4.Peer-Reviewed Original ResearchElevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study
Salardini A, Himali J, Abdullah M, Chaudhari R, Young V, Zilli E, McGrath E, Gonzales M, Thibault E, Salinas J, Aparicio H, Himali D, Ghosh S, Buckley R, Satizabal C, Johnson K, DeCarli C, Fakhri G, Vasan R, Beiser A, Seshadri S. Elevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2025, 21: e70179. PMID: 40271551, PMCID: PMC12019305, DOI: 10.1002/alz.70179.Peer-Reviewed Original ResearchConceptsPost-menopausal womenFramingham Heart Study participantsIncreased risk of ADFramingham Heart StudyRisk of ADNo significant associationHeart StudyEarly risk factorsStudy participantsMenopausal statusMultivariate regression analysisApolipoprotein E4Significant associationAlzheimer's diseaseIncreased riskRisk factorsCognitive impairmentMenopausal womenBrain amyloid depositionRegression analysisWomenAnalyzed dataPositron emission tomographyIncreased amyloid depositionBurdenDual Prompting for Diverse Count-Level Pet Denoising
Liu X, Huang Y, Marin T, Chemli Y, Eslahi S, Tiss A, Johnson K, Fakhri G, Ouyang J. Dual Prompting for Diverse Count-Level Pet Denoising. 2025, 00: 1-5. DOI: 10.1109/isbi60581.2025.10980695.Peer-Reviewed Original ResearchOverall Survival Prediction of Brain Tumor Patients with Multimodal MRI using Swin Unetr
Kim G, Xing F, Kong H, Santarnecchi E, Shih H, Bortfeld T, Fakhri G, Liu X, Choi J, Woo J. Overall Survival Prediction of Brain Tumor Patients with Multimodal MRI using Swin Unetr. 2025, 00: 1-5. DOI: 10.1109/isbi60581.2025.10981128.Peer-Reviewed Original ResearchMultimodal magnetic resonance imagingBrain tumor patientsGlioblastoma patient survivalPersonalized treatment plansSurvival prediction performanceMultimodal MRIOverall survival predictionMagnetic resonance imagingHand-crafted featuresState-of-the-artMulti-scale featuresMulti-task frameworkPatient survivalClinical prognosisTumor patientsGlioblastoma patientsSuperior segmentation accuracyTreatment planningResonance imagingSurvival prediction taskPredictive performanceSurvival predictionPrediction taskBraTS datasetSurvivalFair text to medical image diffusion model with subgroup distribution aligned tuning
Han X, Fan F, Rong J, Li Z, Fakhri G, Chen Q, Liu X. Fair text to medical image diffusion model with subgroup distribution aligned tuning. Progress In Biomedical Optics And Imaging 2025, 13411: 1341113-1341113-5. DOI: 10.1117/12.3046450.Peer-Reviewed Original ResearchContrastive Language-Image Pre-trainingMedical imagesDistribution alignment methodsKnowledge distillation frameworkImage synthesis modelMedical image dataGender classifierDistillation frameworkAlignment lossRegularization termApplication datasetsTarget datasetRepresentation inconsistenciesAppearance distributionsPre-trainingTraining datasetClassification probabilitiesBrain magnetic resonanceFine-tuningDatasetStatus descriptionBraTS18Image dataClassifierEvaluation purposesContrast-enhanced image-guided learning for nasopharyngeal carcinoma diagnosis using non-contrast MRI
Li Z, Shi Y, Liu X, Wang L, Woo J, Ouyang J, El Fakhri G, Yu H, Liu X. Contrast-enhanced image-guided learning for nasopharyngeal carcinoma diagnosis using non-contrast MRI. 2025, 11. DOI: 10.1117/12.3046863.Peer-Reviewed Original ResearchPO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY
Kang J, Bijari F, Jee K, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Fakhri G, Levine R, Lehmann H. PO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY. Heart Rhythm 2025, 22: s484. DOI: 10.1016/j.hrthm.2025.03.1230.Peer-Reviewed Original ResearchOptimizing imaging modalities for sarcoma subtypes in radiation therapy: State of the art
Beddok A, Kaur H, Khurana S, Dercle L, El Ayachi R, Jouglar E, Mammar H, Mahe M, Najem E, Rozenblum L, Thariat J, El Fakhri G, Helfre S. Optimizing imaging modalities for sarcoma subtypes in radiation therapy: State of the art. Critical Reviews In Oncology/Hematology 2025, 211: 104708. PMID: 40139581, DOI: 10.1016/j.critrevonc.2025.104708.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingRadiation therapyComputed tomographyRT planningImaging modalitiesSarcoma managementSarcoma subtypesAssessment of tumor extentIntegration of magnetic resonance imagingAlveolar soft part sarcomaSuperior soft tissue contrastSoft part sarcomaCombination of magnetic resonance imagingContext of radiation therapyIntegration of imaging modalitiesMetabolically active regionsActive regionPositron emission tomographyRT deliveryDose escalationSoft tissue contrastUterine sarcomaTumor extentTumor marginsOsseous involvementFlexible and modular PET: Evaluating the potential of TOF‐DOI panel detectors
Razdevšek G, Fakhri G, Marin T, Dolenec R, Orehar M, Chemli Y, Gola A, Gascon D, Majewski S, Pestotnik R. Flexible and modular PET: Evaluating the potential of TOF‐DOI panel detectors. Medical Physics 2025, 52: 2845-2860. PMID: 40089973, PMCID: PMC12059530, DOI: 10.1002/mp.17741.Peer-Reviewed Original ResearchDepth of interactionLong axial field-of-viewTime-of-flightPanel detectorHigh-performance computing clusterDepth-of-interaction resolutionNoise equivalent count rateDepth-of-interaction capabilityDepth-of-interaction detectorsAxial field-of-viewImage qualityTime-of-Flight (TOFDistortion-free imagesPositron emission tomography scannerLong axial fieldComputer clusterSpatial resolutionLSO crystalsImage reconstructionDetector materialCount rateGATE softwareContrast-to-noise ratioParallax errorMonte Carlo simulationsPET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction. IEEE Transactions On Biomedical Engineering 2025, 72: 1057-1066. PMID: 39446540, PMCID: PMC11875991, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugs[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original ResearchComputational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, 66: 509-515. PMID: 39947910, PMCID: PMC11960611, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokineticsComputational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
Strigari L, Schwarz J, Bradshaw T, Brosch-Lenz J, Currie G, El-Fakhri G, Jha A, Mežinska S, Pandit-Taskar N, Roncali E, Shi K, Uribe C, Yusufaly T, Zaidi H, Rahmim A, Saboury B. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins. Journal Of Nuclear Medicine 2025, 66: jnumed.124.268186. PMID: 39848769, PMCID: PMC12051771, DOI: 10.2967/jnumed.124.268186.Peer-Reviewed Original ResearchRadiopharmaceutical therapyNuclear oncologySociety of Nuclear MedicinePredictive dosimetryDosimetric informationTreatment planningTreatment outcomesLack of reimbursementTreatment personalizationDose responseTreatment optimizationEtiological mechanismsRobust security measuresPatient consentReal-world systemsNuclear medicineCross-border data sharingPatientsTreatmentEthical approval
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