2008
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy
1972
SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE
KUHAR M, ROTH R, AGHAJANIAN G. SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE. Journal Of Pharmacology And Experimental Therapeutics 1972, 181: 36-45. PMID: 4552069, DOI: 10.1016/s0022-3565(25)29173-x.Peer-Reviewed Original ResearchConceptsConcentrations of 5-HTRaphe lesionsSynaptosomal uptakeUptake of 3H-5-HTTricyclic agent imipramineMidbrain raphe lesionsNerve endingsMidbrain raphe nucleiTryptophan hydroxylase activityTime coursePlacement of lesionsRaphe nucleusSerotonin uptakeRaphe neuronsLesioned animalsUptake activityMidbrain areaL-norepinephrineLesionsHydroxylase activityRapheIncubation mediumForebrainL-tryptophanAnimals
1968
STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM
SHEAUD M, AGHAJANIAN G. STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM. Journal Of Pharmacology And Experimental Therapeutics 1968, 163: 425-430. PMID: 4878661, DOI: 10.1016/s0022-3565(25)28089-2.Peer-Reviewed Original Research
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