1990
Inhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies
Orlowski R, Polvino-Bodnar M, Hearing J, Miller G. Inhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies. Virology 1990, 176: 638-642. PMID: 2161154, DOI: 10.1016/0042-6822(90)90036-q.Peer-Reviewed Original ResearchConceptsEBNA-1 proteinGel mobility shift experimentsMobility shift experimentsSequence-specific DNARecognition of DNAEBNA-1Binding of DNASpecific bindingLac promoterDNA bindingMonoclonal antibodiesDimerization siteSpecific DNANonfusion proteinBurkitt's lymphoma cellsShift experimentsMolecular massEscherichia coliProteinDNASame monoclonal antibodyBindingPolyclonal antibodiesEB virusLymphoma cells
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigenAn identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed
Miller G, Sugden B. An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed. Virology 1985, 143: 478-484. PMID: 2998023, DOI: 10.1016/0042-6822(85)90387-3.Peer-Reviewed Original Research
1983
Central-Nervous-System Lymphoma Related to Epstein–Barr Virus
Hochberg F, Miller G, Schooley R, Hirsch M, Feorino P, Henle W. Central-Nervous-System Lymphoma Related to Epstein–Barr Virus. New England Journal Of Medicine 1983, 309: 745-748. PMID: 6310394, DOI: 10.1056/nejm198309293091301.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralBrain NeoplasmsBurkitt LymphomaDNA, NeoplasmFemaleGenes, ViralHerpesvirus 4, HumanHumansMaleMiddle AgedConceptsEpstein-Barr virusCentral nervous systemSystem lymphomaPrimary lymphomaNervous systemEpstein-Barr virus-specific antibodiesEpstein-Barr virus infectionEpstein-Barr virus genomeRecent primary infectionAdjacent normal brain tissueVirus-specific antibodiesNormal brain tissueSystemic lymphomaBamHI K fragmentAdditional patientsSerologic evidenceOngoing infectionPrimary infectionVirus infectionLymphomaBrain tissueTumor tissueSerum samplesInfectionVirus
1982
Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody
Miller G, Heston L, Hoffman G. Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody. Infection And Immunity 1982, 37: 1028-1031. PMID: 6182100, PMCID: PMC347642, DOI: 10.1128/iai.37.3.1028-1031.1982.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMurine monoclonal antibodiesMonoclonal antibodiesCases of mononucleosisB95-8 strainBurkitt's lymphoma cell linesPolyclonal lymphomaBlood transfusionEBV strainsAmerican patientsChallenge virusLymphoma cell linesBurkitt's lymphomaLymphocyte immortalizationAfrican childrenHybridoma antibodiesAntigenic differencesAntibodiesMarmoset cellsMononucleosisVirusAntigenic sitesCell linesLymphomaAntigenNew Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
Heston L, Rabson M, Brown N, Miller G. New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 1982, 295: 160-163. PMID: 6276755, DOI: 10.1038/295160a0.Peer-Reviewed Original Research
1981
Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates
Fischer D, Miller G, Gradoville L, Heston L, Weststrate M, Maris W, Wright J, Brandsma J, Summers W. Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates. Cell 1981, 24: 543-553. PMID: 6263500, DOI: 10.1016/0092-8674(81)90345-7.Peer-Reviewed Original ResearchMeSH KeywordsBurkitt LymphomaDNA Restriction EnzymesDNA, ViralGenes, ViralHerpesvirus 4, HumanInfectious MononucleosisSalivaSpecies SpecificityConceptsBurkitt's lymphomaB95-8Infectious mononucleosisUncomplicated infectious mononucleosisEpstein-Barr virusSalivary isolatesEBV infectionDisease manifestationsLymphomaMononucleosisPatientsEBVRestriction enzyme analysisVirusMajor insertionC fragmentEnzyme analysisHr-1IsolatesInfectionDeletionAvailable virus
1979
Cross-neutralization of infectious mononucleosis and Burkitt lymphoma strains of Epstein-Barr virus with hyperimmune rabbit antisera.
Coope D, Heston L, Brandsma J, Miller G. Cross-neutralization of infectious mononucleosis and Burkitt lymphoma strains of Epstein-Barr virus with hyperimmune rabbit antisera. The Journal Of Immunology 1979, 123: 232-8. PMID: 221591, DOI: 10.4049/jimmunol.123.1.232.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell linesMarmoset lymphoblastoid cell lineHuman B lymphoid cellsHR-1 strainDiverse biologic propertiesSource of antigenLymphoblastoid T-cell lineCross-absorption testsT cell linesSera of rabbitsB-lymphoid cellsInhibition of inductionVirus producer cellsImmunization of rabbitsInfectious mononucleosisSupernatant culture fluidsEB virusEarly antigenHyperimmune rabbit antiserumAntibody titersInhibition of transformationLymphoblastoid cell linesLymphoid cellsNormal lymphocytes
1975
Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference.
Miller G, Robinson J, Heston L, Lipman M. Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference. IARC Scientific Publications 1975, 395-408. PMID: 190145.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumPretreatment of lymphocytesNon-producer cell linesCell linesHuman umbilical cordHuman serumInfectious mononucleosisCarrier cell linesB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationDNA synthesisLaboratory strainsStimulation of DNAHuman lymphocytesLymphocytesBiological behaviorPrimary culturesAbortive infectionAntigen
1974
Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference
Miller G, Robinson J, Heston L, Lipman M. Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 1974, 71: 4006-4010. PMID: 4372601, PMCID: PMC434316, DOI: 10.1073/pnas.71.10.4006.Peer-Reviewed Original ResearchConceptsEB virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumEpstein-Barr virusPretreatment of lymphocytesCell linesHuman umbilical cordDNA synthesisHuman serumInfectious mononucleosisCarrier cell linesBiologic behaviorB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationNonproducer cell linesHuman lymphocytesLaboratory strainsLymphocytesBiologic activityPrimary culturesAbortive infectionExpression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures.
Miller G, Heston L. Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures. The Yale Journal Of Biology And Medicine 1974, 47: 123-35. PMID: 4372815, PMCID: PMC2596417.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr viralCapsid antigenNuclear antigenComplement fixingContinuous lymphoblastoid cell linesEpstein-Barr viral capsidViable cellsContent of antigensProportion of cellsLymphocyte transformationAnticomplement immunofluorescenceLymphoblastoid cell linesComplement-fixing (CF) antigenCell subpopulationsComplement fixationAntigenAntigen complexIntranuclear antigensProducer linesCell linesCells
1969
Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1
Miller G, Enders J, Lisco H, Kohn H. Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1. Experimental Biology And Medicine 1969, 132: 247-252. PMID: 4899209, DOI: 10.3181/00379727-132-34189.Peer-Reviewed Original ResearchConceptsCancer Research FoundationWhite blood cellsHuman placental cellsHuman blood leukocytesNormal human blood leukocytesNormal adult malesEBV antigensChildren 1Blood leukocytesPlacental cellsClinical specimensBlood cellsPossible roleEBVLeukocytesAntigenAdult malesCellsLeukocyte linesCulture system