2025
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories
Yusufaly T, Roncali E, Brosch-Lenz J, Uribe C, Jha A, Currie G, Dutta J, El-Fakhri G, McMeekin H, Pandit-Taskar N, Schwartz J, Shi K, Strigari L, Zaidi H, Saboury B, Rahmim A. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories. Journal Of Nuclear Medicine 2025, 66: 509-515. PMID: 39947910, PMCID: PMC11960611, DOI: 10.2967/jnumed.124.267927.Peer-Reviewed Original ResearchRadiopharmaceutical therapyImage-based dosimetryPrediction of doseInternal dosimetryPersonalized treatment plansMetastatic diseaseDosimetryNuclear oncologyClinical outcomesNuclear medicineClinical endpointsTreatment planningOncology communityDose responseEtiological mechanismsTargeted deliveryRadiobiologyRadiotherapyMalignancyRadiationLong-termTherapyPharmacotherapyDoseRadiopharmacokineticsComputational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
Strigari L, Schwarz J, Bradshaw T, Brosch-Lenz J, Currie G, El-Fakhri G, Jha A, MeĹľinska S, Pandit-Taskar N, Roncali E, Shi K, Uribe C, Yusufaly T, Zaidi H, Rahmim A, Saboury B. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins. Journal Of Nuclear Medicine 2025, 66: jnumed.124.268186. PMID: 39848769, PMCID: PMC12051771, DOI: 10.2967/jnumed.124.268186.Peer-Reviewed Original ResearchRadiopharmaceutical therapyNuclear oncologySociety of Nuclear MedicinePredictive dosimetryDosimetric informationTreatment planningTreatment outcomesLack of reimbursementTreatment personalizationDose responseTreatment optimizationEtiological mechanismsRobust security measuresPatient consentReal-world systemsNuclear medicineCross-border data sharingPatientsTreatmentEthical approval
2014
Physical Aspects of Pediatric Nuclear Medicine Imaging
Fahey F, Lim R, El-Fakhri G. Physical Aspects of Pediatric Nuclear Medicine Imaging. 2014, 621-643. DOI: 10.1007/978-1-4614-9551-2_27.Peer-Reviewed Original ResearchNuclear medicine imagingReduction of radiation doseMedicine imagingQuality of nuclear medicine imagingNuclear medicine studiesApplications of nuclear medicineClinical resultsRadiation doseImage quality improvementTomographic reconstructionHybrid imagingMedicine studiesPatientsNuclear medicineChildrenReconstruction technique
2005
Collimator Optimization for Detection and Quantitation Tasks: Application to Gallium-67 Imaging
Moore S, Kijewski M, Fakhri G. Collimator Optimization for Detection and Quantitation Tasks: Application to Gallium-67 Imaging. IEEE Transactions On Medical Imaging 2005, 24: 1347-1356. PMID: 16229420, DOI: 10.1109/tmi.2005.857211.Peer-Reviewed Original ResearchMeSH KeywordsCitratesComputer SimulationComputer-Aided DesignEquipment DesignEquipment Failure AnalysisGalliumHumansImage EnhancementImage Interpretation, Computer-AssistedModels, BiologicalNeoplasmsPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityConceptsMedium-energy low-penetration collimatorCollimator optimizationGeometric spatial resolutionPhotopeak energy windowSimulation of photon transportLead X-raysClinical imaging tasksActivity estimation taskSignal-to-noise ratioGallium-67 imagingContaminating photonsEnergy windowGeometric efficiencyCollimator designFixed energyPhoton transportOptimal collimatorCollimatorHotelling observerFWHMSpatial resolutionNuclear medicineDetectorResolution valuesImaging tasks
2002
Optimal Parallel-Hole Collimation for Lesion Detection and Activity Estimation in Ga-67 Imaging
Moore S, Kijewski M, Fakhri G. Optimal Parallel-Hole Collimation for Lesion Detection and Activity Estimation in Ga-67 Imaging. 2002, 3: 1390-1392. DOI: 10.1109/nssmic.2002.1239580.Peer-Reviewed Original ResearchCollimator designMedium-energy (MESimulation of photon transportSignal-to-noise ratioParallel-hole collimatorDesign of collimatorsClinical imaging tasksGa-67Contaminating photonsField of nuclear medicineEnergy windowFixed energyPhoton transportOptimal collimatorCollimatorCommercial collimatorsStaging of lymphoma patientsHotelling observerGa-67 imagingNuclear medicine clinicsLesion detectionNuclear medicineDetectorActivity concentrationsResolution values
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