Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort
Gonzales M, O’Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort. Alzheimer's & Dementia 2024, 20: e087431. PMCID: PMC11716433, DOI: 10.1002/alz.087431.Peer-Reviewed Original ResearchStratified analysisPoorer visuospatial functionFramingham Heart StudyTau positron emission tomographyPositron emission tomographyMiddle-aged cohortApolipoprotein E4 statusCommunity-based cohortTau accumulationAssociated with cognitive declineVisuospatial functionLow cognitive reserveAssociated with cognitionAmyloid-betaHeart StudyOlder adultsE4 statusLinear regression modelsCerebral amyloid-betaPoor cognitionMeasures of ABCognitive AssessmentCollege degreeCognitive reserveMidlife
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