2024
Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort
Gonzales M, O’Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort. Alzheimer's & Dementia 2024, 20: e087431. PMCID: PMC11716433, DOI: 10.1002/alz.087431.Peer-Reviewed Original ResearchStratified analysisPoorer visuospatial functionFramingham Heart StudyTau positron emission tomographyPositron emission tomographyMiddle-aged cohortApolipoprotein E4 statusCommunity-based cohortTau accumulationAssociated with cognitive declineVisuospatial functionLow cognitive reserveAssociated with cognitionAmyloid-betaHeart StudyOlder adultsE4 statusLinear regression modelsCerebral amyloid-betaPoor cognitionMeasures of ABCognitive AssessmentCollege degreeCognitive reserveMidlife
2021
Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
Sprugnoli G, Munsch F, Cappon D, Paciorek R, Macone J, Connor A, El Fakhri G, Salvador R, Ruffini G, Donohoe K, Shafi M, Press D, Alsop D, Pascual Leone A, Santarnecchi E. Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease. Alzheimer's Research & Therapy 2021, 13: 203. PMID: 34930421, PMCID: PMC8690894, DOI: 10.1186/s13195-021-00922-4.Peer-Reviewed Original ResearchConceptsTemporal lobeMethodsIn two open-label studiesMild to moderate AD participantsPreclinical models of ADGamma bandBrain oscillatory activityModerate AD participantsBilateral temporal lobesEpisodic memoryAdministered 1 hSpectral power changesBrain areasModulates cerebral perfusionAD participantsPlacebo-controlled trialHippocampal perfusionModel of ADOpen-label studyNeural activityAssociated with alterationsNon-invasive countermeasureCognitive AssessmentCognitive impairmentCognitive protectionOscillatory activity
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply